Molecular signals underlying hair follicle morphogenesis and cutaneous regeneration

Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies

Volumn , Issue , 2014, Pages 89-100

  Wang, Xusheng ^a   Wu, Yaojiong ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Connective tissue growth factor (CTGF); Dermal papilla (DP) cells; Edar signaling; Embryonic day (ED); Hair follicle morphogenesis; Keratinocyte growth factor (KGF) and epidermal growth factor (EGF) signals; Label retaining cells (LRCs); Mesenchymal stem cells; Platelet derived growth factor A (PDGF A); Stem and niche cells; Transforming growth factor (TGF )

Indexed keywords

EID: 84942372798     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-7726-2_10     Document Type: Chapter

References (28)

1. Abreu JG, Ketpura NI, Reversade B, De Robertis EM (2002) Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 8:599-604
2. Blanpain C, Lowry WE, Geoghegan A, Polak L, Fuchs E (2004) Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 5:635-648
3. Chen L, Tredget EE, Wu PY, Wu Y (2008) Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 4:e1886
4. Gat U, DasGupta R, Degenstein L, Fuchs E (1998) De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 5:605-614
5. Gregory CA, Singh H, Perry AS, Prockop DJ (2003) The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J Biol Chem 30:28067-28078
6. Hardy MH (1992) The secret life of the hair follicle. Trends Genet 2:55-61
7. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E (2008) NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2:299-310
8. Hwang J, Mehrani T, Millar SE, Morasso MI (2008) Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development 18:3149-3159
9. Ito M, Liu Y, Yang Z, Nguyen J, Liang F, Morris RJ, Cotsarelis G (2005) Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med 12:1351-1354
10. Ito M, Yang Z, Andl T, Cui C, Kim N, Millar SE, Cotsarelis G (2007) Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 7142:316-320
11. Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgard R (2008) Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet 11:1291-1299
12. Kishimoto J, Burgeson RE, Morgan BA (2000) Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev 10:1181-1185
13. Levy V, Lindon C, Zheng Y, Harfe BD, Morgan BA (2007) Epidermal stem cells arise from the hair follicle after wounding. FASEB J 7:1358-1366
14. Li L, Clevers H (2010) Coexistence of quiescent and active adult stem cells in mammals. Science 5965:542-545
15. Martin P (1997) Wound healing-aiming for perfect skin regeneration. Science 5309:75-81
16. Mikkola ML, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, Thesleff I (1999) Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev 2:133-146
17. Mohri Y, Kato S, Umezawa A, Okuyama R, Nishimori K (2008) Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4. Dev Dyn 8:2235-2242
18. Narhi K, Jarvinen E, Birchmeier W, Taketo MM, Mikkola ML, Thesleff I (2008) Sustained epithelial betacatenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development 6:1019-1028
19. Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM (2011) Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science 6029:586-589
20. Qiao J, Philips E, Teumer J (2008) A graft model for hair development. Exp Dermatol 6:512-518
21. Reynolds AJ, Jahoda CA (1992) Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis. Development 2:587-593
22. Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA (2009a) KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development 13:2153-2164
23. Richardson GD, Fantauzzo KA, Bazzi H, Maatta A, Jahoda CA (2009b) Dynamic expression of Syndecan-1 during hair follicle morphogenesis. Gene Expr Patterns 6:454-460
24. Schmidt-Ullrich R, Paus R (2005) Molecular principles of hair follicle induction and morphogenesis. Bioessays 3:247-261
25. Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgard R, Clevers H (2010) Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 5971:1385-1389
26. Wang X, Tredget EE, Wu Y (2012) Dynamic signals for hair follicle development and regeneration. Stem Cells Dev 1:7-18
27. Wu Y, Zhao RC, Tredget EE (2010) Concise review:bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells 5:905-915
28. Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R (2009) Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/betacatenin signaling pathways in hair follicle induction. Dev Cell 1:49-61