메뉴 건너뛰기




Volumn 48, Issue 2, 2015, Pages 394-404

A four-season molecule: osteocalcin. Updates in its physiological roles

Author keywords

Bone turnover; Ectopic calcification; Energy metabolism; Fertility; Muscle strength; Glutamyl transferases

Indexed keywords

ALENDRONIC ACID; CYCLIN D1; CYCLIN D2; CYCLIN DEPENDENT KINASE 4; ETIDRONIC ACID; GAMMA GLUTAMYLTRANSFERASE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MENADIONE; MENAQUINONE; OSTEOCALCIN; PARATHYROID HORMONE; PHYTOMENADIONE; RALOXIFENE; SEX HORMONE; TESTOSTERONE; VITAMIN K GROUP;

EID: 84942303210     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0401-0     Document Type: Review
Times cited : (78)

References (132)
  • 1
    • 0024370924 scopus 로고
    • Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone
    • COI: 1:CAS:528:DyaL1MXlslWntL0%3D, PID: 2664828
    • P.V. Hauschka, J.B. Lian, D.E. Cole, C.M. Gundberg, Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol. Rev. 69(3), 990–1047 (1989)
    • (1989) Physiol. Rev. , vol.69 , Issue.3 , pp. 990-1047
    • Hauschka, P.V.1    Lian, J.B.2    Cole, D.E.3    Gundberg, C.M.4
  • 2
    • 0021268975 scopus 로고
    • Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis
    • COI: 1:STN:280:DyaL2c3hvVWhsA%3D%3D, PID: 6144827
    • J.P. Brown, P.D. Delmas, L. Malaval, C. Edouard, M.C. Chapuy, P.J. Meunier, Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1(8386), 1091–1093 (1984)
    • (1984) Lancet , vol.1 , Issue.8386 , pp. 1091-1093
    • Brown, J.P.1    Delmas, P.D.2    Malaval, L.3    Edouard, C.4    Chapuy, M.C.5    Meunier, P.J.6
  • 3
    • 84867749377 scopus 로고    scopus 로고
    • Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling
    • COI: 1:CAS:528:DC%2BC38Xptl2msbs%3D, PID: 22628324
    • G. Lombardi, P. Lanteri, A. Colombini, G. Banfi, Blood biochemical markers of bone turnover: pre-analytical and technical aspects of sample collection and handling. Clin. Chem. Lab. Med. 50(5), 771–789 (2012)
    • (2012) Clin. Chem. Lab. Med. , vol.50 , Issue.5 , pp. 771-789
    • Lombardi, G.1    Lanteri, P.2    Colombini, A.3    Banfi, G.4
  • 4
    • 0028097583 scopus 로고
    • Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells
    • COI: 1:CAS:528:DyaK2cXmslOms7o%3D, PID: 7962073
    • C. Chenu, S. Colucci, M. Grano, P. Zigrino, R. Barattolo, G. Zambonin, N. Baldini, P. Vergnaud, P.D. Delmas, A.Z. Zallone, Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. J. Cell Biol. 127(4), 1149–1158 (1994)
    • (1994) J. Cell Biol. , vol.127 , Issue.4 , pp. 1149-1158
    • Chenu, C.1    Colucci, S.2    Grano, M.3    Zigrino, P.4    Barattolo, R.5    Zambonin, G.6    Baldini, N.7    Vergnaud, P.8    Delmas, P.D.9    Zallone, A.Z.10
  • 5
    • 0032837888 scopus 로고    scopus 로고
    • Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor
    • COI: 1:CAS:528:DyaK1MXmvVKjurs%3D, PID: 10574573
    • P.V. Bodine, B.S. Komm, Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor. Bone 25(5), 535–543 (1999)
    • (1999) Bone , vol.25 , Issue.5 , pp. 535-543
    • Bodine, P.V.1    Komm, B.S.2
  • 6
    • 0029799613 scopus 로고    scopus 로고
    • Molecular basis and clinical application of biological markers of bone turnover
    • COI: 1:CAS:528:DyaK28Xltl2mt74%3D, PID: 8854049
    • M.S. Calvo, D.R. Eyre, C.M. Gundberg, Molecular basis and clinical application of biological markers of bone turnover. Endocr. Rev. 17(4), 333–368 (1996)
    • (1996) Endocr. Rev. , vol.17 , Issue.4 , pp. 333-368
    • Calvo, M.S.1    Eyre, D.R.2    Gundberg, C.M.3
  • 7
    • 77957986674 scopus 로고    scopus 로고
    • Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy
    • PID: 21155624
    • P.M. Kidd, Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Altern. Med. Rev. 15(3), 199–222 (2010)
    • (2010) Altern. Med. Rev. , vol.15 , Issue.3 , pp. 199-222
    • Kidd, P.M.1
  • 8
    • 0036363162 scopus 로고    scopus 로고
    • Blood coagulation
    • COI: 1:CAS:528:DC%2BD38XhsVSks78%3D
    • S. Butenas, K.G. Mann, Blood coagulation. Biochemistry (Mosc) 67(1), 3–12 (2002)
    • (2002) Biochemistry (Mosc) , vol.67 , Issue.1 , pp. 3-12
    • Butenas, S.1    Mann, K.G.2
  • 10
    • 0024519974 scopus 로고
    • Chromosomal localization of the human osteocalcin gene
    • COI: 1:CAS:528:DyaL1MXitVOisrs%3D, PID: 2785029
    • E. Puchacz, J.B. Lian, G.S. Stein, J. Wozney, K. Huebner, C. Croce, Chromosomal localization of the human osteocalcin gene. Endocrinology 124(5), 2648–2650 (1989)
    • (1989) Endocrinology , vol.124 , Issue.5 , pp. 2648-2650
    • Puchacz, E.1    Lian, J.B.2    Stein, G.S.3    Wozney, J.4    Huebner, K.5    Croce, C.6
  • 11
    • 0025029949 scopus 로고
    • Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene
    • COI: 1:CAS:528:DyaK3MXhsFCg, PID: 2394711
    • L. Cancela, C.L. Hsieh, U. Francke, P.A. Price, Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J. Biol. Chem. 265(25), 15040–15048 (1990)
    • (1990) J. Biol. Chem. , vol.265 , Issue.25 , pp. 15040-15048
    • Cancela, L.1    Hsieh, C.L.2    Francke, U.3    Price, P.A.4
  • 13
    • 0019987589 scopus 로고
    • Primary structure of monkey osteocalcin
    • COI: 1:CAS:528:DyaL38XmsVCjsw%3D%3D, PID: 6978733
    • P.V. Hauschka, S.A. Carr, K. Biemann, Primary structure of monkey osteocalcin. Biochemistry 21(4), 638–642 (1982)
    • (1982) Biochemistry , vol.21 , Issue.4 , pp. 638-642
    • Hauschka, P.V.1    Carr, S.A.2    Biemann, K.3
  • 14
    • 0242499504 scopus 로고    scopus 로고
    • Bone recognition mechanism of porcine osteocalcin from crystal structure
    • COI: 1:CAS:528:DC%2BD3sXosVOhtL4%3D, PID: 14586470
    • Q.Q. Hoang, F. Sicheri, A.J. Howard, D.S. Yang, Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425(6961), 977–980 (2003)
    • (2003) Nature , vol.425 , Issue.6961 , pp. 977-980
    • Hoang, Q.Q.1    Sicheri, F.2    Howard, A.J.3    Yang, D.S.4
  • 15
    • 0026592394 scopus 로고
    • The osteocalcin propeptide is not secreted in vivo or in vitro
    • COI: 1:CAS:528:DyaK38XhsVyrtL0%3D, PID: 1549960
    • C.M. Gundberg, M.E. Clough, The osteocalcin propeptide is not secreted in vivo or in vitro. J. Bone Miner. Res. 7(1), 73–80 (1992)
    • (1992) J. Bone Miner. Res. , vol.7 , Issue.1 , pp. 73-80
    • Gundberg, C.M.1    Clough, M.E.2
  • 16
    • 0030624665 scopus 로고    scopus 로고
    • Strategies for developing human osteocalcin standards: a critical evaluation
    • COI: 1:STN:280:DyaK2s3nt1Oluw%3D%3D, PID: 9127475
    • R. Houben, B.A. Soute, M.H. Knapen, C. Vermeer, Strategies for developing human osteocalcin standards: a critical evaluation. Scand. J. Clin. Lab. Invest. Suppl. 227, 100–104 (1997)
    • (1997) Scand. J. Clin. Lab. Invest. Suppl. , vol.227 , pp. 100-104
