Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration

Clinical Drug Investigation

Volumn 35, Issue 10, 2015, Pages 625-632

  Atkinson, Hartley C ^a   Stanescu, Ioana ^a   Frampton, Chris ^b   Salem, Isam I ^c   Beasley, Charles P H ^a   Robson, Richard ^d  

^a AFT Pharmaceuticals Ltd Takapuna   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c International Pharmaceutical Research Center Amman   (Jordan)

^d Christchurch Clinical Studies Trust Ltd   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PARACETAMOL; DRUG COMBINATION;

ADULT; ANKLE FRACTURE; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CANNULATION SITE FOREAM BRUISING; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENTIATION; DRUG SAFETY; DYSPEPSIA; ELIMINATION RATE CONSTANT; FAINTNESS; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; LETHARGY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MONOTHERAPY; NAUSEA; NERVE INJURY; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECTUM HEMORRHAGE; SINGLE DRUG DOSE; SKIN BRUISING; SORE THROAT; SUPERFICIAL RADIAL NERVE IRRITATION; TANDEM MASS SPECTROMETRY; UPPER RESPIRATORY TRACT INFECTION; ADOLESCENT; BIOAVAILABILITY; BLOOD; CROSSOVER PROCEDURE; DRUG COMBINATION; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; THERAPEUTIC EQUIVALENCE; YOUNG ADULT;

ACETAMINOPHEN; ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CROSS-OVER STUDIES; DRUG COMBINATIONS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; IBUPROFEN; MALE; MIDDLE AGED; THERAPEUTIC EQUIVALENCY; YOUNG ADULT;

EID: 84942505142     PISSN: 11732563     EISSN: 11791918     Source Type: Journal    
DOI: 10.1007/s40261-015-0320-8     Document Type: Article

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