Spatial distribution of soluble insulin in pig subcutaneous tissue: Effect of needle length, injection speed and injected volume

European Journal of Pharmaceutical Sciences

Volumn 79, Issue , 2015, Pages 96-101

  Thomsen, Maria ^a,b   Rasmussen, Christian Hove ^a   Refsgaard, Hanne H F ^a   Pedersen, Karen Margrethe ^a   Kirk, Rikke K ^a   Poulsen, Mette ^a   Feidenhans'L, Robert ^b  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Drug distribution; Insulin aspart; Subcutaneous injections; X ray computed tomography

Indexed keywords

INSULIN;

ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DERMIS; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; EX VIVO STUDY; IMAGE RECONSTRUCTION; MUSCLE TISSUE; NEEDLE; NONHUMAN; PIG; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUBCUTANEOUS FAT; SUBCUTANEOUS TISSUE; ANIMAL; DEVICES; METABOLISM; PROCEDURES; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; INJECTIONS, SUBCUTANEOUS; INSULIN; NEEDLES; SUBCUTANEOUS TISSUE; SWINE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84942259448     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2015.08.012     Document Type: Article

References (31)

1. M.L. Bouxsein, S.K. Boyd, B.A. Christiansen, R.E. Guldberg, K.J. Jepsen, and R. Müller Guidelines for assessment of bone microstructure in rodents using micro-computed tomography J. Bone Miner. Res. 25 7 2010 1468 1486
2. J. Brange, U. Ribel, J. Hansen, G. Dodson, M. Hansen, S. Havelund, S. Melberg, F. Norris, K. Norris, L. Snel, and et al. Monomeric insulins obtained by protein engineering and their medical implications Nature 333 1988 (June)
3. G.M. Campbell, and A. Sophocleous Quantitative analysis of bone and soft tissue by micro-computed tomography: applications to ex vivo and in vivo studies BoneKEy Rep. 3 2014
4. E. Cengiz, S.A. Weinzimer, J.L. Sherr, E.M. Tichy, L. Carria, D. Cappiello, A. Steffen, and W.V. Tamborlane Faster in and faster out: accelerating insulin absorption and action by insulin infusion site warming Diabetes Technol. Ther. 16 1 2014 20 25
5. A.L. Dahl, and R. Larsen Learning dictionaries of discriminative image patches 22nd British Machine Vision Conference 2011
6. A. Dencausse, X. Violas, H. Feldman, P. Havard, and C. Chambon Pharmacokinetic profile of iobitridol Acta Radiol. Suppl. 400 1995 25 34
7. E.E. Engwerda, C.J. Tack, and B.E. de Galan Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes Diabetes Care 36 11 2013 3436 3441
8. N. Ford, M. Thornton, and D. Holdsworth Fundamental image quality limits for microcomputed tomography in small animals Med. Phys. 30 11 2003 2869 2877
9. A. Frid, and B. Linde Intraregional differences in the absorption of unmodified insulin from the abdominal wall Diabet. Med. 9 3 1992 236 239
10. S. Geman, and D. Geman Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images IEEE Trans. Pattern Anal. Mach. Intell. 6 1984 721 741
11. H. Gin, and H. Hanaire-Broutin Reproducibility and variability in the action of injected insulin Diabetes Metab. 31 1 2005 7 13
12. B. Guerci, and J. Sauvanet Subcutaneous insulin: pharmacokinetic variability and glycemic variability Diabetes Metab. 31 4 2005 (4S7-4S24)
13. J. Gupta, S.S. Park, B. Bondy, E.I. Felner, and M.R. Prausnitz Infusion pressure and pain during microneedle injection into skin of human subjects Biomaterials 32 28 2011 6823 6831
14. G. Hausman, and R.J. Martin Subcutaneous adipose tissue development in Yorkshire (lean) and Ossabaw (obese) pigs J. Anim. Sci. 52 6 1981 1442 1449
15. L. Heinemann Variability of insulin absorption and insulin action Diabetes Technol. Ther. 4 5 2002 673 682
