From gene to harvest: Insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

Plant Biotechnology Journal

Volumn 13, Issue 8, 2015, Pages 1094-1105

  Sack, Markus ^a   Rademacher, Thomas ^b   Spiegel, Holger ^b   Boes, Alexander ^b   Hellwig, Stephan ^b   Drossard, Juergen ^b   Stoger, Eva ^c   Fischer, Rainer ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

HIV; 2G12; Glasshouse; GMP GACP; Manufacturing licence; Plant made pharmaceuticals; Transgenic tobacco; Upstream process development

Indexed keywords

2G12 MONOCLONAL ANTIBODY; FLUORESCENT PROTEIN 583; MONOCLONAL ANTIBODY; PHOTOPROTEIN;

ANIMAL; BIOMASS; BIOSYNTHESIS; CHO CELL LINE; CRICETULUS; GENE VECTOR; GENETIC ENGINEERING; GENETICS; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; PLANT LEAF; PROCEDURES; TOBACCO; TRANSGENIC PLANT;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOMASS; CHO CELLS; CRICETINAE; CRICETULUS; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; PLANT LEAVES; PLANTS, GENETICALLY MODIFIED; TOBACCO;

EID: 84942196035     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/pbi.12438     Document Type: Review

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