Phloroglucinol attenuates the cognitive deficits of the 5XFAD mouse model of Alzheimer's disease

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Yang, Eun Jeong ^a   Ahn, Sangzin ^a   Ryu, Junghwa ^a   Choi, Moon Seok ^a   Choi, Shinkyu ^a   Chong, Young Hae ^b   Hyun, Jin Won ^c   Chang, Moon Jeong ^d   Kim, Hye Sun ^a,e  

^a Seoul National University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c Jeju National University School of Medicine   (South Korea)

^d Kookmin University   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; PHLOROGLUCINOL; REACTIVE OXYGEN METABOLITE; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); DLGH4 PROTEIN, MOUSE; GUANYLATE KINASE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; SYNAPTOPHYSIN;

5XFAD MOUSE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN TISSUE; CELL DENSITY; COGNITIVE DEFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENDRITIC SPINE; DRUG EFFICACY; DRUG MECHANISM; ECKLONIA CAVA; HIPPOCAMPAL NEURONAL CULTURE; HT 22 CELL LINE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; SPATIAL MEMORY; T-MAZE TEST; WORKING MEMORY; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; COGNITION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; FEMALE; HIPPOCAMPUS; HUMAN; INTRACELLULAR SPACE; MAZE TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; RAT; SYNAPSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL LINE; COGNITION; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; FEMALE; GUANYLATE KINASES; HIPPOCAMPUS; HUMANS; INTRACELLULAR SPACE; MAZE LEARNING; MEMBRANE PROTEINS; MICE; PEPTIDE FRAGMENTS; PHLOROGLUCINOL; PREGNANCY; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; RATS; REACTIVE OXYGEN SPECIES; SYNAPSES; SYNAPTOPHYSIN;

EID: 84942432466     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135686     Document Type: Article

References (52)

