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Volumn 45, Issue 10, 2015, Pages 1017-1024

Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population

Author keywords

Biomarkers; Lifestyle intervention; Lipids; PCSK9; Physical exercise

Indexed keywords

ADIPONECTIN; ANTILIPEMIC AGENT; APOLIPOPROTEIN B100; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN INSULIN; INSULIN; LIPOCORTIN 2; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; PCSK9 PROTEIN, HUMAN;

EID: 84941992948     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12480     Document Type: Article
Times cited : (36)

References (32)
  • 1
    • 84899795000 scopus 로고    scopus 로고
    • 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129(25 Suppl 2):S76-99.
    • (2014) Circulation , vol.129 , Issue.25 , pp. S76-S99
    • Eckel, R.H.1    Jakicic, J.M.2    Ard, J.D.3    de Jesus, J.M.4    Houston Miller, N.5    Hubbard, V.S.6
  • 2
    • 84897970506 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129(25 Suppl 2):S1-45.
    • (2014) Circulation , vol.129 , Issue.25 , pp. S1-45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 3
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011;32:1769-818.
    • (2011) Eur Heart J , vol.32 , pp. 1769-1818
    • Reiner, Z.1    Catapano, A.L.2    De Backer, G.3    Graham, I.4    Taskinen, M.R.5    Wiklund, O.6
  • 5
    • 0038677039 scopus 로고    scopus 로고
    • Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity)
    • Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 2003;107:3109-16.
    • (2003) Circulation , vol.107 , pp. 3109-3116
    • Thompson, P.D.1    Buchner, D.2    Pina, I.L.3    Balady, G.J.4    Williams, M.A.5    Marcus, B.H.6
  • 6
    • 84890139949 scopus 로고    scopus 로고
    • The influence of regular walking at different times of day on blood lipids and inflammatory markers in sedentary patients with coronary artery disease
    • Lian XQ, Zhao D, Zhu M, Wang ZM, Gao W, Zhao H et al. The influence of regular walking at different times of day on blood lipids and inflammatory markers in sedentary patients with coronary artery disease. Prev Med 2014;58:64-9.
    • (2014) Prev Med , vol.58 , pp. 64-69
    • Lian, X.Q.1    Zhao, D.2    Zhu, M.3    Wang, Z.M.4    Gao, W.5    Zhao, H.6
  • 8
    • 61849163580 scopus 로고    scopus 로고
    • EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries
    • Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur J Cardiovasc Prev Rehabil 2009;16:121-37.
    • (2009) Eur J Cardiovasc Prev Rehabil , vol.16 , pp. 121-137
    • Kotseva, K.1    Wood, D.2    De Backer, G.3    De Bacquer, D.4    Pyorala, K.5    Keil, U.6
  • 9
    • 84862176457 scopus 로고    scopus 로고
    • PCSK9 inhibition: the next statin?
    • Vogel RA. PCSK9 inhibition: the next statin? J Am Coll Cardiol 2012;59:2354-5.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2354-2355
    • Vogel, R.A.1
  • 10
    • 80053432726 scopus 로고    scopus 로고
    • Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture
    • Mayne J, Dewpura T, Raymond A, Bernier L, Cousins M, Ooi TC et al. Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture. Clin Chem 2011;57:1415-23.
    • (2011) Clin Chem , vol.57 , pp. 1415-1423
    • Mayne, J.1    Dewpura, T.2    Raymond, A.3    Bernier, L.4    Cousins, M.5    Ooi, T.C.6
  • 11
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006;354:1264-72.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr, T.H.3    Hobbs, H.H.4
  • 13
    • 84890461947 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
    • 3478-390a
    • Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J 2013;34:3478-90a.
    • (2013) Eur Heart J , vol.34
    • Nordestgaard, B.G.1    Chapman, M.J.2    Humphries, S.E.3    Ginsberg, H.N.4    Masana, L.5    Descamps, O.S.6
  • 15
    • 84903440167 scopus 로고    scopus 로고
    • Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9
    • Ly K, Saavedra YG, Canuel M, Routhier S, Desjardins R, Hamelin J et al. Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9. J Biol Chem 2014;289:17732-46.
    • (2014) J Biol Chem , vol.289 , pp. 17732-17746
    • Ly, K.1    Saavedra, Y.G.2    Canuel, M.3    Routhier, S.4    Desjardins, R.5    Hamelin, J.6
  • 16
    • 84906962536 scopus 로고    scopus 로고
    • Mechanism of action of anti-hypercholesterolemia drugs and their resistance
    • Tiwari V, Khokhar M. Mechanism of action of anti-hypercholesterolemia drugs and their resistance. Eur J Pharmacol 2014;741C:156-70.
    • (2014) Eur J Pharmacol , vol.741C , pp. 156-170
    • Tiwari, V.1    Khokhar, M.2
  • 17
    • 84868206496 scopus 로고    scopus 로고
    • Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
    • Dias CS, Shaywitz AJ, Wasserman SM, Smith BP, Gao B, Stolman DS et al. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J Am Coll Cardiol 2012;60:1888-98.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 1888-1898
    • Dias, C.S.1    Shaywitz, A.J.2    Wasserman, S.M.3    Smith, B.P.4    Gao, B.5    Stolman, D.S.6
  • 18
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial
    • Raal F, Scott R, Somaratne R, Bridges I, Li G, Wasserman SM et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial. Circulation 2012;126:2408-17.
    • (2012) Circulation , vol.126 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3    Bridges, I.4    Li, G.5    Wasserman, S.M.6