    • Houben, R.1    Soute, B.A.2    Knapen, M.H.3    Vermeer, C.4
  • 17
    • 40949143530 scopus 로고    scopus 로고
    • Vitamin K-dependent carboxylation
    • COI: 1:CAS:528:DC%2BD1cXltVKnu7g%3D, PID: 18374193
    • K.L. Berkner, Vitamin K-dependent carboxylation. Vitam. Horm. 78, 131–156 (2008)
    • (2008) Vitam. Horm. , vol.78 , pp. 131-156
    • Berkner, K.L.1
  • 19
    • 0022545262 scopus 로고
    • 2+-binding protein of bone matrix
    • COI: 1:CAS:528:DyaL28XlvVyjtL8%3D, PID: 3530901
    • 2+-binding protein of bone matrix. Haemostasis 16(3–4), 258–272 (1986)
    • (1986) Haemostasis , vol.16 , Issue.3-4 , pp. 258-272
    • Hauschka, P.V.1
  • 20
    • 0019978329 scopus 로고
    • Calcium-dependent alpha-helical structure in osteocalcin
    • COI: 1:CAS:528:DyaL38XhvFGgt70%3D, PID: 6807342
    • P.V. Hauschka, S.A. Carr, Calcium-dependent alpha-helical structure in osteocalcin. Biochemistry 21(10), 2538–2547 (1982)
    • (1982) Biochemistry , vol.21 , Issue.10 , pp. 2538-2547
    • Hauschka, P.V.1    Carr, S.A.2
  • 21
    • 0031967116 scopus 로고    scopus 로고
    • Dietary intake and adequacy of vitamin K
    • COI: 1:CAS:528:DyaK1cXjtFegsrw%3D, PID: 9566982
    • S.L. Booth, J.W. Suttie, Dietary intake and adequacy of vitamin K. J. Nutr. 128(5), 785–788 (1998)
    • (1998) J. Nutr. , vol.128 , Issue.5 , pp. 785-788
    • Booth, S.L.1    Suttie, J.W.2
  • 22
    • 84866283031 scopus 로고    scopus 로고
    • Vitamin K nutrition, metabolism, and requirements: current concepts and future research
    • COI: 1:CAS:528:DC%2BC38XmtVGrsb4%3D, PID: 22516726
    • M.J. Shearer, X. Fu, S.L. Booth, Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv. Nutr. 3(2), 182–195 (2012)
    • (2012) Adv. Nutr. , vol.3 , Issue.2 , pp. 182-195
    • Shearer, M.J.1    Fu, X.2    Booth, S.L.3
  • 23
    • 67749093218 scopus 로고    scopus 로고
    • Roles for vitamin K beyond coagulation
    • COI: 1:CAS:528:DC%2BD1MXht1akt7bM, PID: 19400704
    • S.L. Booth, Roles for vitamin K beyond coagulation. Annu. Rev. Nutr. 29, 89–110 (2009)
    • (2009) Annu. Rev. Nutr. , vol.29 , pp. 89-110
    • Booth, S.L.1
  • 24
    • 0024598306 scopus 로고
    • Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells
    • COI: 1:CAS:528:DyaL1MXhvFWmurw%3D, PID: 2495300
    • A. Barchowsky, K. Tabrizi, R.S. Kent, A.R. Whorton, Inhibition of prostaglandin synthesis after metabolism of menadione by cultured porcine endothelial cells. J. Clin. Invest. 83(4), 1153–1159 (1989)
    • (1989) J. Clin. Invest. , vol.83 , Issue.4 , pp. 1153-1159
    • Barchowsky, A.1    Tabrizi, K.2    Kent, R.S.3    Whorton, A.R.4
  • 25
    • 20544447191 scopus 로고    scopus 로고
    • Osteoporosis: the role of micronutrients
    • COI: 1:CAS:528:DC%2BD2MXktlyks7k%3D, PID: 15883457
    • J.W. Nieves, Osteoporosis: the role of micronutrients. Am. J. Clin. Nutr. 81(5), 1232S–1239S (2005)
    • (2005) Am. J. Clin. Nutr. , vol.81 , Issue.5 , pp. 1232-1239
    • Nieves, J.W.1
  • 27
    • 36048965821 scopus 로고    scopus 로고
    • Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene
    • COI: 1:CAS:528:DC%2BD2sXhtlWmsrjO, PID: 17875939
    • M. Igarashi, Y. Yogiashi, M. Mihara, I. Takada, H. Kitagawa, S. Kato, Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. Mol. Cell. Biol. 27(22), 7947–7954 (2007)
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.22 , pp. 7947-7954
    • Igarashi, M.1    Yogiashi, Y.2    Mihara, M.3    Takada, I.4    Kitagawa, H.5    Kato, S.6
  • 29
    • 33744495081 scopus 로고    scopus 로고
    • The mechanisms of vitamin K2-induced apoptosis of myeloma cells
    • COI: 1:CAS:528:DC%2BD28Xls1Srt7o%3D, PID: 16670066
    • T. Tsujioka, Y. Miura, T. Otsuki, Y. Nishimura, F. Hyodoh, H. Wada, T. Sugihara, The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 91(5), 613–619 (2006)
    • (2006) Haematologica , vol.91 , Issue.5 , pp. 613-619
    • Tsujioka, T.1    Miura, Y.2    Otsuki, T.3    Nishimura, Y.4    Hyodoh, F.5    Wada, H.6    Sugihara, T.7
  • 30
    • 77951951340 scopus 로고    scopus 로고
    • Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
    • COI: 1:CAS:528:DC%2BC3cXlsVWrtbc%3D, PID: 20335553
    • K. Nimptsch, S. Rohrmann, R. Kaaks, J. Linseisen, Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am. J. Clin. Nutr. 91(5), 1348–1358 (2010)
    • (2010) Am. J. Clin. Nutr. , vol.91 , Issue.5 , pp. 1348-1358
    • Nimptsch, K.1    Rohrmann, S.2    Kaaks, R.3    Linseisen, J.4
  • 32
    • 33745377108 scopus 로고    scopus 로고
    • Pleiotropic actions of vitamin K: protector of bone health and beyond?
    • COI: 1:CAS:528:DC%2BD28Xms1Gktrw%3D, PID: 16815498
    • M. Kaneki, T. Hosoi, Y. Ouchi, H. Orimo, Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition 22(7–8), 845–852 (2006)
    • (2006) Nutrition , vol.22 , Issue.7-8 , pp. 845-852
    • Kaneki, M.1    Hosoi, T.2    Ouchi, Y.3    Orimo, H.4
  • 33
    • 84866294287 scopus 로고    scopus 로고
    • Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase
    • COI: 1:CAS:528:DC%2BC38XmtVGrs7o%3D, PID: 22516721
    • M.A. Rishavy, K.L. Berkner, Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv. Nutr. 3(2), 135–148 (2012)
    • (2012) Adv. Nutr. , vol.3 , Issue.2 , pp. 135-148
    • Rishavy, M.A.1    Berkner, K.L.2
  • 34
    • 0000376008 scopus 로고
    • Vitamin K dependent modifications of glutamic acid residues in prothrombin
    • COI: 1:CAS:528:DyaE2cXlsVOlsbY%3D, PID: 4528109
    • J. Stenflo, P. Fernlund, W. Egan, P. Roepstorff, Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc. Natl. Acad. Sci. USA 71(7), 2730–2733 (1974)
    • (1974) Proc. Natl. Acad. Sci. USA , vol.71 , Issue.7 , pp. 2730-2733
    • Stenflo, J.1    Fernlund, P.2    Egan, W.3    Roepstorff, P.4
  • 35
    • 0005811867 scopus 로고
    • Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue
    • COI: 1:CAS:528:DyaE28XislGruw%3D%3D, PID: 1060074
    • P.V. Hauschka, J.B. Lian, P.M. Gallop, Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc. Natl. Acad. Sci. USA 72(10), 3925–3929 (1975)
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , Issue.10 , pp. 3925-3929
    • Hauschka, P.V.1    Lian, J.B.2    Gallop, P.M.3
  • 36
    • 0001516132 scopus 로고
    • Characterization of a gamma-carboxyglutamic acid-containing protein from bone
    • COI: 1:CAS:528:DyaE28XktFGrsrk%3D, PID: 1064018
    • P.A. Price, A.A. Otsuka, J.W. Poser, J. Kristaponis, N. Raman, Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc. Natl. Acad. Sci. USA 73(5), 1447–1451 (1976)
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , Issue.5 , pp. 1447-1451
    • Price, P.A.1    Otsuka, A.A.2    Poser, J.W.3    Kristaponis, J.4    Raman, N.5
  • 37
    • 84871065191 scopus 로고    scopus 로고
    • The role of osteocalcin in human glucose metabolism: marker or mediator?
