Silent cerebral infarcts in very young children with sickle cell anaemia are associated with a higher risk of stroke

British Journal of Haematology

Volumn 171, Issue 1, 2015, Pages 120-129

  Cancio, Maria I ^a   Helton, Kathleen J ^a   Schreiber, Jane E ^a   Smeltzer, Matthew P ^a,b   Kang, Guolian ^a   Wang, Winfred C ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF MEMPHIS   (United States)

Author keywords

Magnetic resonance imaging; Sickle cell anaemia; Silent cerebral infarction; Stroke

Indexed keywords

ACADEMIC FAILURE; AGE; ANEMIA; ARTICLE; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; CHILD; CLINICAL ARTICLE; COGNITIVE DEFECT; COHORT ANALYSIS; DISEASE COURSE; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFANT; LONGITUDINAL STUDY; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SICKLE CELL ANEMIA; SILENT CEREBRAL INFARCTION; TRANSIENT ISCHEMIC ATTACK; ANEMIA, SICKLE CELL; BRAIN ANGIOGRAPHY; CLINICAL TRIAL; COMPLICATION; RADIOGRAPHY; STROKE;

ANEMIA, SICKLE CELL; BRAIN INFARCTION; CEREBRAL ANGIOGRAPHY; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; STROKE;

EID: 84941745403     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13525     Document Type: Article

References (36)