  • 19
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial
    • Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 2012;308:2497-506.
    • (2012) JAMA , vol.308 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3    Kim, J.B.4    Xue, A.5    Gebski, V.6
  • 20
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, Knusel B, Liu T, Lei L et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet 2012;380:1995-2006.
    • (2012) Lancet , vol.380 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3    Knusel, B.4    Liu, T.5    Lei, L.6
  • 21
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano RP, Desai NR, Kohli P, Rogers WJ, Somaratne R, Huang F et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet 2012;380:2007-17.
    • (2012) Lancet , vol.380 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3    Rogers, W.J.4    Somaratne, R.5    Huang, F.6
  • 22
    • 84907075451 scopus 로고    scopus 로고
    • PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program
    • Arsenault BJ, Pelletier-Beaumont E, Almeras N, Tremblay A, Poirier P, Bergeron J et al. PCSK9 levels in abdominally obese men: association with cardiometabolic risk profile and effects of a one-year lifestyle modification program. Atherosclerosis 2014;236:321-6.
    • (2014) Atherosclerosis , vol.236 , pp. 321-326
    • Arsenault, B.J.1    Pelletier-Beaumont, E.2    Almeras, N.3    Tremblay, A.4    Poirier, P.5    Bergeron, J.6
  • 24
    • 84865260994 scopus 로고    scopus 로고
    • Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study
    • Hamer M, Sabia S, Batty GD, Shipley MJ, Tabak AG, Singh-Manoux A et al. Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study. Circulation 2012;126:928-33.
    • (2012) Circulation , vol.126 , pp. 928-933
    • Hamer, M.1    Sabia, S.2    Batty, G.D.3    Shipley, M.J.4    Tabak, A.G.5    Singh-Manoux, A.6
  • 25
    • 84921716757 scopus 로고    scopus 로고
    • Effect of physical activity level on biomarkers of inflammation and insulin resistance over 5 years in outpatients with coronary heart disease (from the Heart and Soul Study)
    • Jarvie JL, Whooley MA, Regan MC, Sin NL, Cohen BE. Effect of physical activity level on biomarkers of inflammation and insulin resistance over 5 years in outpatients with coronary heart disease (from the Heart and Soul Study). Am J Cardiol 2014;114:1192-7.
    • (2014) Am J Cardiol , vol.114 , pp. 1192-1197
    • Jarvie, J.L.1    Whooley, M.A.2    Regan, M.C.3    Sin, N.L.4    Cohen, B.E.5
  • 26
    • 3242877433 scopus 로고    scopus 로고
    • Annexins-unique membrane binding proteins with diverse functions
    • Rescher U, Gerke V. Annexins-unique membrane binding proteins with diverse functions. J Cell Sci 2004;117(Pt 13):2631-9.
    • (2004) J Cell Sci , vol.117 , pp. 2631-2639
    • Rescher, U.1    Gerke, V.2
  • 27
    • 57649129016 scopus 로고    scopus 로고
    • Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
    • Mayer G, Poirier S, Seidah NG. Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem 2008;283:31791-801.
    • (2008) J Biol Chem , vol.283 , pp. 31791-31801
    • Mayer, G.1    Poirier, S.2    Seidah, N.G.3
  • 28
    • 84864413267 scopus 로고    scopus 로고
    • Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation
    • Seidah NG, Poirier S, Denis M, Parker R, Miao B, Mapelli C et al. Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PLoS ONE 2012;7:e41865.
    • (2012) PLoS ONE , vol.7 , pp. e41865
    • Seidah, N.G.1    Poirier, S.2    Denis, M.3    Parker, R.4    Miao, B.5    Mapelli, C.6
  • 29
    • 84905752955 scopus 로고    scopus 로고
    • The effect of insulin on circulating PCSK9 in postmenopausal obese women
    • Awan Z, Dubuc G, Faraj M, Dufour R, Seidah NG, Davignon J et al. The effect of insulin on circulating PCSK9 in postmenopausal obese women. Clin Biochem 2014;47:1033-9.
    • (2014) Clin Biochem , vol.47 , pp. 1033-1039
    • Awan, Z.1    Dubuc, G.2    Faraj, M.3    Dufour, R.4    Seidah, N.G.5    Davignon, J.6
  • 30
    • 84856764290 scopus 로고    scopus 로고
    • Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome
    • Richard C, Couture P, Desroches S, Benjannet S, Seidah NG, Lichtenstein AH et al. Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome. Br J Nutr 2012;107:705-11.
    • (2012) Br J Nutr , vol.107 , pp. 705-711
    • Richard, C.1    Couture, P.2    Desroches, S.3    Benjannet, S.4    Seidah, N.G.5    Lichtenstein, A.H.6
  • 31
    • 84875055214 scopus 로고    scopus 로고
    • PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells
    • Levy E, Ben Djoudi Ouadda A, Spahis S, Sane AT, Garofalo C, Grenier E et al. PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells. Atherosclerosis 2013;227:297-306.
    • (2013) Atherosclerosis , vol.227 , pp. 297-306
    • Levy, E.1    Ben Djoudi Ouadda, A.2    Spahis, S.3    Sane, A.T.4    Garofalo, C.5    Grenier, E.6
  • 32
    • 84905101303 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms
    • Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I et al. Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms. Circulation 2014;130:431-41.
    • (2014) Circulation , vol.130 , pp. 431-441
    • Rashid, S.1    Tavori, H.2    Brown, P.E.3    Linton, M.F.4    He, J.5    Giunzioni, I.6


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