    • COI: 1:CAS:528:DC%2BC38XhvVChsLjM, PID: 23147574
    • S.L. Booth, A. Centi, S.R. Smith, C. Gundberg, The role of osteocalcin in human glucose metabolism: marker or mediator? Nat. Rev. Endocrinol. 9(1), 43–55 (2013)
    • (2013) Nat. Rev. Endocrinol. , vol.9 , Issue.1 , pp. 43-55
    • Booth, S.L.1    Centi, A.2    Smith, S.R.3    Gundberg, C.4
  • 38
    • 70349787472 scopus 로고    scopus 로고
    • Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
    • COI: 1:CAS:528:DC%2BD1MXhtFyru7vF, PID: 19692494
    • J.C. McCann, B.N. Ames, Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am. J. Clin. Nutr. 90(4), 889–907 (2009)
    • (2009) Am. J. Clin. Nutr. , vol.90 , Issue.4 , pp. 889-907
    • McCann, J.C.1    Ames, B.N.2
  • 39
    • 80054070913 scopus 로고    scopus 로고
    • Bleeding, vertebral fractures and vascular calcifications in patients treated with warfarin: hope for lower risks with alternative therapies
    • COI: 1:CAS:528:DC%2BC3MXhsVSit7zJ, PID: 21623708
    • M. Fusaro, G. Crepaldi, S. Maggi, A. D’Angelo, L. Calo, D. Miozzo, A. Fornasieri, M. Gallieni, Bleeding, vertebral fractures and vascular calcifications in patients treated with warfarin: hope for lower risks with alternative therapies. Curr. Vasc. Pharmacol. 9(6), 763–769 (2011)
    • (2011) Curr. Vasc. Pharmacol. , vol.9 , Issue.6 , pp. 763-769
    • Fusaro, M.1    Crepaldi, G.2    Maggi, S.3    D’Angelo, A.4    Calo, L.5    Miozzo, D.6    Fornasieri, A.7    Gallieni, M.8
  • 40
    • 0024820519 scopus 로고
    • Gla-containing proteins of bone
    • COI: 1:STN:280:DyaK3c7gslCntQ%3D%3D, PID: 2691199
    • P.A. Price, Gla-containing proteins of bone. Connect. Tissue Res. 21(1–4), 51–57 (1989)
    • (1989) Connect. Tissue Res. , vol.21 , Issue.1-4 , pp. 51-57
    • Price, P.A.1
  • 41
    • 0024372773 scopus 로고
    • Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone
    • COI: 1:CAS:528:DyaL1MXkvFChsbY%3D, PID: 2549810
    • P.V. Hauschka, F.H. Wians Jr, Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone. Anat. Rec. 224(2), 180–188 (1989)
    • (1989) Anat. Rec. , vol.224 , Issue.2 , pp. 180-188
    • Hauschka, P.V.1    Wians, F.H.2
  • 43
    • 0031665086 scopus 로고    scopus 로고
    • Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin
    • COI: 1:CAS:528:DyaK1cXlvF2hur4%3D, PID: 9737340
    • A.L. Boskey, S. Gadaleta, C. Gundberg, S.B. Doty, P. Ducy, G. Karsenty, Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin. Bone 23(3), 187–196 (1998)
    • (1998) Bone , vol.23 , Issue.3 , pp. 187-196
    • Boskey, A.L.1    Gadaleta, S.2    Gundberg, C.3    Doty, S.B.4    Ducy, P.5    Karsenty, G.6
  • 44
    • 84871057737 scopus 로고    scopus 로고
    • Non-collageneous proteins influence bone mineral size, shape and orientation: a SAXS study
    • A. Poundarik, C. Gundberg, D. Vashishth, Non-collageneous proteins influence bone mineral size, shape and orientation: a SAXS study. J. Bone. Miner. Res. 26(S1), S1 (2011)
    • (2011) J. Bone. Miner. Res. , vol.26 , Issue.1 , pp. 1
    • Poundarik, A.1    Gundberg, C.2    Vashishth, D.3
  • 45
    • 0030033534 scopus 로고    scopus 로고
    • Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering
    • COI: 1:CAS:528:DyaK28Xht1Omu7w%3D, PID: 8567960
    • P. Fratzl, O. Paris, K. Klaushofer, W.J. Landis, Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering. J. Clin. Invest. 97(2), 396–402 (1996)
    • (1996) J. Clin. Invest. , vol.97 , Issue.2 , pp. 396-402
    • Fratzl, P.1    Paris, O.2    Klaushofer, K.3    Landis, W.J.4
  • 46
    • 2942631661 scopus 로고    scopus 로고
    • Extracellular matrix mineralization is regulated locally; different roles of two Gla-containing proteins
    • COI: 1:CAS:528:DC%2BD2cXkslyqsL0%3D, PID: 15184399
    • M. Murshed, T. Schinke, M.D. McKee, G. Karsenty, Extracellular matrix mineralization is regulated locally; different roles of two Gla-containing proteins. J. Cell Biol. 165(5), 625–630 (2004)
    • (2004) J. Cell Biol. , vol.165 , Issue.5 , pp. 625-630
    • Murshed, M.1    Schinke, T.2    McKee, M.D.3    Karsenty, G.4
  • 47
    • 0023226326 scopus 로고
    • Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants
    • COI: 1:CAS:528:DyaL2sXlvFGmsrc%3D, PID: 3304665
    • J. Glowacki, J.B. Lian, Impaired recruitment and differentiation of osteoclast progenitors by osteocalcin-deplete bone implants. Cell. Differ. 21(4), 247–254 (1987)
    • (1987) Cell. Differ. , vol.21 , Issue.4 , pp. 247-254
    • Glowacki, J.1    Lian, J.B.2
  • 48
    • 84855987634 scopus 로고    scopus 로고
    • The contribution of bone to whole-organism physiology
    • COI: 1:CAS:528:DC%2BC38Xps1Crsw%3D%3D, PID: 22258610
    • G. Karsenty, M. Ferron, The contribution of bone to whole-organism physiology. Nature 481(7381), 314–320 (2012)
    • (2012) Nature , vol.481 , Issue.7381 , pp. 314-320
    • Karsenty, G.1    Ferron, M.2
  • 49
    • 79958753138 scopus 로고    scopus 로고
    • Bone: from a reservoir of minerals to a regulator of energy metabolism
    • COI: 1:CAS:528:DC%2BC3MXktVGjtbc%3D, PID: 21346725
    • C.B. Confavreux, Bone: from a reservoir of minerals to a regulator of energy metabolism. Kidney Int. Suppl. 121, S14–S19 (2011)
    • (2011) Kidney Int. Suppl. , vol.121 , pp. 14-19
    • Confavreux, C.B.1
  • 50
    • 0019831082 scopus 로고
    • Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat
    • COI: 1:CAS:528:DyaL3MXitVKhsLk%3D, PID: 6971290
    • P.A. Price, J.W. Lothringer, S.A. Baukol, A.H. Reddi, Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat. J. Biol. Chem. 256(8), 3781–3784 (1981)
    • (1981) J. Biol. Chem. , vol.256 , Issue.8 , pp. 3781-3784
    • Price, P.A.1    Lothringer, J.W.2    Baukol, S.A.3    Reddi, A.H.4
  • 51
    • 0034526233 scopus 로고    scopus 로고
    • Molecular markers of bone turnover: biochemical, technical and analytical aspects
    • PID: 11193236
    • M.J. Seibel, Molecular markers of bone turnover: biochemical, technical and analytical aspects. Osteoporos. Int. 11(Suppl. 6), S18–S29 (2000)
    • (2000) Osteoporos. Int. , vol.11 , pp. 18-29
    • Seibel, M.J.1
  • 52
    • 0031917773 scopus 로고    scopus 로고
    • Diurnal variation in total and undercarboxylated osteocalcin: influence of increased dietary phylloquinone
