Hyperphosphatemia is an independent risk factor for mortality in critically Ill patients: Results from a cross-sectional study

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Haider, Dominik G ^a   Lindner, Gregor ^a   Wolzt, Michael ^b   Ahmad, Sufian S ^a   Sauter, Thomas ^a   Leichtle, Alexander Benedikt ^a   Fiedler, Georg Martin ^a   Fuhrmann, Valentin ^c   Exadaktylos, Aristomenis K ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE;

ADULT; AGE; ARTICLE; CLINICAL ASSESSMENT; COHORT ANALYSIS; CONTROLLED STUDY; CRITICALLY ILL PATIENT; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DIURETIC THERAPY; EMERGENCY WARD; FEMALE; GLOMERULUS FILTRATION RATE; HOSPITAL ADMISSION; HUMAN; HYPERPHOSPHATEMIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHOSPHATE BLOOD LEVEL; RETROSPECTIVE STUDY; RISK FACTOR; SWITZERLAND; AGED; COMPLICATION; CRITICAL ILLNESS; HOSPITAL MORTALITY; HOSPITALIZATION; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODEL;

ADULT; AGED; CRITICAL ILLNESS; CROSS-SECTIONAL STUDIES; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; HYPERPHOSPHATEMIA; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84941953218     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133426     Document Type: Article

References (28)

1. Hruska KA, Mathew S, Lund R, Qiu P, Pratt R. Hyperphosphatemia of chronic kidney disease. Kidney Int 2008; 74:148-157. doi: 10.1038/ki.2008.130 PMID: 18449174
2. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15:2208-2218. PMID: 15284307
3. Slinin Y, Foley RN, Collins AJ. Calcium, phosphorus, parathyroid hormone, and cardiovascular disease in hemodialysis patients: the USRDS waves 1, 3, and 4 study. J Am Soc Nephrol 2005; 16:1788-1793. PMID: 15814832
4. Kestenbaum B, Sampson JN, Rudser KD, Patterson DJ, Seliger SL, Young B, et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16:520-528. PMID: 15615819
5. Voormolen N, Noordzij M, Grootendorst DC, Beetz I, Sijpkens YW, van Manen JG, et al. High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients. Nephrol Dial Transplant 2007; 22:2909-2916. PMID: 17517792
6. Foley RN, Collins AJ, Ishani A, Kalra PA. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2008; 156:556-563. doi: 10.1016/j.ahj.2008.05.016 PMID: 18760141
7. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA. Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 2009; 20:397-404. doi: 10.1681/ASN. 2008020141 PMID: 18987306
8. Ellam TJ, Chico TJ. Phosphate: the new cholesterol? The role of the phosphate axis in non-uremic vascular disease. Atherosclerosis 2012; 220:310-318. doi: 10.1016/j.atherosclerosis.2011.09.002 PMID: 21962238
9. Betro MG, Pain RW. Hypophosphataemia and hyperphosphataemia in a hospital population. Br Med J. 1972; 1:273-276. PMID: 5008477
10. Larsson L, Rebel K, Sorbo B. Severe hypophosphatemia: a hospital survey. Acta Med Scand.1983; 214:221-223. PMID: 6660029
11. King AL, Sica DA, Miller G, Pierpaoli S. Severe hypophosphatemia in a general hospital population. South Med J. 1987; 80:831-835. PMID: 3603104
12. Camp MA, Allon M. Severe hypophosphatemia in hospitalized patients. Miner Electrolyte Metab.1990; 16:365-368. PMID: 2089250
13. Hoffmann M, Zemlin AE, Meyer WP, Erasmus RT. Hypophosphataemia at a large academic hospital in South Africa. J Clin Pathol. 2008; 61:1104-1107. doi: 10.1136/jcp.2007.054940 PMID: 18820097
14. Cohen J, Kogan A, Sahar G, Lev S, Vidne B, Singer P. Hypophosphatemia following open heart surgery: incidence and consequences. Eur J Cardiothorac Surg. 2004; 26:306-310. PMID: 15296888
15. Goldstein J, Vincent JL, Leclerc JL, Vanderhoeft P, Kahn RJ. Hypophosphatemia after cardiothoracic surgery. Intensive Care Med. 1985; 11:144-148. PMID: 3998274
16. Buell JF, Berger AC, Plotkin JS, Kuo PC, Johnson LB. The clinical implications of hypophosphatemia following major hepatic resection or cryosurgery. Arch Surg. 1998; 133:757-761. PMID: 9688005
17. Sullivan C, Sayre SS, Leon JB, Machekano R, Love TE, Porter D, et al. Effect of food additives on hyperphosphatemia among patients with end-stage renal disease: a randomized controlled trial. JAMA. 2009; 301:629-635. doi: 10.1001/jama.2009.96 PMID: 19211470
18. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA. Serum phosphorus levels associate with coronary atherosclerosis in young adults. JASN.2009; 20:397-404. doi: 10.1681/ASN.2008020141 PMID: 18987306
19. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB Sr, Gaziano JM, Vasan RS. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med. 2007; 167:879-885. PMID: 17502528
20. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G; Cholesterol And Recurrent Events Trial Investigators. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation. 2005; 112:2627-2633. PMID: 16246962
21. Shor R, Halabe A, Rishver S, Tilis Y, Matas Z, Fux A, et al. Severe hypophosphatemia in sepsis as a mortality predictor. Ann Clin Lab Sci. 2006; 36:67-72. PMID: 16501239
22. Zazzo JF, Troche G, Ruel P, Maintenant J. High incidence of hypophosphatemia in surgical intensive care patients: efficacy of phosphorus therapy on myocardial function. Intensive Care Med.1995; 21:826-831. PMID: 8557871
23. Wilson HK, Keuer SP, Lea AS, Boyd AE, Eknoyan G. Phosphate therapy in diabetic ketoacidosis.Arch Intern Med. 1982; 142:517-520. PMID: 6802095
24. Fisher J, Magid N, Kallman C, Fanucchi M, Klein L, McCarthy D, et al. Respiratory illness and hypophosphatemia. Chest. 1983; 83:504-508. PMID: 6825484
25. Woodhead MA, Macfarlane JT. Legionnaires' disease: a review of 79 community acquired cases in Nottingham. Thorax. 1986; 41:635-640. PMID: 3787545
26. Sankaran RT, Mattana J, Pollack S, Bhat P, Ahuja T, Patel A, et al. Laboratory abnormalities in patients with bacterial pneumonia. Chest. 1997; 111:595-600. PMID: 9118693
27. Vaidyanathan D, Venkatesan S, Ramadesikan VK. Serum phosphate in acute myocardial infarction. Indian J Physiol Pharmacol. 2000; 44:225-228. PMID: 10846641
28. Chung PY, Sitrin MD, Te HS. Serum phosphorus levels predict clinical outcome in fulminant hepatic failure. Liver Transpl. 2003; 9:248-253. PMID: 12619021