Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years—a retrospective cohort study

Clinical Rheumatology

Volumn 34, Issue 10, 2015, Pages 1721-1728

  Luo, Yan ^a,b   Zhang, Lili ^a   Fei, Yunyun ^a   Li, Yiqun ^a   Hao, Donglin ^a   Liu, Yi ^b   Zhao, Yan ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Anti SSA Ro antibodies; Connective tissue disease (CTD); Neonatal lupus erythematosus; Pregnancy; SLE

Indexed keywords

HYDROXYCHLOROQUINE; LA ANTIBODY; RO ANTIBODY; STEROID; ANTINUCLEAR ANTIBODY; RIBONUCLEOPROTEIN; SS-A ANTIGEN;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; COHORT ANALYSIS; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; FOLLOW UP; GESTATIONAL AGE; HUMAN; INCIDENCE; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MIXED CONNECTIVE TISSUE DISEASE; NEONATAL LUPUS ERYTHEMATOSUS; NEWBORN; NEWBORN DISEASE; PREGNANCY OUTCOME; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SECOND TRIMESTER PREGNANCY; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; THIRD TRIMESTER PREGNANCY; BLOOD; COMPLICATION; INFANT; LUPUS ERYTHEMATOSUS, SYSTEMIC; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATION; SPONTANEOUS ABORTION; YOUNG ADULT;

ABORTION, SPONTANEOUS; ADULT; ANTIBODIES, ANTINUCLEAR; ANTIPHOSPHOLIPID SYNDROME; CONNECTIVE TISSUE DISEASES; FEMALE; HUMANS; HYDROXYCHLOROQUINE; INFANT; INFANT, NEWBORN; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES; RIBONUCLEOPROTEINS; RISK FACTORS; STEROIDS; YOUNG ADULT;

EID: 84942372478     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-015-3050-7     Document Type: Article

References (24)

1. Brucato A, Doria A, Frassi M et al (2002) Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study. Lupus 11(11):716–21
2. Brucato A, Cimaz R, Caporali R et al (2011) Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. Clin Rev Allergy Immunol 40(1):27–41
3. Sonesson SE, Salomonsson S, Jacobsson LA et al (2004) Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies. Arthritis Rheum 50(4):1253–61
4. Costedoat-Chalumeau N, Amoura Z, Lupoglazoff JM et al (2004) Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group. Arthritis Rheum 50(10):3187–94
5. Llanos C, Izmirly PM, Katholi M et al (2009) Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors. Arthritis Rheum 60(10):3091–7
6. Costedoat-Chalumeau N, Amoura Z, Duhaut P et al (2003) Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group. Arthritis Rheum 48(11):3207–11
7. Izmirly PM, Kim MY, Llanos C et al (2010) Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquine. Ann Rheum Dis 69(10):1827–30
8. Izmirly PM, Costedoat-Chalumeau N, Pisoni CN et al (2012) Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus. Circulation 126(1):76–82
9. Tan EM, Cohen AS, Fries JF et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25(11):1271–7
10. Vitali C, Bombardieri S, Jonsson R et al (2002) Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 61(6):554–8
11. Sharp GC (1987) Diagnostic criteria for classification of MCTD. Mixed connective tissue diseases and antinuclear antibodies. Elsevier, Amsterdam, pp 23–32
12. Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306
13. Buyon JP, Kalunian KC, Ramsey-Goldman R et al (1999) Assessing disease activity in SLE patients during pregnancy. Lupus 8(8):677–84
14. Clowse ME (2007) Lupus activity in pregnancy. Rheum Dis Clin North Am 33(2):237–52
15. Saavedra MA, Cruz-Reyes C, Vera-Lastra O et al (2012) Impact of previous lupus nephritis on maternal and fetal outcomes during pregnancy. Clin Rheumatol 31(5):813–9
16. Levy RA, Vilela VS, Cataldo MJ et al (2001) Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and placebo-controlled study. Lupus 10(6):401–4
17. Clowse ME, Magder L, Witter F, Petri M (2006) Hydroxychloroquine in lupus pregnancy. Arthritis Rheum 54(11):3640–7
18. Lee SJ, Silverman E, Bargman JM (2011) The role of antimalarial agents in the treatment of SLE and lupus nephritis. Nat Rev Nephrol 7(12):718–29
19. De Carolis S, Botta A, Santucci S et al (2012) Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome. Lupus 21(7):776–8
20. Cortes-Hernandez J, Ordi-Ros J, Paredes F et al (2002) Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus: a prospective study of 103 pregnancies. Rheumatology 41(6):643–50
21. Liu J, Zhao Y, Song Y, Zhang W, Bian X, Yang J et al (2012) Pregnancy in women with systemic lupus erythematosus: a retrospective study of 111 pregnancies in Chinese women. J Matern Fetal Neonatal Med 25(3):261–6
22. Jaeggi E, Laskin C, Hamilton R et al (2010) The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol 55(24):2778–84
23. Tunks RD, Clowse ME, Miller SG et al (2013) Maternal autoantibody levels in congenital heart block and potential prophylaxis with antiinflammatory agents. Am J Obstet Gynecol 208(1):64 e1–7
24. Ambrosi A, Salomonsson S, Eliasson H et al (2012) Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern. Ann Rheum Dis 71(3):334–40