    • COI: 1:CAS:528:DyaK1cXislSrsbw%3D, PID: 9541523
    • L.J. Sokoll, S.L. Booth, K.W. Davidson, G.E. Dallal, J.A. Sadowski, Diurnal variation in total and undercarboxylated osteocalcin: influence of increased dietary phylloquinone. Calcif. Tissue Int. 62(5), 447–452 (1998)
    • (1998) Calcif. Tissue Int. , vol.62 , Issue.5 , pp. 447-452
    • Sokoll, L.J.1    Booth, S.L.2    Davidson, K.W.3    Dallal, G.E.4    Sadowski, J.A.5
  • 53
    • 0027484982 scopus 로고
    • Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture
    • COI: 1:STN:280:DyaK2c%2FnvVyhtw%3D%3D, PID: 8256661
    • S.J. Hodges, K. Akesson, P. Vergnaud, K. Obrant, P.D. Delmas, Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J. Bone Miner. Res. 8(10), 1241–1245 (1993)
    • (1993) J. Bone Miner. Res. , vol.8 , Issue.10 , pp. 1241-1245
    • Hodges, S.J.1    Akesson, K.2    Vergnaud, P.3    Obrant, K.4    Delmas, P.D.5
  • 54
    • 0026409481 scopus 로고
    • Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck
    • COI: 1:STN:280:DyaK387otFOgsg%3D%3D, PID: 1797053
    • S.J. Hodges, M.J. Pilkington, T.C. Stamp, A. Catterall, M.J. Shearer, L. Bitensky, J. Chayen, Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12(6), 387–389 (1991)
    • (1991) Bone , vol.12 , Issue.6 , pp. 387-389
    • Hodges, S.J.1    Pilkington, M.J.2    Stamp, T.C.3    Catterall, A.4    Shearer, M.J.5    Bitensky, L.6    Chayen, J.7
  • 59
    • 33947520767 scopus 로고    scopus 로고
    • Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls
    • PID: 17349078
    • E. O’Connor, C. Molgaard, K.F. Michaelsen, J. Jakobsen, C.J. Lamberg-Allardt, K.D. Cashman, Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br. J. Nutr. 97(4), 661–666 (2007)
    • (2007) Br. J. Nutr. , vol.97 , Issue.4 , pp. 661-666
    • O’Connor, E.1    Molgaard, C.2    Michaelsen, K.F.3    Jakobsen, J.4    Lamberg-Allardt, C.J.5    Cashman, K.D.6
  • 60
    • 0027232105 scopus 로고
    • Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women
    • COI: 1:CAS:528:DyaK3sXktVKnsbw%3D, PID: 8473517
    • P. Szulc, M.C. Chapuy, P.J. Meunier, P.D. Delmas, Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J. Clin. Invest. 91(4), 1769–1774 (1993)
    • (1993) J. Clin. Invest. , vol.91 , Issue.4 , pp. 1769-1774
    • Szulc, P.1    Chapuy, M.C.2    Meunier, P.J.3    Delmas, P.D.4
  • 61
    • 0030444672 scopus 로고    scopus 로고
    • Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells
    • COI: 1:CAS:528:DyaK2sXpt1WktA%3D%3D, PID: 8968028
    • P. Szulc, P.D. Delmas, Influence of vitamin D and retinoids on the gammacarboxylation of osteocalcin in human osteosarcoma MG63 cells. Bone 19(6), 615–620 (1996)
    • (1996) Bone , vol.19 , Issue.6 , pp. 615-620
    • Szulc, P.1    Delmas, P.D.2
  • 62
    • 0028147029 scopus 로고
    • Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women
    • COI: 1:CAS:528:DyaK2MXhslCltLw%3D, PID: 7817805
    • P. Szulc, M. Arlot, M.C. Chapuy, F. Duboeuf, P.J. Meunier, P.D. Delmas, Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J. Bone Miner. Res. 9(10), 1591–1595 (1994)
    • (1994) J. Bone Miner. Res. , vol.9 , Issue.10 , pp. 1591-1595
    • Szulc, P.1    Arlot, M.2    Chapuy, M.C.3    Duboeuf, F.4    Meunier, P.J.5    Delmas, P.D.6
  • 63
    • 0025723423 scopus 로고
    • Impairment of gamma carboxylation of circulating osteocalcin (bone Gla protein) in elderly women
    • COI: 1:STN:280:DyaK383hsVantA%3D%3D, PID: 1666807
    • L. Plantalech, M. Guillaumont, P. Vergnaud, M. Leclercq, P.D. Delmas, Impairment of gamma carboxylation of circulating osteocalcin (bone Gla protein) in elderly women. J. Bone Miner. Res. 6(11), 1211–1216 (1991)
    • (1991) J. Bone Miner. Res. , vol.6 , Issue.11 , pp. 1211-1216
    • Plantalech, L.1    Guillaumont, M.2    Vergnaud, P.3    Leclercq, M.4    Delmas, P.D.5
  • 64
    • 0030607712 scopus 로고    scopus 로고
    • Osteocalcin detection in aging serum and whole blood: stability of different osteocalcin fractions
    • COI: 1:CAS:528:DyaK28Xnt1Kks7o%3D, PID: 9027426
    • M.H. Knapen, H.G. Eisenwiener, C. Vermeer, Osteocalcin detection in aging serum and whole blood: stability of different osteocalcin fractions. Clin. Chim. Acta 256(2), 151–164 (1996)
    • (1996) Clin. Chim. Acta , vol.256 , Issue.2 , pp. 151-164
    • Knapen, M.H.1    Eisenwiener, H.G.2    Vermeer, C.3
  • 65
    • 84877876790 scopus 로고    scopus 로고
    • The serum undercarboxylated osteocalcin level and the diet of a Japanese population: results from the Kyushu and Okinawa Population Study (KOPS)
    • COI: 1:CAS:528:DC%2BC38Xhtl2gtrvF, PID: 23001602
    • N. Furusyo, T. Ihara, T. Hayashi, H. Ikezaki, K. Toyoda, E. Ogawa, K. Okada, M. Kainuma, M. Murata, J. Hayashi, The serum undercarboxylated osteocalcin level and the diet of a Japanese population: results from the Kyushu and Okinawa Population Study (KOPS). Endocrine 43(3), 635–642 (2013)
    • (2013) Endocrine , vol.43 , Issue.3 , pp. 635-642
    • Furusyo, N.1    Ihara, T.2    Hayashi, T.3    Ikezaki, H.4    Toyoda, K.5    Ogawa, E.6    Okada, K.7    Kainuma, M.8    Murata, M.9    Hayashi, J.10
  • 66
    • 0031044021 scopus 로고    scopus 로고
    • Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study
    • COI: 1:CAS:528:DyaK2sXhsl2jsL4%3D, PID: 9062471
    • P. Vergnaud, P. Garnero, P.J. Meunier, G. Bréart, K. Kamihagi, P.D. Delmas, Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J. Clin. Endocrinol. Metab. 82(3), 719–724 (1997)
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , Issue.3 , pp. 719-724
    • Vergnaud, P.1    Garnero, P.2    Meunier, P.J.3    Bréart, G.4    Kamihagi, K.5    Delmas, P.D.6
  • 67
    • 0034980829 scopus 로고    scopus 로고
    • Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K
    • COI: 1:CAS:528:DC%2BD3MXlslWhu7c%3D, PID: 11368299
    • T. Sugiyama, S. Kawai, Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K. J. Bone Miner. Metab. 19(3), 146–149 (2001)
    • (2001) J. Bone Miner. Metab. , vol.19 , Issue.3 , pp. 146-149
    • Sugiyama, T.1    Kawai, S.2
  • 68
    • 84862744882 scopus 로고    scopus 로고
    • The endocrine role of the skeleton: background and clinical evidence
    • COI: 1:CAS:528:DC%2BC38Xpt1ertrc%3D, PID: 22436399