1. Adams, R.J., McKie, V.C., Brambilla, D., Carl, E., Gallagher, D., Nichols, F.T., Roach, S., Abboud, M., Berman, B., Driscoll, C., Files, B., Hsu, L., Hurlet, A., Miller, S., Olivieri, N., Pegelow, C., Scher, C., Vichinsky, E., Wang, W., Woods, G., Kutlar, A., Wright, E., Hagner, S., Tighe, F., Lewin, J., Cure, J., Zimmerman, R.A., Waclawiw, M.A. (1998) Stroke prevention trial in sickle cell anemia. Controlled Clinical Trials, 19, 110-129.
2. Armstrong, F.D., Thompson, Jr, R.J., Wang, W., Zimmerman, R., Pegelow, C.H., Miller, S., Moser, F., Bello, J., Hurtig, A. & Vass, K. (1996) Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease. Neuropsychology Committee of the Cooperative Study of Sickle Cell Disease. Pediatrics, 97, 864-870.
3. Bayley, N. (1993) Bayley Scales of Infant Development, 2nd edn. The Psychological Corporation, San Antonio, TX.
4. Bernaudin, F., Verlhac, S., Arnaud, C., Kamdem, A., Chevret, S., Hau, I., Coic, L., Leveille, E., Lemarchand, E., Lesprit, E., Abadie, I., Medejel, N., Madhi, F., Lemerle, S., Biscardi, S., Bardakdjian, J., Galacteros, F., Torres, M., Kuentz, M., Ferry, C., Socie, G., Reinert, P. & Delacourt, C. (2011) Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort. Blood, 117, 1130-1140.
5. Broderick, J., Talbot, G.T., Prenger, E., Leach, A. & Brott, T. (1993) Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage. Journal of Child Neurology, 8, 250-255.
6. Casella, J.F., King, A.A., Barton, B., White, D.A., Noetzel, M.J., Ichord, R.N., Terrill, C., Hirtz, D., McKinstry, R.C., Strouse, J.J., Howard, T.H., Coates, T.D., Minniti, C.P., Campbell, A.D., Vendt, B.A., Lehmann, H. & Debaun, M.R. (2010) Design of the silent cerebral infarct transfusion (SIT) trial. Pediatric Hematology and Oncology, 27, 69-89.
7. DeBaun, M.R., Sarnaik, S.A., Rodeghier, M.J., Minniti, C.P., Howard, T.H., Iyer, R.V., Inusa, B., Telfer, P.T., Kirby-Allen, M., Quinn, C.T., Bernaudin, F., Airewele, G., Woods, G.M., Panepinto, J.A., Fuh, B., Kwiatkowski, J.K., King, A.A., Rhodes, M.M., Thompson, A.A., Heiny, M.E., Redding-Lallinger, R.C., Kirkham, F.J., Sabio, H., Gonzalez, C.E., Saccente, S.L., Kalinyak, K.A., Strouse, J.J., Fixler, J.M., Gordon, M.O., Miller, J.P., Noetzel, M.J., Ichord, R.N. & Casella, J.F. (2012) Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood, 119, 3684-3690.
8. DeBaun, M.R., Gordon, M., McKinstry, R.C., Noetzel, M.J., White, D.A., Sarnaik, S.A., Meier, E.R., Howard, T.H., Majumdar, S., Inusa, B.P., Telfer, P.T., Kirby-Allen, M., McCavit, T.L., Kamdem, A., Airewele, G., Woods, G.M., Berman, B., Panepinto, J.A., Fuh, B.R., Kwiatkowski, J.L., King, A.A., Fixler, J.M., Rhodes, M.M., Thompson, A.A., Heiny, M.E., Redding-Lallinger, R.C., Kirkham, F.J., Dixon, N., Gonzalez, C.E., Kalinyak, K.A., Quinn, C.T., Strouse, J.J., Miller, J.P., Lehmann, H., Kraut, M.A., Ball, Jr, W.S., Hirtz, D. & Casella, J.F. (2014) Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. The New England Journal of Medicine, 371, 699-710.
9. Easton, J.D., Saver, J.L., Albers, G.W., Alberts, M.J., Chaturvedi, S., Feldmann, E., Hatsukami, T.S., Higashida, R.T., Johnston, S.C., Kidwell, C.S., Lutsep, H.L., Miller, E. & Sacco, R.L. (2009) Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. Stroke; A Journal of Cerebral Circulation, 40, 2276-2293.
10. Elliot, C.D. (1990) Differential Ability Scales. The Psychological Corporation, San Antonio, TX.
11. Helton, K.J., Adams, R.J., Kesler, K.L., Lockhart, A., Aygun, B., Driscoll, C., Heeney, M.M., Jackson, S.M., Krishnamurti, L., Miller, S.T., Sarnaik, S.A., Schultz, W.H. & Ware, R.E. (2014) Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial. Blood, 124, 891-898.
12. Hulbert, M.L., McKinstry, R.C., Lacey, J.L., Moran, C.J., Panepinto, J.A., Thompson, A.A., Sarnaik, S.A., Woods, G.M., Casella, J.F., Inusa, B., Howard, J., Kirkham, F.J., Anie, K.A., Mullin, J.E., Ichord, R., Noetzel, M., Yan, Y., Rodeghier, M. & Debaun, M.R. (2011) Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood, 117, 772-779.
13. King, A.A., Strouse, J.J., Rodeghier, M.J., Compas, B.E., Casella, J.F., McKinstry, R.C., Noetzel, M.J., Quinn, C.T., Ichord, R., Dowling, M.M., Miller, J.P. & Debaun, M.R. (2014) Parent education and biologic factors influence on cognition in sickle cell anemia. American Journal of Hematology, 89, 162-167.
