Efficacy of mesalazine or beclomethasone dipropionate enema or their combination in patients with distal active ulcerative colitis

European Review for Medical and Pharmacological Sciences

Volumn 19, Issue 15, 2015, Pages 2830-2837

  Crispino, P ^a   Pica, R ^a   Unim, H ^a   Rivera, M ^a   Cassieri, C ^a   Zippi, M ^a   Paoluzi, P ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Beclometasone dipropionate; Mesalazine; Topical treatment; Ulcerative colitis

Indexed keywords

BECLOMETASONE DIPROPIONATE; ENEMA; MESALAZINE; ANTIINFLAMMATORY AGENT; BECLOMETASONE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EFFICACY; DRUG TOLERABILITY; EVENING DOSAGE; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; RANDOMIZED CONTROLLED TRIAL; REMISSION; TABLET; TREATMENT DURATION; ULCERATIVE COLITIS; AGED; COLITIS, ULCERATIVE; COMBINATION DRUG THERAPY; FOLLOW UP; MIDDLE AGED; PROCEDURES; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; BECLOMETHASONE; COLITIS, ULCERATIVE; DRUG THERAPY, COMBINATION; ENEMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MESALAMINE; MIDDLE AGED; REMISSION INDUCTION; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 84942278716     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. COHEN RD, WOSETH DM, THISTED RA, HANAUER SB. A meta-analysis and overview of the literature on treatment options for left-sided ulcerative colitis and ulcerative proctitis. Am J Gastroenterol 2000; 95: 1263-1276.
2. FARREL RJ, PEPPERCORN MA. Ulcerative colitis. Lancet 2002; 359: 331-340.
3. TRAVIS SP, STANGE EF, LÉMANN M, ORESLAND T, BEMELMAN WA, CHOWERS Y, COLOMBEL JF, D'HAENS G, GHOSH S, MARTEAU P, KRUIS W, MORTENSEN NJ, PENNINCKX F, GASSULL M; EUROPEAN CROHN'S AND COLITIS ORGANISATION (ECCO). European evidence-based Consensus on the management of ulcerative colitis: Current management. J Crohn Colitis 2008; 2: 24-62.
4. SAFDI M, DEMICCO M, SNINSKY C, BANKS P, WRUBLE L, DEREN J, KOVAL G, NICHOLS T, TARGAN S, FLEISHMAN C, WIITA B. A double-blind comparison of oral versus rectal mesalamine versus combination therapy in the treatment of distal ulcerative colitis. Am J Gastroenterol 1997; 92: 1867-1871.
5. FRIERI G, PIMPO MT, PALOMBO GC, ONORI L, VISCIDO A, LATELLA G, GALLETTI B, PANTALEONI GC, CAPRILLI R. Rectal and colonic mesalazine concentration in ulcerative colitis: oral vs oral plus topical treatment. Aliment Pharmacol Ther 1999; 13: 1413-1417.
6. MARSHALL JK, IRVINE EJ. Rectal aminosalicylate therapy for distal ulcerative colitis: a meta-analysis. Aliment Pharmacol Ther 1995; 9: 293-300.
7. MARSHALL JK, IRVINE EJ. Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis. Gut 1997; 40: 775-781.
8. RUTGEERTS P. Medical therapy of inflammatory bowel disease. Digestion 1998; 59: 453-469.
9. PODOLSKY DK. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429.
10. TRUELOVE SC. Systemic and local corticosteroids therapy in ulcerative colitis. Br Med J 1960; 1: 464-467.
11. RESHEF R, VARKEL J, SHILLER M, LOBERANT N. Systemic effects of rectally administered corticosteroid. Isr J Med Sci 1992; 28: 98-100.
12. BANSKY G, BUHLER H, STAMM B, ET AL. Treatment of distal ulcerative colitis with beclomethasone enemas: high therapeutic efficacy without endocrine side effects. A prospective, randomised, double blind trial. Dis Colon Rectum 1987; 30: 288-292.
13. KUMANA CR, SEATON T, MEGHJI M, CASTELLI M, BENSON R, SIVAKUMARAN T. Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushing's syndrome or hypothalamic pituitary adrenal suppression. Lancet 1982; 1: 579-583.
14. GIONCHETTI P, RIZZELLO F, HABAL F, MORSELLI C, AMADINI C, ROMAGNOLI R, CAMPIERI M. Standard treatment of ulcerative colitis. Dig Dis 2003; 21: 157-167.
15. FOE K, BROWN KF, SEALE JP. Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma. J Pharm Sci 2000; 89: 1143-1150.
16. D'ARIENZO A, MANGUSO F, CASTIGLIONE GN, VICINANZA G, SCAGLIONE G, BENNATO R, SANGES M, MAZZACCA G. Beclomethasone dipropionate (3 mg) enemas combined with oral 5-ASA (2.4 g) in the treatment of ulcerative colitis not responsive to oral 5-ASA alone. Ital J Gastroenterol Hepatol 1998; 30: 254-257.
17. DALEY-YATES PT, PRICE AC, SISSON JR, PEREIRA A, DALLOW N. Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. Br J Clin Pharmacol 2001; 51: 400-409.