    • V. Schwetz, T. Pieber, B. Obermayer-Pietsch, The endocrine role of the skeleton: background and clinical evidence. Eur. J. Endocrinol. 166(6), 959–967 (2012)
    • (2012) Eur. J. Endocrinol. , vol.166 , Issue.6 , pp. 959-967
    • Schwetz, V.1    Pieber, T.2    Obermayer-Pietsch, B.3
  • 70
    • 2942519523 scopus 로고    scopus 로고
    • Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor
    • COI: 1:CAS:528:DC%2BD2cXkslOisb4%3D, PID: 15194188
    • P. Wellendorph, H. Brauner-Osborne, Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 335, 37–46 (2004)
    • (2004) Gene , vol.335 , pp. 37-46
    • Wellendorph, P.1    Brauner-Osborne, H.2
  • 71
    • 14944341203 scopus 로고    scopus 로고
    • Deorphanization of GPRC6A: a promiscuous l-alpha-amino acid receptor with preference for basic amino acids
    • COI: 1:CAS:528:DC%2BD2MXitlaqsrs%3D, PID: 15576628
    • P. Wellendorph, K.B. Hansen, A. Balsgaard, J.R. Greenwood, J. Egebjerg, H. Brauner-Osborne, Deorphanization of GPRC6A: a promiscuous l-alpha-amino acid receptor with preference for basic amino acids. Mol. Pharmacol. 67(3), 589–597 (2005)
    • (2005) Mol. Pharmacol. , vol.67 , Issue.3 , pp. 589-597
    • Wellendorph, P.1    Hansen, K.B.2    Balsgaard, A.3    Greenwood, J.R.4    Egebjerg, J.5    Brauner-Osborne, H.6
  • 73
    • 67649398909 scopus 로고    scopus 로고
    • Bone health in diabetes: considerations for clinical management
    • PID: 19292601
    • S. Adami, Bone health in diabetes: considerations for clinical management. Curr. Med. Res. Opin. 25(5), 1057–1072 (2009)
    • (2009) Curr. Med. Res. Opin. , vol.25 , Issue.5 , pp. 1057-1072
    • Adami, S.1
  • 74
    • 84897558108 scopus 로고    scopus 로고
    • Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation
    • COI: 1:CAS:528:DC%2BC2cXmtVGgtbo%3D
    • J. Wei, M. Ferron, C.J. Clarke, Y.A. Hannun, H. Jiang, W.S. Blaner, G. Karsenty, Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J. Clin. Invest. 124(4), 1781–1793 (2014)
    • (2014) J. Clin. Invest. , vol.124 , Issue.4 , pp. 1781-1793
    • Wei, J.1    Ferron, M.2    Clarke, C.J.3    Hannun, Y.A.4    Jiang, H.5    Blaner, W.S.6    Karsenty, G.7
  • 75
    • 84897563805 scopus 로고    scopus 로고
    • Insulin, osteoblasts, and energy metabolism: why bone counts calories
    • COI: 1:CAS:528:DC%2BC2cXmtVGgtrY%3D, PID: 24642463
    • R.C. Riddle, T.L. Clemens, Insulin, osteoblasts, and energy metabolism: why bone counts calories. J. Clin. Invest. 124(4), 1465–1467 (2014)
    • (2014) J. Clin. Invest. , vol.124 , Issue.4 , pp. 1465-1467
    • Riddle, R.C.1    Clemens, T.L.2
  • 76
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • COI: 1:CAS:528:DC%2BC3cXpsVahsr4%3D, PID: 20655470
    • M. Ferron, J. Wei, T. Yoshizawa, A. Del Fattore, R.A. DePinho, A. Teti, P. Ducy, G. Karsenty, Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142(2), 296–308 (2010)
    • (2010) Cell , vol.142 , Issue.2 , pp. 296-308
    • Ferron, M.1    Wei, J.2    Yoshizawa, T.3    Del Fattore, A.4    DePinho, R.A.5    Teti, A.6    Ducy, P.7    Karsenty, G.8
  • 77
    • 84889097382 scopus 로고    scopus 로고
    • In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice
    • COI: 1:CAS:528:DC%2BC3sXhsleju7%2FM, PID: 24327965
    • J. Lacombe, G. Karsenty, M. Ferron, In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice. Mol. Metab. 2(4), 498–504 (2013)
    • (2013) Mol. Metab. , vol.2 , Issue.4 , pp. 498-504
    • Lacombe, J.1    Karsenty, G.2    Ferron, M.3
  • 78
    • 42449096306 scopus 로고    scopus 로고
    • Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
    • COI: 1:CAS:528:DC%2BD1cXksVOns7Y%3D, PID: 18362359
    • M. Ferron, E. Hinoi, G. Karsenty, P. Ducy, Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105(13), 5266–5270 (2008)
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.13 , pp. 5266-5270
    • Ferron, M.1    Hinoi, E.2    Karsenty, G.3    Ducy, P.4
  • 79
    • 84894500766 scopus 로고    scopus 로고
    • Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a
    • COI: 1:CAS:528:DC%2BC2cXjs1Knsb4%3D, PID: 24009262
    • J. Wei, T. Hanna, N. Suda, G. Karsenty, P. Ducy, Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a. Diabetes 63(3), 1021–1031 (2014)
    • (2014) Diabetes , vol.63 , Issue.3 , pp. 1021-1031
    • Wei, J.1    Hanna, T.2    Suda, N.3    Karsenty, G.4    Ducy, P.5
  • 80
    • 77956737410 scopus 로고    scopus 로고
    • Bone and glucose metabolism: a two-way street
    • COI: 1:CAS:528:DC%2BC3cXhtFygtLvE, PID: 20682281
    • K.J. Motyl, L.R. McCabe, A.V. Schwartz, Bone and glucose metabolism: a two-way street. Arch. Biochem. Biophys. 503(1), 2–10 (2010)
    • (2010) Arch. Biochem. Biophys. , vol.503 , Issue.1 , pp. 2-10
    • Motyl, K.J.1    McCabe, L.R.2    Schwartz, A.V.3
  • 81
    • 70349226800 scopus 로고    scopus 로고
    • The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts
    • COI: 1:CAS:528:DC%2BD1MXhtFWgs7%2FJ, PID: 19726872
    • T. Yoshizawa, E. Hinoi, D.Y. Jung, D. Kajimura, M. Ferron, J. Seo, J.M. Graff, J.K. Kim, G. Karsenty, The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J. Clin. Invest. 119(9), 2807–2817 (2009)
    • (2009) J. Clin. Invest. , vol.119 , Issue.9 , pp. 2807-2817
    • Yoshizawa, T.1    Hinoi, E.2    Jung, D.Y.3    Kajimura, D.4    Ferron, M.5    Seo, J.6    Graff, J.M.7    Kim, J.K.8    Karsenty, G.9
  • 83
    • 0036963450 scopus 로고    scopus 로고
    • Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosis
    • COI: 1:CAS:528:DC%2BD38XitlWgs7o%3D, PID: 11889149
    • O. Johnell, W.H. Scheele, Y. Lu, J.Y. Reginster, A.G. Need, E. Seeman, Additive effects of raloxifene and alendronate on bone density and biochemical markers of bone remodeling in postmenopausal women with osteoporosis. J. Clin. Endocrinol. Metab. 87(3), 985–992 (2002)
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , Issue.3 , pp. 985-992
    • Johnell, O.1    Scheele, W.H.2    Lu, Y.3    Reginster, J.Y.4    Need, A.G.5    Seeman, E.6
  • 84
    • 43549085287 scopus 로고    scopus 로고
    • Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women
    • COI: 1:CAS:528:DC%2BD1cXls1Kntr4%3D, PID: 18470667
    • M. Hirao, J. Hashimoto, W. Ando, T. Ono, H. Yoshikawa, Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women. J. Bone Miner. Metab. 26(3), 260–264 (2008)
