T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice

Gastroenterology

Volumn 149, Issue 4, 2015, Pages 1042-1052

  Dargel, Christina ^a   Bassani Sternberg, Michal ^b   Hasreiter, Julia ^a   Zani, Fabio ^c   Bockmann, Jan Hendrik ^a,d   Thiele, Frank ^a,d   Bohne, Felix ^a   Wisskirchen, Karin ^a   Wilde, Susanne ^c   Sprinzl, Martin F ^e   Schendel, Dolores J ^a,c   Krackhardt, Angela M ^a,f   Uckert, Wolfgang ^g   Wohlleber, Dirk ^f   Schiemann, Matthias ^a   Stemmer, Kerstin ^c   Heikenwälder, Mathias ^a   Busch, Dirk H ^a,d   Richter, Günther ^f   Mann, Matthias ^b   Protzer, Ulrike ^a,d   more..

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d German Center for Infection Research   (Germany)

^e UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Cancer Immunotherapy; Immune Response; Liver Cancer; Tumor Associated Antigens

Indexed keywords

GAMMA INTERFERON; GLYPICAN 3; HLA A2 ANTIGEN; POLYMER; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; EPITOPE; GLYPICAN; GPC3 PROTEIN, HUMAN; IFNG PROTEIN, HUMAN;

ADOPTIVE TRANSFER; ALLOGENEIC RESTRICTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; BIOINFORMATICS; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CD8+ T LYMPHOCYTE; CELL ENGINEERING; CELL EXPANSION; CELL KILLING; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DONOR; EMBRYO; FEMALE; GENE EXPRESSION; GENOME ANALYSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; LYMPHOCYTE CLONE; LYMPHOCYTE TRANSFER; MASS SPECTROMETRY; MOLECULAR CLONING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE; TUMOR XENOGRAFT; ADOPTIVE IMMUNOTHERAPY; ANIMAL; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; COCULTURE; CYTOTOXICITY; DRUG SCREENING; GENETIC ENGINEERING; GENETIC TRANSFECTION; GENETICS; HEPG2 CELL LINE; IMMUNOLOGY; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PROCEDURES; SCID MOUSE; TIME; TRANSPLANTATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; GENES, T-CELL RECEPTOR; GENETIC ENGINEERING; GLYPICANS; HEP G2 CELLS; HLA-A2 ANTIGEN; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LIVER NEOPLASMS; LYMPHOCYTE ACTIVATION; MICE, SCID; TIME FACTORS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942370351     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.05.055     Document Type: Article

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