14. Kwiatkowski, J.L., Zimmerman, R.A., Pollock, A.N., Seto, W., Smith-Whitley, K., Shults, J., Blackwood-Chirchir, A. & Ohene-Frempong, K. (2009) Silent infarcts in young children with sickle cell disease. British Journal of Haematology, 146, 300-305.
15. McCarthy, D.A. (1972) McCarthy Scales of Children's Abilities. The Psychological Corporation, New York, NY.
16. McCarville, M.B., Goodin, G.S., Fortner, G., Li, C.S., Smeltzer, M.P., Adams, R. & Wang, W. (2008) Evaluation of a comprehensive transcranial doppler screening program for children with sickle cell anemia. Pediatric Blood & Cancer, 50, 818-821.
17. Miller, S.T., Macklin, E.A., Pegelow, C.H., Kinney, T.R., Sleeper, L.A., Bello, J.A., DeWitt, L.D., Gallagher, D.M., Guarini, L., Moser, F.G., Ohene-Frempong, K., Sanchez, N., Vichinsky, E.P., Wang, W.C., Wethers, D.L., Younkin, D.P., Zimmerman, R.A. & DeBaun, M.R. (2001) Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease. Journal of Pediatrics, 139, 385-390.
18. Mohr, J.P. (2014) History of transient ischemic attack definition. Frontiers of Neurology and Neuroscience, 33, 1-10.
19. Moser, F.G., Miller, S.T., Bello, J.A., Pegelow, C.H., Zimmerman, R.A., Wang, W.C., Ohene-Frempong, K., Schwartz, A., Vichinsky, E.P., Gallagher, D. & Kinney, T.R. (1996) The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease. AJNR. American Journal of Neuroradiology, 17, 965-972.
20. Ohene-Frempong, K., Weiner, S.J., Sleeper, L.A., Miller, S.T., Embury, S., Moohr, J.W., Wethers, D.L., Pegelow, C.H. & Gill, F.M. (1998) Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood, 91, 288-294.
21. Pegelow, C.H., Macklin, E.A., Moser, F.G., Wang, W.C., Bello, J.A., Miller, S.T., Vichinsky, E.P., DeBaun, M.R., Guarini, L., Zimmerman, R.A., Younkin, D.P., Gallagher, D.M. & Kinney, T.R. (2002) Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease. Blood, 99, 3014-3018.
22. Schatz, J., Brown, R.T., Pascual, J.M., Hsu, L. & DeBaun, M.R. (2001) Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Neurology, 56, 1109-1111.
23. Silva, G.S., Vicari, P., Figueiredo, M.S., Carrete, Jr, H., Idagawa, M.H. & Massaro, A.R. (2009) Brain magnetic resonance imaging abnormalities in adult patients with sickle cell disease: correlation with transcranial Doppler findings. Stroke; A Journal of Cerebral Circulation, 40, 2408-2412.
24. Steen, R.G., Miles, M.A., Helton, K.J., Strawn, S., Wang, W., Xiong, X. & Mulhern, R.K. (2003a) Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit. AJNR. American Journal of Neuroradiology, 24, 382-389.
25. Steen, R.G., Emudianughe, T., Hankins, G.M., Wynn, L.W., Wang, W.C., Xiong, X. & Helton, K.J. (2003b) Brain imaging findings in pediatric patients with sickle cell disease. Radiology, 228, 216-225.
26. Steinberg, M.H. (2005) Predicting clinical severity in sickle cell anaemia. British Journal of Haematology, 129, 465-481.
27. United States Department of Education - Special Education and Rehabilitative Services. (2004) The Rehabilitation Act 2004.
28. Wang, W.C., Langston, J.W., Steen, R.G., Wynn, L.W., Mulhern, R.K., Wilimas, J.A., Kim, F.M. & Figueroa, R.E. (1998) Abnormalities of the central nervous system in very young children with sickle cell anemia. Journal of Pediatrics, 132, 994-998.
29. Wang, W.C., Pavlakis, S.G., Helton, K.J., McKinstry, R.C., Casella, J.F., Adams, R.J. & Rees, R.C. (2008) MRI abnormalities of the brain in one-year-old children with sickle cell anemia. Pediatric Blood & Cancer, 51, 643-646.
30. Wechsler, D. (1989) Wechsler Preschool and Primary Scale of Intelligence-Revised. The Psychological Corporation, San Antonio, TX.
31. Wechsler, D. (1991) Wechsler Intelligence Scale for Children, 3rd edn. The Psychological Corporation, San Antonio, TX.
32. Wechsler, D. (1999) Wechsler Abbreviated Scale of Intelligence. The Psychological Corporation, San Antonio, TX.
33. Wechsler, D. (2003) Wechsler Intelligence Scale for Children, 4th edn. Pearson Assessments, San Antonio, TX.
34. Wechsler, D. (2008) Wechsler Adult Intelligence Scale, 4th edn. Pearson Assessments, San Antonio, TX.
35. Wechsler, D. (2011) Wechsler Abbreviated Scale of Intelligence, 2nd edn. Pearson Assessments, San Antonio, TX.
36. Woodcock, R.W., McGrew, K.S. & Mather, N. (2001) Woodcock-Johnson III Tests of Cognitive Abilities. Riverside, Itasca, IL.