    • (2008) J. Bone Miner. Metab. , vol.26 , Issue.3 , pp. 260-264
    • Hirao, M.1    Hashimoto, J.2    Ando, W.3    Ono, T.4    Yoshikawa, H.5
  • 85
    • 68849102110 scopus 로고    scopus 로고
    • Low serum levels of undercarboxylated osteocalcin in postmenopausal osteoporotic women receiving an inhibitor of bone resorption
    • COI: 1:CAS:528:DC%2BD1MXptlWqurs%3D, PID: 19561390
    • H. Aonuma, N. Miyakoshi, M. Hongo, Y. Kasukawa, Y. Shimada, Low serum levels of undercarboxylated osteocalcin in postmenopausal osteoporotic women receiving an inhibitor of bone resorption. Tohoku J. Exp. Med. 218(3), 201–205 (2009)
    • (2009) Tohoku J. Exp. Med. , vol.218 , Issue.3 , pp. 201-205
    • Aonuma, H.1    Miyakoshi, N.2    Hongo, M.3    Kasukawa, Y.4    Shimada, Y.5
  • 86
    • 83155168441 scopus 로고    scopus 로고
    • Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1–84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study)
    • COI: 1:CAS:528:DC%2BC38XhtVw%3D, PID: 21994958
    • A.L. Schafer, D.E. Sellmeyer, A.V. Schwartz, C.J. Rosen, E. Vittinghoff, L. Palermo, J.P. Bilezikian, D.M. Shoback, D.M. Black, Change in undercarboxylated osteocalcin is associated with changes in body weight, fat mass, and adiponectin: parathyroid hormone (1–84) or alendronate therapy in postmenopausal women with osteoporosis (the PaTH study). J. Clin. Endocrinol. Metab. 96(12), E1982–E1989 (2011)
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , Issue.12 , pp. 1982-1989
    • Schafer, A.L.1    Sellmeyer, D.E.2    Schwartz, A.V.3    Rosen, C.J.4    Vittinghoff, E.5    Palermo, L.6    Bilezikian, J.P.7    Shoback, D.M.8    Black, D.M.9
  • 87
    • 34248592208 scopus 로고    scopus 로고
    • Monitoring of Risedronate by biochemical bone markers in clinical practice
    • PID: 17500121
    • N. Bunyaratavej, Monitoring of Risedronate by biochemical bone markers in clinical practice. J. Med. Assoc. Thai. 88(suppl 5), S34–S36 (2005)
    • (2005) J. Med. Assoc. Thai. , vol.88 , pp. 34-36
    • Bunyaratavej, N.1
  • 88
    • 84877726078 scopus 로고    scopus 로고
    • Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK(2)) in postmenopausal RA patients
    • COI: 1:CAS:528:DC%2BC3sXnsFGitLg%3D, PID: 22692649
    • K. Suzuki, S. Tsuji, Y. Fukushima, T. Nakase, M. Hamada, T. Tomita, H. Yoshikawa, Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK(2)) in postmenopausal RA patients. Mod. Rheumatol. 23(3), 450–455 (2013)
    • (2013) Mod. Rheumatol. , vol.23 , Issue.3 , pp. 450-455
    • Suzuki, K.1    Tsuji, S.2    Fukushima, Y.3    Nakase, T.4    Hamada, M.5    Tomita, T.6    Yoshikawa, H.7
  • 89
    • 77956929105 scopus 로고    scopus 로고
    • High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment
    • COI: 1:CAS:528:DC%2BC3cXhtFamtLnJ, PID: 20221651
    • M. Shiraki, Y. Yamazaki, Y. Shiraki, T. Hosoi, N. Tsugawa, T. Okano, High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment. J. Bone Miner. Metab. 28(5), 578–584 (2010)
    • (2010) J. Bone Miner. Metab. , vol.28 , Issue.5 , pp. 578-584
    • Shiraki, M.1    Yamazaki, Y.2    Shiraki, Y.3    Hosoi, T.4    Tsugawa, N.5    Okano, T.6
  • 90
    • 82755193783 scopus 로고    scopus 로고
    • Risk of newly diagnosed type 2 diabetes is reduced in users of alendronate
    • COI: 1:CAS:528:DC%2BC3MXhtFyktrrF, PID: 21710315
    • P. Vestergaard, Risk of newly diagnosed type 2 diabetes is reduced in users of alendronate. Calcif. Tissue Int. 89(4), 265–270 (2011)
    • (2011) Calcif. Tissue Int. , vol.89 , Issue.4 , pp. 265-270
    • Vestergaard, P.1
  • 91
    • 41749123776 scopus 로고    scopus 로고
    • Influence of type 2 diabetes mellitus on bone mineral density response to bisphosphonates in late postmenopausal osteoporosis
    • COI: 1:CAS:528:DC%2BD1cXitlGks7k%3D, PID: 18165214
    • S. Dagdelen, D. Sener, M. Bayraktar, Influence of type 2 diabetes mellitus on bone mineral density response to bisphosphonates in late postmenopausal osteoporosis. Adv. Ther. 24(6), 1314–1320 (2007)
    • (2007) Adv. Ther. , vol.24 , Issue.6 , pp. 1314-1320
    • Dagdelen, S.1    Sener, D.2    Bayraktar, M.3
  • 93
    • 69249205598 scopus 로고    scopus 로고
    • A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms
    • COI: 1:CAS:528:DC%2BD1MXhtVKlsr%2FK, PID: 19376193
    • C.B. Confavreux, R.L. Levine, G. Karsenty, A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms. Mol. Cell. Endocrinol. 310(1–2), 21–29 (2009)
    • (2009) Mol. Cell. Endocrinol. , vol.310 , Issue.1-2 , pp. 21-29
    • Confavreux, C.B.1    Levine, R.L.2    Karsenty, G.3
  • 94
    • 84863863767 scopus 로고    scopus 로고
    • The relationship between adipose tissue and bone metabolism
    • COI: 1:CAS:528:DC%2BC38XkvFSqtbw%3D, PID: 22429519
    • J.M. Gimble, M.E. Nuttall, The relationship between adipose tissue and bone metabolism. Clin. Biochem. 45(12), 874–879 (2012)
    • (2012) Clin. Biochem. , vol.45 , Issue.12 , pp. 874-879
    • Gimble, J.M.1    Nuttall, M.E.2
  • 95
    • 23844554138 scopus 로고    scopus 로고
    • Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy
    • PID: 16055699
    • J.F. Griffith, D.K. Yeung, G.E. Antonio, F.K. Lee, A.W. Hong, S.Y. Wong, E.M. Lau, P.C. Leung, Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 236(3), 945–951 (2005)
    • (2005) Radiology , vol.236 , Issue.3 , pp. 945-951
    • Griffith, J.F.1    Yeung, D.K.2    Antonio, G.E.3    Lee, F.K.4    Hong, A.W.5    Wong, S.Y.6    Lau, E.M.7    Leung, P.C.8
  • 96
    • 50949118377 scopus 로고    scopus 로고
    • Regulation of bone remodeling by the central and peripheral nervous system
    • COI: 1:CAS:528:DC%2BD1cXlsFOgur0%3D, PID: 18410742
    • F. Elefteriou, Regulation of bone remodeling by the central and peripheral nervous system. Arch. Biochem. Biophys. 473(2), 231–236 (2008)
    • (2008) Arch. Biochem. Biophys. , vol.473 , Issue.2 , pp. 231-236
    • Elefteriou, F.1
  • 98
    • 0141737573 scopus 로고    scopus 로고
    • Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
    • COI: 1:CAS:528:DC%2BD3cXotFChsw%3D%3D, PID: 10660043
    • P. Ducy, M. Amling, S. Takeda, M. Priemel, A.F. Schilling, F.T. Beil, J. Shen, C. Vinson, J.M. Rueger, G. Karsenty, Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100(2), 197–207 (2000)