16. P. Hildebrandt, P. Sejrsen, S. Nielsen, K. Birch, and L. Sestoft Diffusion and polymerization determines the insulin absorption from subcutaneous tissue in diabetic patients Scand. J. Clin. Lab. Invest. 45 8 1985 685 690
17. P.L. Hofman, J.G.B. Derraik, T.E. Pinto, S. Tregurtha, A. Faherty, J.M. Peart, P.L. Drury, E. Robinson, R. Tehranchi, M. Donsmark, and et al. Defining the ideal injection techniques when using 5-mm needles in children and adults Diabetes Care 33 9 2010 1940 1944
18. J.P.L. Jockel, P. Roebrock, O.A. Shergold, and C. Huwiler Insulin depot formation in subcutaneous tissue J. Diabetes Sci. Technol. 7 1 2013 227 237
19. B. Karges, B. Boehm, and W. Karges Early hypoglycaemia after accidental intramuscular injection of insulin glargine Diabet. Med. 22 10 2005 1444 1445
20. T. Lauritzen, C. Binder, and O. Faber Importance of insulin absorption, subcutaneous blood flow, and residual beta-cell function in insulin therapy Acta Paediatr. 69 1980 81 84
21. S.Z. Li Markov Random Field Modeling in Image Analysis 2009 Springer
22. Z. Ma, T. Parkner, J. Frystyk, T. Laursen, T. Lauritzen, and J.S. Christiansen A comparison of pharmacokinetics and pharmacodynamics of insulin aspart, biphasic insulin aspart 70, biphasic insulin aspart 50, and human insulin: a randomized, quadruple crossover study Diabetes Technol. Ther. 14 7 2012 589 595
23. J.K. Mader, T. Birngruber, S. Korsatko, S. Deller, G. Köhler, S. Boysen, T. Augustin, S.I. Mautner, F. Sinner, T.R. Pieber, and et al. Enhanced absorption of insulin aspart as the result of a dispersed injection strategy tested in a randomized trial in type 1 diabetic patients Diabetes Care 36 4 2013 780 785
24. S. Ogston-Tuck Subcutaneous injection technique: an evidence-based approach Nurs. Stand. 29 3 2014 53 58
25. A. Pfützner, I. Raz, G. Bitton, D. Klonoff, R. Nagar, N. Hermanns, and T. Haak Improved insulin absorption by means of standardized injection site modulation results in a safer and more efficient prandial insulin treatment. A review of the existing clinical data J. Diabetes Sci. Technol. 9 1 2015 116 122
26. M. Polak, M. Beregszaszi, N. Belarbi, K. Benali, M. Hassan, P. Czernichow, and N. Tubiana-Rufi Subcutaneous or intramuscular injections of insulin in children: Are we injecting where we think we are? Diabetes Care 19 12 1996 1434 1436
27. C.H. Rasmussen, R.M. Røge, Z. Ma, M. Thomsen, R.L. Thorisdottir, J.-W. Chen, E. Mosekilde, and M. Colding-Jørgensen Insulin aspart pharmacokinetics: an assessment of its variability and underlying mechanisms Eur. J. Pharm. Sci. 62 2014 65 75
28. K. Rave, T. Heise, C. Weyer, J. Herrnberger, R. Bender, S. Hirschberger, and L. Heinemann Intramuscular versus subcutaneous injection of soluble and lispro insulin: comparison of metabolic effects in healthy subjects Diabet. Med. 15 9 1998 747 751
29. M. Thomsen, M. Poulsen, M. Bech, A. Velroyen, J. Herzen, F. Beckmann, R. Feidenhans'l, and F. Pfeiffer Visualization of subcutaneous insulin injections by X-ray computed tomography Phys. Med. Biol. 57 2012 7191 7203
30. R.L. Thorisdottir, T. Parkner, J.-W. Chen, N. Ejskjær, and J.S. Christiansen A comparison of pharmacokinetics and pharmacodynamics of biphasic insulin aspart 30, 50, 70 and pure insulin aspart: a randomized, quadruple crossover study Basic Clin. Pharmacol. Toxicol. 104 3 2009 216 221
31. J. Vora, A. Burch, J. Peters, and D. Owens Absorption of radiolabeled soluble insulin in type 1 (insulin-dependent) diabetes: influence of subcutaneous blood flow and anthropometry Diabet. Med. 10 8 1993 736 743