Inhibited and uninhibited platelet deposition within a thrombus does it depend on the antiplatelet drug?

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 10, 2015, Pages 2081-2082

  Gurbel, Paul A ^a   Tantry, Udaya S ^a  

^a INOVA HEART AND VASCULAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DINORTHROMBOXANE B2; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CYCLOOXYGENASE 1; FIBRIN; PRASUGREL; PURINERGIC P2Y12 RECEPTOR; THIENOPYRIDINE DERIVATIVE; THROMBIN; THROMBOXANE A2;

CONFOCAL MICROSCOPY; EDITORIAL; ENZYME INHIBITION; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA; THROMBUS; TREATMENT FAILURE; DRUG EFFECTS; THROMBOCYTE;

ASPIRIN; BLOOD PLATELETS; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE;

EID: 84942292039     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.306371     Document Type: Editorial

References (8)

1. Gurbel PA, Tantry US. Combination antithrombotic therapies. Circulation. 2010;121:569-583. doi: 10. 1161/CIRCULATIONAHA. 109. 853085.
2. Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003;107:2908-2913. doi: 10. 1161/01. CIR. 0000072771. 11429. 83.
3. Gurbel PA, Tantry US. Do platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents? Platelet function testing and genotyping improve outcome in patients treated with antithrombotic agents. Circulation. 2012;125:1276-1287; discussion 1287. doi: 10. 1161/CIRCULATIONAHA. 111. 031195.
4. Gurbel PA, Tantry US. Antiplatelet and anticoagulant agents in heart failure: current status and future perspectives. JACC Heart Fail. 2014;2:1-14. doi: 10. 1016/j. jchf. 2013. 07. 007.
5. Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD. Drug-free platelets can act as seeds for aggregate formation during antiplatelet therapy. Arterioscler Thromb Vasc Biol. 2015;35:2122-2133. doi: 10. 1161/ATVBAHA. 115. 306219.
6. Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest. 1982;69:1366-1372.
7. Patrick J, Dillaha L, Armas D, Sessa WC. A randomized trial to assess the pharmacodynamics and pharmacokinetics of a single dose of an extended-release aspirin formulation. Postgrad Med. 2015;127:573-580. doi: 10. 1080/00325481. 2015. 1050341.
8. Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. J Am Coll Cardiol. 2005;46:1705-1709. doi: 10. 1016/j. jacc. 2005. 05. 090.