    • (2000) Cell , vol.100 , Issue.2 , pp. 197-207
    • Ducy, P.1    Amling, M.2    Takeda, S.3    Priemel, M.4    Schilling, A.F.5    Beil, F.T.6    Shen, J.7    Vinson, C.8    Rueger, J.M.9    Karsenty, G.10
  • 101
    • 84866136855 scopus 로고    scopus 로고
    • Understanding leptin-dependent regulation of skeletal homeostasis
    • COI: 1:CAS:528:DC%2BC38Xms12lur8%3D, PID: 22534195
    • K.J. Motyl, C.J. Rosen, Understanding leptin-dependent regulation of skeletal homeostasis. Biochimie 94(10), 2089–2096 (2012)
    • (2012) Biochimie , vol.94 , Issue.10 , pp. 2089-2096
    • Motyl, K.J.1    Rosen, C.J.2
  • 102
    • 84900484769 scopus 로고    scopus 로고
    • Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes
    • COI: 1:CAS:528:DC%2BC2cXhvVekur%2FO, PID: 24554534
    • H.S. Hill, J. Grams, R.G. Walton, J. Liu, D.R. Moellering, W.T. Garvey, Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes. Horm. Metab. Res. 46(5), 341–347 (2014)
    • (2014) Horm. Metab. Res. , vol.46 , Issue.5 , pp. 341-347
    • Hill, H.S.1    Grams, J.2    Walton, R.G.3    Liu, J.4    Moellering, D.R.5    Garvey, W.T.6
  • 103
    • 84864401942 scopus 로고    scopus 로고
    • Bone and energy metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race
    • COI: 1:CAS:528:DC%2BC38XhtFCgur7L, PID: 22848709
    • G. Lombardi, P. Lanteri, G. Graziani, A. Colombini, G. Banfi, R. Corsetti, Bone and energy metabolism parameters in professional cyclists during the Giro d’Italia 3-weeks stage race. PLoS ONE 7(7), e42077 (2012)
    • (2012) PLoS ONE , vol.7 , Issue.7 , pp. 42077
    • Lombardi, G.1    Lanteri, P.2    Graziani, G.3    Colombini, A.4    Banfi, G.5    Corsetti, R.6
  • 104
    • 84862065611 scopus 로고    scopus 로고
    • The mutual dependence between bone and gonads
    • COI: 1:CAS:528:DC%2BC38XotVOrs7g%3D, PID: 22407998
    • G. Karsenty, The mutual dependence between bone and gonads. J. Endocrinol. 213(2), 107–114 (2012)
    • (2012) J. Endocrinol. , vol.213 , Issue.2 , pp. 107-114
    • Karsenty, G.1
  • 105
    • 84890803784 scopus 로고    scopus 로고
    • Serum concentrations of fully and undercarboxylated osteocalcin do not vary between estrous cycle stages in Sprague-Dawley rats
    • COI: 1:CAS:528:DC%2BC3sXhtVeht7rP, PID: 23817840
    • B.V. Rosa, H.T. Blair, M.H. Vickers, C.G. Knight, P.C. Morel, E.C. Firth, Serum concentrations of fully and undercarboxylated osteocalcin do not vary between estrous cycle stages in Sprague-Dawley rats. Endocrine 44(3), 809–811 (2013)
    • (2013) Endocrine , vol.44 , Issue.3 , pp. 809-811
    • Rosa, B.V.1    Blair, H.T.2    Vickers, M.H.3    Knight, C.G.4    Morel, P.C.5    Firth, E.C.6
  • 107
    • 84888306434 scopus 로고    scopus 로고
    • Regulation of male fertility by the bone-derived hormone osteocalcin
    • COI: 1:CAS:528:DC%2BC3sXhs12lurbE, PID: 24145129
    • G. Karsenty, F. Oury, Regulation of male fertility by the bone-derived hormone osteocalcin. Mol. Cell. Endocrinol. 382(1), 521–526 (2014)
    • (2014) Mol. Cell. Endocrinol. , vol.382 , Issue.1 , pp. 521-526
    • Karsenty, G.1    Oury, F.2
  • 108
    • 84882759617 scopus 로고    scopus 로고
    • Serum osteocalcin is associated with improved metabolic state via adiponectin in females versus testosterone in males. Gender specific nature of the bone-energy homeostasis axis
    • COI: 1:CAS:528:DC%2BC3sXhsV2ms7vK, PID: 23886839
    • B. Buday, F.P. Pach, B. Literati-Nagy, M. Vitai, Z. Vecsei, L. Koranyi, Serum osteocalcin is associated with improved metabolic state via adiponectin in females versus testosterone in males. Gender specific nature of the bone-energy homeostasis axis. Bone 57(1), 98–104 (2013)
    • (2013) Bone , vol.57 , Issue.1 , pp. 98-104
    • Buday, B.1    Pach, F.P.2    Literati-Nagy, B.3    Vitai, M.4    Vecsei, Z.5    Koranyi, L.6
  • 110
    • 84910142891 scopus 로고    scopus 로고
    • Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role?
    • PID: 24802058
    • N.S. Datta, Muscle-bone and fat-bone interactions in regulating bone mass: do PTH and PTHrP play any role? Endocrine (2014). doi:10.1007/s12020-014-0273-3
    • (2014) Endocrine
    • Datta, N.S.1
  • 112
    • 0347478017 scopus 로고    scopus 로고
    • Muscle sarcopenia: an overview
    • COI: 1:STN:280:DC%2BD2c%2FntFOgtQ%3D%3D, PID: 14959562
    • S.K. Mishra, V. Misra, Muscle sarcopenia: an overview. Acta Myol. 22(2), 43–47 (2003)
    • (2003) Acta Myol. , vol.22 , Issue.2 , pp. 43-47
    • Mishra, S.K.1    Misra, V.2
  • 113
    • 33646902419 scopus 로고    scopus 로고
    • Inflammatory markers and loss of muscle mass (sarcopenia) and strength
    • L.A. Schaap, S.M. Pluijm, D.J. Deeg, M. Visser, Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am. J. Med. 119(6), 526.e9–526.e17 (2006)
    • (2006) Am. J. Med. , vol.119 , Issue.6
    • Schaap, L.A.1    Pluijm, S.M.2    Deeg, D.J.3    Visser, M.4
  • 114
    • 79955466529 scopus 로고    scopus 로고
    • The effect of acute exercise on undercarboxylated osteocalcin in obese men
    • COI: 1:CAS:528:DC%2BC3MXksFSjsL4%3D, PID: 20734028
    • I. Levinger, R. Zebaze, G. Jerums, D.L. Hare, S. Selig, E. Seeman, The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporos. Int. 22(5), 1621–1626 (2011)
    • (2011) Osteoporos. Int. , vol.22 , Issue.5 , pp. 1621-1626
    • Levinger, I.1    Zebaze, R.2    Jerums, G.3    Hare, D.L.4    Selig, S.5    Seeman, E.6
  • 117
    • 84869118339 scopus 로고    scopus 로고
    • Normal vascular function as a prerequisite for the absence of coronary calcification in patients free of cardiovascular disease and diabetes
    • PID: 22850339
    • J. Li, A.J. Flammer, R.E. Nelson, R. Gulati, P.A. Friedman, R.J. Thomas, N.P. Sandhu, M.K. Reriani, L.O. Lerman, A. Lerman, Normal vascular function as a prerequisite for the absence of coronary calcification in patients free of cardiovascular disease and diabetes. Circ. J. 76(11), 2705–2710 (2012)
    • (2012) Circ. J. , vol.76 , Issue.11 , pp. 2705-2710
    • Li, J.1    Flammer, A.J.2    Nelson, R.E.3    Gulati, R.4    Friedman, P.A.5    Thomas, R.J.6    Sandhu, N.P.7    Reriani, M.K.8    Lerman, L.O.9    Lerman, A.10
  • 118
    • 84870501462 scopus 로고    scopus 로고
