Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

Nature Biotechnology

Volumn 33, Issue 7, 2015, Pages 694-696

  Strop, Pavel ^a   Delaria, Kathy ^a   Foletti, Davide ^a   Witt, Jody Melton ^a   Hasa Moreno, Adela ^a   Poulsen, Kris ^a   Casas, Meritxell Galindo ^a   Dorywalska, Magdalena ^a   Farias, Santiago ^a   Pios, Ariel ^a   Lui, Victor ^a   Dushin, Russell ^a   Zhou, Dahui ^a   Navaratnam, Thayalan ^a   Tran, Thomas Toan ^a   Sutton, Janette ^a   Lindquist, Kevin C ^a   Han, Bora ^a   Liu, Shu Hui ^a   Shelton, David L ^a   Pons, Jaume ^a   Rajpal, Arvind ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY CONJUGATE; ANTIBODY DRUG CONJUGATE; BRENTUXIMAB VEDOTIN; CYSTEINE CONJUGATE; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; CANCER INHIBITION; CELL KILLING; CYTOTOXICITY; DRUG CONJUGATION; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; LETTER; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; THERAPEUTIC INDEX; ANIMAL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; DRUG SCREENING; MEDICINAL CHEMISTRY; MOUSE; RAT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOCONJUGATES; MICE; MODELS, MOLECULAR; RATS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942502479     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3274     Document Type: Letter

References (6)

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