1. Glenner GG, Wong CW. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. 1984. Biochemical and biophysical research communications. 2012; 425(3):534-9. doi: 10.1016/j.bbrc.2012.08.020 PMID: 22925670
2. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 1985; 82(12):4245-9. PMID: 3159021
3. Goedert M, Wischik CM, Crowther RA, Walker JE, Klug A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proceedings of the National Academy of Sciences of the United States of America. 1988; 85(11):4051-5. PMID: 3131773
4. Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proceedings of the National Academy of Sciences of the United States of America. 1986; 83(13):4913-7. PMID: 3088567
5. Ihara Y, Nukina N, Miura R, Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. Journal of biochemistry. 1986; 99(6):1807-10. PMID: 2427509
6. Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 1986; 83(11):4044-8. PMID: 2424016
7. Palop JJ, Mucke L. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nature neuroscience. 2010; 13(7):812-8. doi: 10.1038/nn.2583 PMID: 20581818
8. Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nature reviews Drug discovery. 2004; 3(3):205-14. PMID: 15031734
9. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell. 1994; 77(6):817-27. PMID: 8004671
10. Ruszkiewicz J, Albrecht J. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Neurochemistry international. 2015.
11. Parajuli B, Sonobe Y, Horiuchi H, Takeuchi H, Mizuno T, Suzumura A. Oligomeric amyloid beta induces IL-1beta processing via production of ROS: implication in Alzheimer's disease. Cell death & disease. 2013; 4:e975.
12. Butterfield DA, Drake J, Pocernich C, Castegna A. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends in molecular medicine. 2001; 7(12):548-54. PMID: 11733217
13. Katsuki H, Nakanishi C, Saito H, Matsuki N. Biphasic effect of hydrogen peroxide on field potentials in rat hippocampal slices. European journal of pharmacology. 1997; 337(2-3):213-8. PMID: 9430416
14. Gabbita SP, Aksenov MY, Lovell MA, Markesbery WR. Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain. Journal of neurochemistry. 1999; 73(4):1660-6. PMID: 10501213
15. Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Ham YM, et al. Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation. Journal of cellular biochemistry. 2006; 97(3):609-20. PMID: 16215988
16. Kim HS, Lee K, Kang KA, Lee NH, Hyun JW, Kim HS. Phloroglucinol exerts protective effects against oxidative stress-induced cell damage in SH-SY5Y cells. Journal of pharmacological sciences. 2012; 119(2):186-92. PMID: 22790317
17. Kang KA, Zhang R, Chae S, Lee SJ, Kim J, Kim J, et al. Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo. Chemico-biological interactions. 2010; 185(3):215-26. doi: 10.1016/j.cbi.2010.02.031 PMID: 20188716
18. Ryu J, Zhang R, Hong BH, Yang EJ, Kang KA, Choi M, et al. Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity. PloS one. 2013; 8(8):e71178. doi: 10.1371/journal.pone.0071178 PMID: 23976995
19. Devi L, Ohno M. PERK mediates eIF2alpha phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiology of aging. 2014; 35(10):2272-81. doi: 10.1016/j.neurobiolaging.2014.04.031 PMID: 24889041
20. Zeng Y, Zhang J, Zhu Y, Zhang J, Shen H, Lu J, et al. Tripchlorolide improves cognitive deficits by reducing amyloid beta and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. Journal of neurochemistry. 2015; 133(1):38-52 doi: 10.1111/jnc.13056 PMID: 25661995
21. Dinamarca MC, Cerpa W, Garrido J, Hancke JL, Inestrosa NC. Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits. Molecular psychiatry. 2006; 11(11):1032-48. PMID: 16880827
22. Arancibia S, Silhol M, Mouliere F, Meffre J, Hollinger I, Maurice T, et al. Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiology of disease. 2008; 31(3):316-26. doi: 10.1016/j.nbd.2008.05.012 PMID: 18585459
23. Morris JK, Honea RA, Vidoni ED, Swerdlow RH, Burns JM. Is Alzheimer's disease a systemic disease? Biochimica et biophysica acta. 2014; 1842(9):1340-9. doi: 10.1016/j.bbadis.2014.04.012 PMID: 24747741
24. Gu Z, Liu W, Yan Z. {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2 +/calmodulin-dependent protein kinase II synaptic distribution. The Journal of biological chemistry. 2009; 284(16):10639-49. doi: 10.1074/jbc.M806508200 PMID: 19240035
25. Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nature reviews Neuroscience. 2008; 9(1):65-75. PMID: 18094707
26. Mucke L, Selkoe DJ. Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction. Cold Spring Harbor perspectives in medicine. 2012; 2(7):a006338. doi: 10.1101/cshperspect.a006338 PMID: 22762015
27. Segal M. Dendritic spines and long-term plasticity. Nature reviews Neuroscience. 2005; 6(4):277-84. PMID: 15803159
28. Holtmaat A, Svoboda K. Experience-dependent structural synaptic plasticity in the mammalian brain. Nature reviews Neuroscience. 2009; 10(9):647-58. doi: 10.1038/nrn2699 PMID: 19693029
29. Kamsler A, Segal M. Hydrogen peroxide modulation of synaptic plasticity. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2003; 23(1):269-76.
30. Massaad CA, Klann E. Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxidants & redox signaling. 2011; 14(10):2013-54.
31. Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Molecular and cellular neurosciences. 2006; 33(3):274-82. PMID: 16962789
32. Hongpaisan J, Sun MK, Alkon DL. PKC epsilon activation prevents synaptic loss, Abeta elevation, and cognitive deficits in Alzheimer's disease transgenic mice. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2011; 31(2):630-43.
33. LaFerla FM, Green KN, Oddo S. Intracellular amyloid-beta in Alzheimer's disease. Nature reviews Neuroscience. 2007; 8(7):499-509. PMID: 17551515
34. Ripoli C, Cocco S, Li Puma DD, Piacentini R, Mastrodonato A, Scala F, et al. Intracellular accumulation of amyloid-beta (Abeta) protein plays a major role in Abeta-induced alterations of glutamatergic synaptic transmission and plasticity. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2014; 34(38):12893-903.
35. Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, et al. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiology of disease. 2005; 20(2):187-98. PMID: 16242627
36. Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, et al. Effects of different amyloid betaprotein analogues on synaptic function. Neurobiology of aging. 2013; 34(4):1032-44. doi: 10.1016/j.neurobiolaging.2012.06.027 PMID: 23046860
37. Mattson MP. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiological reviews. 1997; 77(4):1081-132. PMID: 9354812
38. Matsuoka Y, Picciano M, La Francois J, Duff K. Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease. Neuroscience. 2001; 104(3):609-13. PMID: 11440793
39. Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, et al. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. Journal of neurochemistry. 1998; 70(5):2212-5. PMID: 9572310
40. Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. Journal of neurochemistry. 2006; 96(5):1322-35. PMID: 16478525
41. Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Human molecular genetics. 2006; 15(9):1437-49. PMID: 16551656
42. Apelt J, Bigl M, Wunderlich P, Schliebs R. Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience. 2004; 22(7):475-84.
43. De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, et al. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. The Journal of biological chemistry. 2007; 282(15):11590-601. PMID: 17308309
44. Balboa EM, Conde E, Moure A, Falque E, Dominguez H. In vitro antioxidant properties of crude extracts and compounds from brown algae. Food chemistry. 2013; 138(2-3):1764-85. doi: 10.1016/j.foodchem.2012.11.026 PMID: 23411309
45. So MJ, Cho EJ. Phloroglucinol Attenuates Free Radical-induced Oxidative Stress. Preventive nutrition and food science. 2014; 19(3):129-35. doi: 10.3746/pnf.2014.19.3.129 PMID: 25320709
46. Queguineur B, Goya L, Ramos S, Martin MA, Mateos R, Bravo L. Phloroglucinol: antioxidant properties and effects on cellular oxidative markers in human HepG2 cell line. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association. 2012; 50(8):2886-93.
47. Moon C, Kim SH, Kim JC, Hyun JW, Lee NH, Park JW, et al. Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice. Phytotherapy research: PTR. 2008; 22(2):238-42. PMID: 17886227
48. Piao MJ, Ahn MJ, Kang KA, Kim KC, Zheng J, Yao CW, et al. Phloroglucinol inhibits ultraviolet B radiation-induced oxidative stress in the mouse skin. International journal of radiation biology. 2014; 90(10):928-35. doi: 10.3109/09553002.2014.911990 PMID: 24716481
49. Du H, Guo L, Wu X, Sosunov AA, McKhann GM, Chen JX, et al. Cyclophilin D deficiency rescues Abeta-impaired PKA/CREB signaling and alleviates synaptic degeneration. Biochimica et biophysica acta. 2014; 1842(12 Pt A):2517-27. doi: 10.1016/j.bbadis.2013.03.004 PMID: 23507145
50. Yuste R. Dendritic spines and distributed circuits. Neuron. 2011; 71(5):772-81. doi: 10.1016/j.neuron.2011.07.024 PMID: 21903072
51. Small SA, Chawla MK, Buonocore M, Rapp PR, Barnes CA. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(18):7181-6. PMID: 15118105
52. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2006; 26(40):10129-40.