    • Balanced mineralization in the arterial system: possible role of osteoclastogenesis/osteoblastogenesis in abdominal aortic aneurysm and stenotic disease
    • COI: 1:CAS:528:DC%2BC3sXhsVGltA%3D%3D, PID: 23117745
    • D. Yamanouchi, Y. Takei, K. Komori, Balanced mineralization in the arterial system: possible role of osteoclastogenesis/osteoblastogenesis in abdominal aortic aneurysm and stenotic disease. Circ. J. 76(12), 2732–2737 (2012)
    • (2012) Circ. J. , vol.76 , Issue.12 , pp. 2732-2737
    • Yamanouchi, D.1    Takei, Y.2    Komori, K.3
  • 119
    • 47249089087 scopus 로고    scopus 로고
    • Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles
    • COI: 1:CAS:528:DC%2BD1cXlvFyjt7o%3D, PID: 18364352
    • A. Heiss, T. Eckert, A. Aretz, W. Richtering, W. van Dorp, C. Schafer, W. Jahnen-Dechent, Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J. Biol. Chem. 283(21), 14815–14825 (2008)
    • (2008) J. Biol. Chem. , vol.283 , Issue.21 , pp. 14815-14825
    • Heiss, A.1    Eckert, T.2    Aretz, A.3    Richtering, W.4    van Dorp, W.5    Schafer, C.6    Jahnen-Dechent, W.7
  • 120
    • 84866296098 scopus 로고    scopus 로고
    • The role of vitamin K in soft-tissue calcification
    • COI: 1:CAS:528:DC%2BC38XmtVGrsL0%3D, PID: 22516724
    • E. Theuwissen, E. Smit, C. Vermeer, The role of vitamin K in soft-tissue calcification. Adv. Nutr. 3(2), 166–173 (2012)
    • (2012) Adv. Nutr. , vol.3 , Issue.2 , pp. 166-173
    • Theuwissen, E.1    Smit, E.2    Vermeer, C.3
  • 121
    • 84875276069 scopus 로고    scopus 로고
    • Visualizing novel concepts of cardiovascular calcification
    • COI: 1:CAS:528:DC%2BC3sXktlOjsbc%3D, PID: 23290463
    • J. Hjortnaes, S.E. New, E. Aikawa, Visualizing novel concepts of cardiovascular calcification. Trends Cardiovasc. Med. 23(3), 71–79 (2013)
    • (2013) Trends Cardiovasc. Med. , vol.23 , Issue.3 , pp. 71-79
    • Hjortnaes, J.1    New, S.E.2    Aikawa, E.3
  • 124
    • 33846429618 scopus 로고    scopus 로고
    • Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    • COI: 1:CAS:528:DC%2BD2sXlt1yrsA%3D%3D, PID: 17224478
    • E. Aikawa, M. Nahrendorf, D. Sosnovik, V.M. Lok, F.A. Jaffer, M. Aikawa, R. Weissleder, Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115(3), 377–386 (2007)
    • (2007) Circulation , vol.115 , Issue.3 , pp. 377-386
    • Aikawa, E.1    Nahrendorf, M.2    Sosnovik, D.3    Lok, V.M.4    Jaffer, F.A.5    Aikawa, M.6    Weissleder, R.7
  • 125
  • 126
    • 67650559446 scopus 로고    scopus 로고
    • Mineralization by inhibitor exclusion: the calcification of collagen with fetuin
    • COI: 1:CAS:528:DC%2BD1MXntFCjt7Y%3D, PID: 19414589
    • P.A. Price, D. Toroian, J.E. Lim, Mineralization by inhibitor exclusion: the calcification of collagen with fetuin. J. Biol. Chem. 284(25), 17092–17101 (2009)
    • (2009) J. Biol. Chem. , vol.284 , Issue.25 , pp. 17092-17101
    • Price, P.A.1    Toroian, D.2    Lim, J.E.3
  • 127
    • 8644252020 scopus 로고    scopus 로고
    • Oral anticoagulant treatment: friend or foe in cardiovascular disease?
    • COI: 1:CAS:528:DC%2BD2cXhtVWhurrM, PID: 15265793
    • L.J. Schurgers, H. Aebert, C. Vermeer, B. Bultmann, J. Janzen, Oral anticoagulant treatment: friend or foe in cardiovascular disease? Blood 104(10), 3231–3232 (2004)
    • (2004) Blood , vol.104 , Issue.10 , pp. 3231-3232
    • Schurgers, L.J.1    Aebert, H.2    Vermeer, C.3    Bultmann, B.4    Janzen, J.5
  • 128
    • 24944476584 scopus 로고    scopus 로고
    • Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography
    • COI: 1:CAS:528:DC%2BD2MXhtVWnsbjF, PID: 16169351
    • R. Koos, A.H. Mahnken, G. Muhlenbruch, V. Brandenburg, B. Pflueger, J.E. Wildberger, H.P. Kuhl, Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography. Am. J. Cardiol. 96(6), 747–749 (2005)
    • (2005) Am. J. Cardiol. , vol.96 , Issue.6 , pp. 747-749
    • Koos, R.1    Mahnken, A.H.2    Muhlenbruch, G.3    Brandenburg, V.4    Pflueger, B.5    Wildberger, J.E.6    Kuhl, H.P.7
  • 129
    • 78649450075 scopus 로고    scopus 로고
    • Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation
    • PID: 20817370
    • M. Hristova, C. van Beek, L.J. Schurgers, B. Lanske, J. Danziger, Rapidly progressive severe vascular calcification sparing the kidney allograft following warfarin initiation. Am. J. Kidney Dis. 56(6), 1158–1162 (2010)
    • (2010) Am. J. Kidney Dis. , vol.56 , Issue.6 , pp. 1158-1162
    • Hristova, M.1    van Beek, C.2    Schurgers, L.J.3    Lanske, B.4    Danziger, J.5
  • 130
    • 77954677816 scopus 로고    scopus 로고
    • Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans
    • COI: 1:CAS:528:DC%2BC3cXos1Kqtr8%3D, PID: 20354170
    • R.J. Rennenberg, B.J. van Varik, L.J. Schurgers, K. Hamulyak, H. Ten Cate, T. Leiner, C. Vermeer, P.W. de Leeuw, A.A. Kroon, Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood 115(24), 5121–5123 (2010)
    • (2010) Blood , vol.115 , Issue.24 , pp. 5121-5123
    • Rennenberg, R.J.1    van Varik, B.J.2    Schurgers, L.J.3    Hamulyak, K.4    Ten Cate, H.5    Leiner, T.6    Vermeer, C.7    de Leeuw, P.W.8    Kroon, A.A.9
  • 131
    • 80054735097 scopus 로고    scopus 로고
    • Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients
    • COI: 1:CAS:528:DC%2BC3MXhtlaqt7rK, PID: 21775389
    • B. Weijs, Y. Blaauw, R.J. Rennenberg, L.J. Schurgers, C.C. Timmermans, L. Pison, R. Nieuwlaat, L. Hofstra, A.A. Kroon, J. Wildberger, H.J. Crijns, Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients. Eur. Heart J. 32(20), 2555–2562 (2011)
    • (2011) Eur. Heart J. , vol.32 , Issue.20 , pp. 2555-2562
    • Weijs, B.1    Blaauw, Y.2    Rennenberg, R.J.3    Schurgers, L.J.4    Timmermans, C.C.5    Pison, L.6    Nieuwlaat, R.7    Hofstra, L.8    Kroon, A.A.9    Wildberger, J.10    Crijns, H.J.11
  • 132
    • 84866279334 scopus 로고    scopus 로고
    • Vitamin K-dependent carboxylation of osteocalcin: friend or foe?
    • COI: 1:CAS:528:DC%2BC38XmtVGrs7k%3D, PID: 22516722
    • C.M. Gundberg, J.B. Lian, S.L. Booth, Vitamin K-dependent carboxylation of osteocalcin: friend or foe? Adv. Nutr. 3(2), 149–157 (2012)
    • (2012) Adv. Nutr. , vol.3 , Issue.2 , pp. 149-157
    • Gundberg, C.M.1    Lian, J.B.2    Booth, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.