Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up

Pediatric Infectious Disease Journal

Volumn 34, Issue 10, 2015, Pages 1131-1132

  Nenna, Raffaella ^a   Ferrara, Marianna ^a   Nicolai, Ambra ^b   Pierangeli, Alessandra ^b   Scagnolari, Carolina ^a   Papoff, Paola ^b   Antonelli, Guido ^a   Moretti, Corrado ^c   Midulla, Fabio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NONE

Author keywords

Bronchiolitis; Interferon ; Respiratory syncytial virus; Viral load

Indexed keywords

GAMMA INTERFERON; INTERFERON GAMMA1 3; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CAUCASIAN; EOSINOPHIL COUNT; FEMALE; FOLLOW UP; HOSPITALIZED CHILD; HUMAN; INFANT; INFANT DISEASE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECURRENT DISEASE; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RETROSPECTIVE STUDY; VIRAL BRONCHIOLITIS; VIRUS LOAD; WHEEZING; ABNORMAL RESPIRATORY SOUND; BRONCHIOLITIS, VIRAL; GENETICS; HUMAN RESPIRATORY SYNCYTIAL VIRUS; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; VIROLOGY;

BRONCHIOLITIS, VIRAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTERFERON-GAMMA; MALE; RESPIRATORY SOUNDS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RETROSPECTIVE STUDIES; VIRAL LOAD;

EID: 84942068578     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000000825     Document Type: Article

References (12)

1. Bacharier LB, Cohen R, Schweiger T, et al. Determinants of asthma after severe respiratory syncytial virus bronchiolitis. J Allergy Clin Immunol. 2012;130:91-100.e3.
2. Bont L, Ramilo O. The relationship between RSV bronchiolitis and recurrent wheeze: the chicken and the egg. Early Hum Dev. 2011;87 (suppl 1):S51e4.
3. Sigurs N, Bjarnason R, Sigurbergsson F, et al. Asthma and immunoglobu-lin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics. 1995;95:500-505.
4. DeVincenzo J P, El Saleeby CM, Bush AJ. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J Infect Dis. 2005;191:1861-1868.
5. Franz A, Adams O, Willems R, et al. Correlation of viral load of respiratory pathogens and co-infections with disease severity in children hospitalized for lower respiratory tract infection. J Clin Virol. 2010;48:239-245.
6. Midulla F, Scagnolari C, Bonci E, et al. Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants. Arch Dis Child. 2010;95:35-41.
7. Selvaggi C, Pierangeli A, Fabiani M, et al. Interferon lambda 1-3 expression in infants hospitalized for RSV or H RV associated bronchiolitis. J Infect. 2014;68:467-477.
8. Scagnolari C, Midulla F, Selvaggi C, et al. Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. Med Microbiol Immunol. 2012;201:311-317.
9. Midulla F, Pierangeli A, Cangiano G, et al. Rhinovirus bronchiolitis and recurrent wheezing: 1-year follow-up. Eur Respir J. 2012;39:396-402.
10. Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 2003;4:63e8.
11. Jordan WJ, Eskdale J, Boniotto M, et al. Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Genes Immun. 2007;8:13-20.
12. Spann KM, Baturcam E, Schagen J, et al. Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy. Thorax. 2014;69:918-925.