Redefining virulence of bacterial pathogens: Measuring bacterial gene expression and metabolism during infections provides a more comprehensive view of virulence in action

Microbe

Volumn 10, Issue 6, 2015, Pages 239-246

  Mobley, Harry ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84942235130     PISSN: 15587452     EISSN: 15587460     Source Type: Journal    
DOI: 10.1128/microbe.10.239.1     Document Type: Article

References (9)

1. Alteri, C., S. Smith, and H. L. T. Mobley. 2009. Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle. PLoS Pathogens 5:e1000448.
2. Hagan, E. C., A. L. Lloyd, D. A. Rasko, G. J. Faerber, and H. L. T. Mobley. 2010. Escherichia coli global gene expression in urine from women with urinary tract infection. PLoS Pathogens 6:e1001187.
3. Lane, M. C., C. J. Alteri, S. Smith, and H. L. T. Mobley. 2007. Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract. Proc. Natl. Acad. Sci. 104:16669–16674.
4. Lloyd, A. L., D. A. Rasko, and H. L.T. Mobley. 2007. Defıning genomic islands and uropathogen-specifıc genes in uropathogenic E. coli. J. Bacteriol. 189:3532–3546.
5. Snyder, J. A., B. J. Haugen, E. L. Buckles, C. V. Lockatell, D. E. Johnson, M. S. Donnenberg, R. A Welch, and H. L. T. Mobley. 2004. Transcriptome of uropathogenic Escherichia coli during urinary tract infection. Infect. Immun. 72:6373–6381.
6. Spurbeck, R. R., P. C. Dinh Jr., S. T. Walk, A. E. Stapleton, T. M. Hooton, L. K. Nolan, K. S. Kim, J. R. Johnson, and H. L. T. Mobley. 2012. Escherichia coli that carry vat, fyuA, chuA, and yfcV effıciently colonize the urinary tract. Infect. Immun. 80:4115–4122.
7. Subashchandrabose, S., T. H. Hazen, A. R. Brumbaugh, S. D. Himpsl, S. N. Smith, R. D. Ernst, D. A. Rasko, and H. L. T. Mobley. 2014. Hostspecifıc induction of Escherichia coli fıtness genes during human urinary tract infection. Proc. Natl. Acad. Sci. USA 111:18327–18332.
8. Subashchandrabose, S., S. N. Smith, R. R. Spurbeck, M. M. Kole, and H. L. T. Mobley. 2013. Genome-wide detection of fıtness genes in uropathogenic Escherichia coli during systemic infection. PLoS Pathogens 9:e1003788.
9. Vigil, P. D., C. J. Alteri, and H. L.T. Mobley. 2011. Identifıcation of in vivo induced antigens including a RTX family exoprotein required for uropathogenic Escherichia coli virulence. Infect Immun. 79:2335–2344.