Inhibition of COX-2 and NF- κ B1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium

Planta Medica

Volumn 81, Issue 14, 2015, Pages 1270-1276

  Lajter, Ildikó ^a   Pan, San Po ^b   Nikles, Stefanie ^b   Ortmann, Sabine ^b   Vasas, Andrea ^a   Csupor Löffler, Boglárka ^a   Forgó, Peter ^a   Hohmann, Judit ^a   Bauer, Rudolf ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

5 LOX; Asteraceae; cyclooxygenase 1 and 2; flavonoids; iNOS; lignans; nuclear factor kappa B1; Onopordum acanthium; sesquiterpenes

Indexed keywords

13 OXO 9Z,11E OCTADECADIENOIC ACID; 24 METHYLENECHOLESTEROL; 4BETA,15 DIHYDRO 3 DEHYDROZALUZANIN; 4BETA,15,11BETA,13 TETRAHYDROZALUZANIN C; APIGENIN; ARACHIDONATE 5 LIPOXYGENASE; CHLOROFORM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; FLAVONOID; GAMMA INTERFERON; HISPIDULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUKOTRIENE; LIGNAN; LIPOPOLYSACCHARIDE; LUTEOLIN; MEDIORESINOL; NEPETIN; NITIDANIN DIISOVALERIANATE; NITRIC OXIDE; NUCLEAR FACTOR KAPPA B1; PINORESINOL; QUERCETIN; SESQUITERPENE; SYRINGARESINOL; SYRINGARSINOL; UNCLASSIFIED DRUG; ZALUZANIN; ALOX5 PROTEIN, HUMAN; CYCLOOXYGENASE 2 INHIBITOR; LIPOXYGENASE INHIBITOR; NFKB1 PROTEIN, HUMAN; NOS2 PROTEIN, HUMAN; PLANT EXTRACT; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS1 PROTEIN, HUMAN; PTGS2 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL VIABILITY; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONOPORDUM; ONOPORDUM ACANTHIUM; PLANAR CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; XTT ASSAY; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MEDICINAL PLANT; METABOLISM; PRECLINICAL STUDY; PROCEDURES;

ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; HUMANS; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; NF-KAPPA B P50 SUBUNIT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ONOPORDUM; PLANT EXTRACTS; PLANTS, MEDICINAL;

EID: 84942028293     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0035-1546242     Document Type: Article

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