Is Statin Use Associated with Tendon Rupture? A Population-Based Retrospective Cohort Analysis

American Journal of Therapeutics

Volumn 22, Issue 5, 2015, Pages 377-381

  Contractor, Tahmeed ^a   Beri, Abhimanyu ^b   Gardiner, Joseph C ^c   Tang, Xiaoqin ^d   Dwamena, Francesca C ^c  

^a Valley Health   (United States)

^b KAISER PERMANENTE   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d GEISINGER HEALTH SYSTEM   (United States)

Author keywords

3 hydroxy 3 methylglutaryl Coa reductase inhibitors; adverse drug reaction; tendon rupture

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

ADULT; AGE DISTRIBUTION; ARTICLE; CHRONIC KIDNEY DISEASE; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GOUT; HUMAN; HYPERPARATHYROIDISM; ICD-9; INCIDENCE; INFLAMMATION; LUPUS ERYTHEMATOSUS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; RISK FACTOR; SEX DIFFERENCE; TENDON RUPTURE; INSURANCE; RETROSPECTIVE STUDY; RUPTURE; TENDON INJURIES;

ADULT; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSURANCE CLAIM REVIEW; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; RUPTURE; TENDON INJURIES;

EID: 84941880893     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0000000000000039     Document Type: Article

References (23)

1. Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA. 1998;279:1615-1622.
2. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994;344:1383-1389.
3. Centers for Disease Control and Prevention. Health, United States, 2010. Available at: http://www.cdc.gov/nchs/data/hus/2010/fig17pdf. Accessed November 12, 2012.
4. Marie I, Delafenetre H, Massy N, et al. Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990-2005 and review of the literature. Arthritis Rheum. 2008;59:367-372.
5. Pullatt RC, Gadarla MR, Karas RH, et al. Tendon rupture associated with simvastatin/ezetimibe therapy. Am J Cardiol. 2007;100:152-153.
6. Chazerain P, Hayem G, Hamza S, et al. Four cases of tendinopathy in patients on statin therapy. Joint Bone Spine. 2001;68:430-433.
7. Schonbeck U, Libby P. Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents? Circulation. 2004;109:II18-II26.
8. Turner NA, O'Regan DJ, Ball SG, et al. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J. 2005;19:804-806.
9. Clegg PD, Strassburg S, Smith RK. Cell phenotypic variation in normal and damaged tendons. Int J Exp Pathol. 2007;88:227-235.
10. Riley G. Symposium: tendon and ligament remodelling and regeneration. Int J Exp Pathol. 2007;88:215-216.
11. Beri A, Dwamena FC, Dwamena BA. Association between statin therapy and tendon rupture: a casecontrol study. J Cardiovasc Pharmacol. 2009;53:401-404.
12. Brookhart MA, Patrick AR, Dormuth C, et al. Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol. 2007;166:348-354.
13. Van Der Linden PD, Van Puijenbroek EP, Feenstra J, et al. Tendon disorders attributed to fluoroquinolones: a study on 42 spontaneous reports in the period 1988 to 1998. Arthritis Rheum. 2001;45:235-239.
14. Haines JF. Bilateral rupture of the Achilles tendon in patients on steroid therapy. Ann Rheum Dis. 1983;42: 652-654.
15. Peiró A, Ferrandis R, Garcia L, et al Rupture of the patellar tendon in rheumatoid arthritis: a case report. Acta Orthop Scand. 1975;46:700-703.
16. Furie RA, Chartash EK. Tendon rupture in systemic lupus erythematosus. Semin Arthritis Rheum. 1988;18: 127-133.
17. Mahoney PG, James PD, Howell CJ, et al. Spontaneous rupture of the Achilles tendon in a patient with gout. Ann Rheum Dis. 1981;40:416-418.
18. Shah MK. Simultaneous bilateral quadriceps tendon rupture in renal patients. Clin Nephrol. 2002;58:118-121.
19. Burner TW, Rosenthal AK. Diabetes and rheumatic diseases. Curr Opin Rheumatol. 2009;21:50-54.
20. Barasch E, Lombardi LJ, Arena L, et al. MRI visualization of bilateral quadriceps tendon rupture in a patient with secondary hyperparathyroidism: implications for diagnosis and therapy. Comput Med Imaging Graph. 1989;13:407-410.
21. Meade TD. FDA correctly identifies risks from statins. [The Morning Call website]. Available at http://articles.mcall. com/2012-03-10/opinion/mc-statin-side-effects-meadeyv-20120310-1-statins-crestor-people-without-heart-disease. Accessed November 12, 2013.
22. Doll R, Peto R, Wheatley K, et al. Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ. 1994;309:901-911.
23. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;111: 383-390.