Development of novel tools for the in vitro investigation of drug-induced liver injury

Expert Opinion on Drug Metabolism and Toxicology

Volumn 11, Issue 10, 2015, Pages 1523-1537

  Jiang, Jian ^a   Wolters, Jarno E J ^a   Van Breda, Simone G ^a   Kleinjans, Jos C ^a   De Kok, Theo M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

omics technologies; 3D culture; drug induced liver injury; multicellular hepatospheres; primary hepatocytes; sequencing technologies; toxicogenomics

Indexed keywords

UNTRANSLATED RNA;

CELL ADHESION; CELL DEDIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CELL SUSPENSION; COCULTURE; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENOMICS; HEPG2 CELL LINE; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER SLICE; LIVER TOXICITY; METABOLOMICS; MULTICELLULAR SPHEROID; NONHUMAN; PROTEOMICS; REVIEW; RNA SEQUENCE; STEM CELL; TOXIC HEPATITIS; TRANSCRIPTOMICS; ANIMAL; ANIMAL TESTING ALTERNATIVE; BIOLOGICAL MODEL; DRUG-INDUCED LIVER INJURY; PROCEDURES; SPECIES DIFFERENCE; TOXICOGENETICS; TOXICOLOGY;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DRUG-INDUCED LIVER INJURY; HUMANS; MODELS, BIOLOGICAL; SPECIES SPECIFICITY; TOXICOGENETICS; TOXICOLOGY;

EID: 84941946184     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2015.1065814     Document Type: Review

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