18. MULDER CJ, ENDERT E, VAN DER HEIDE H, HOUTHOFF HJ, WIERSINGA W, WILTINK EH, TYTGAT GN. Comparison of beclomethasone dipropionate (2 and 3 mg) and prednisolone sodium phosphate enemas (30 mg) in the treatment of ulcerative proctitis: an adrenocortical approach. Neth J Med 1989; 35: 18-24.
19. HARRIS DM. Some properties of beclomethasone dipropionate and related steroids in man. Postgrad Med J 1975; 51: 20-25.
20. VIGNOTTI D, RANZI T, CAMPANINI MC, LISCIANDRANO D, MONTI GB, BIANCHI PA. Topical treatment of active distal ulcerative colitis with beclomethasone dipropionate. Curr Ther Res 1992; 52: 659-665.
21. CAMPIERI M, COTTONE M, ASTEGIANO M, MANENTI F, ASTEGIANO M, D'ARIENZO A, MANGUSO F, D'ALBASIO G, BONANOMI A, GALEAZZI R, ORLANDO A, CASTIGLIONE GN, GIONCHETTI P. Beclomethasone dipropionate enemas versus prednisolone sodium phosphate enemas in the treatment of distal ulcerative colitis. Aliment Pharmacol Ther 1998; 12: 361-366.
22. VAN DER HEIDE H, VAN DEN BRANDT-GRADEL V, TYTGAT GN, ENDERT E, WILTINK EH, SCHIPPER ME, DEKKER W. Comparison of beclomethasone dipropionate and prednisolone 21-phosphate enemas in the treatment of ulcerative proctitis. J Clin Gastroenterol 1988; 10: 169-172.
23. MULDER CJ, FOCKENS P, MEIJER JWR, VAN DER HEIDE H, WILTINK EHH, TYTGAT NJ. Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg/2 g) as retention enemas in active ulcerative proctitis. Eur J Gastroenterol Hepatol 1996; 8: 549-553.
24. MANGUSO F, BALZANO A. Meta-analysis: the efficacy of rectal beclomethasone dipropionate vs. 5-aminosalicylic acid in mild to moderate distal ulcerative colitis. Aliment Pharmacol Ther 2007; 26: 21-29.
25. RACHMILEWITZ D. Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. Br Med J 1989; 298: 82-86.
26. BARON JH, CONNELL AM, LENNARD-JONES JE. Variation between observers in describing mucosal appearances in proctocolitis. Br Med J 1964; 1: 89-92.
27. TRUELOVE SC, RICHARDS WC. Biopsy studies in ulcerative colitis. Br Med J 1956; 1: 1315-1318.
28. CAMPIERI M, LANFRANCHI GA, BRIGNOLA C, BAZZOCCHI G, GIONCHETTI P, MINGUZZI MR, CAPPELLO IP, CORBELLI C, BOSCHI S. Retrograde spread of 5-aminosalicylic acid enemas in patients with active ulcerative colitis. Dis Colon Rectum 1986; 29: 108-110.
29. CAMPIERI M, CORBELLI C, GIONCHETTI P, BRIGNOLA C, BELLUZZI A, DI FEBO G, ZAGNI P, BRUNETTI G, MIGLIOLI M, BARBARA L. Spread and distribution of 5-ASA colonic foam and 5-ASA enema in patients with ulcerative colitis. Dig Dis Sci 1992; 37: 1890-1897.
30. LEMANN M, GALIAN A, RUTGEERTS P VAN HEUVERZWIJN R, CORTOT A, VITEAU JM, ELEWAUT A, BELAICHE J, FROGUEL E, MODIGLIANI R. Comparison of budesonide and 5-aminosalicylic acid enemas in active distal ulcerative colitis. Aliment Pharmacol Ther 1995; 9: 557-562.
31. BIDDLE WL, MINER PB JR. Long-term use of mesalamine enemas to induce remission in ulcerative colitis. Gastroenterology 1990; 99: 113-118.
32. BIANCHI PORRO G, ARDIZZONE S, PETRILLO M, ET AL. Low Pentasa dosage versus hydrocortisone in the topical treatment of active ulcerative colitis: a randomised, double-blind study. Am J Gastroenterol 1995; 90: 736-739.
33. LEVINE DS, RAISYS VA, AINARDI V. Coating of oral beclomethasone dipropionate capsules with cellulose acetate phthalate enhances delivery of topically active anti-inflammatory drug to terminal ileum, Gastroenterology 1987; 92: 1037-1044.
34. GIONCHETTI P, D'ARIENZO A, RIZZELLO F, MANGUSO F, MAIERON R, LECIS PE, VALPIANI D, IAQUINTO G, ANNESE V, BALZANO A, VAROLI G, CAMPIERI M; ITALIAN BDP STUDY GROUP. Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalazine: a single-blind randomized controlled trial, J Clin Gastroenterol 2005; 39: 291-297.
35. BIANCONE L, GIONCHETTI P, BLANCO DEL VECCHIO G, ORLANDO A, ANNESE V, PAPI C, SOSTEGNI R, D'INCA R, PETRUZZIELLO C, CASA A, SICA G, CALABRESE E, CAMPIERI M, PALLONE F. Beclomethasone dipropionate versus mesalazine in distal ulcerative colitis: a multicenter, randomized, double-blind study. Dig Liver Dis. 2007; 39: 329-337.
36. PAOLUZI P, D'ALBASIO G, PERA A, BIANCHI PORRO G, PAOLUZI OA, PICA R COTTONE M, MIGLIOLI M, PRANTERA C, STURNIOLO G, ARDIZZONE S. Oral and topical 5-aminosalicylic acid (mesalazine) in inducing and maintaining remission in mild-moderate relapse of ulcerative colitis: one-year randomised multicentre trial. Dig Liver Dis 2002; 34: 787-793.