Dissolution study and thermal analysis of fenofibrate–Pluronic F127 solid dispersions

Journal of Thermal Analysis and Calorimetry

Volumn 125, Issue 2, 2016, Pages 751-757

  Karolewicz, Bożena ^a   Gajda, Maciej ^a   Pluta, Janusz ^a   Górniak, Agata ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

DSC studies; Fenofibrate; Intrinsic dissolution rate; Pluronic F127; Solid dispersion; XRPD

Indexed keywords

BIOCHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; EUTECTICS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LANDFORMS; THERMOANALYSIS; WETLANDS; X RAY POWDER DIFFRACTION;

DISSOLUTION RATES; DSC STUDIES; FENOFIBRATE; PLURONIC F-127; SOLID DISPERSION; XRPD;

DISPERSIONS;

EID: 84941695966     PISSN: 13886150     EISSN: 15882926     Source Type: Journal    
DOI: 10.1007/s10973-015-5013-2     Document Type: Article

References (22)

1. Granero GE, Ramachandran C, Amidon GL. Dissolution and solubility behavior of fenofibrate in sodium lauryl sulfate solutions. Drug Dev Ind Pharm. 2005;31:917–22.
2. Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman’s the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill Companies; 2006.
3. Law D, Wang W, Schmitt EA, Qiu Y, Krill SL, Fort JJ. Properties of rapidly dissolving eutectic mixtures of poly(ethylene glycol) and fenofibrate: the eutectic microstructure. J Pharm Sci. 2003;92:505–15.
4. He H, Yang R, Tang X. In vitro and in vivo evaluation of fenofibrate solid dispersion prepared by hot-melt extrusion. Drug Dev Ind Pharm. 2010;36:681–7.
5. Kataria MK, Bhandari A. Solubility and dissolution enhancement: technologies and research emerged. J Biol Sci Opin. 2013;1:105–16.
6. Vogt M, Kunath K, Dressman JB. Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations. Eur J Pharm Biopharm. 2008;68:283–8.
7. Bhise SD. Ternary solid dispersions of fenofibrate with poloxamer 188 and TPGS for enhancement of solubility and bioavailability. Int J Res Pharm Biomed Sci. 2011;2:583–95.
8. Yousaf AM, Kim DW, Kim JO, Chang PS, Baek HH, Lim SJ, Cho KH, Yong CS, Choi HG. Characterization of physicochemical properties of spray-dried solid dispersions loaded with unmodified crystalline fenofibrate. Curr Pharm Anal. 2015;11:139–44.
9. Babu AM, Rao BP, Sudhakar P. Development and characterization of novel self-microemulsion drug delivery system of low solubility drug “fenofibrate” for improved oral bioavailability. Int J Biol Pharm Res. 2012;3:616–23.
10. Ajmera A, Deshpande S, Kharadi S, Rathod K, Patel K, Patel P. Dissolution rate enhancement of atorvastatin, fenofibrate and ezetimibe by inclusion complex with β-cyclodextrin. Asian J Pharm Clin Res. 2012;4:73–6.
11. Jamzad S, Fassihi R. Role of Surfactant and pH on dissolution properties of fenofibrate and glipizide—a technical note. AAPS Pharm Sci Tech. 2006;7:E33.
12. Yadav VB, Yadav AV. Enhancement of solubility and dissolution rate of BCS class II pharmaceuticals by nonaquious granulation technique. Int J Pharm Res Dev. 2010;1:1–8.
13. Yadav VB, Yadav AV. Enhancement of solubility and dissolution rate of fenofibrate by melt granulation technique. Int J Pharm Tech Res. 2009;1:256–63.
14. Kalidova A, Fischbach M, Kleinebudde P. Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion. Int J Pharm. 2012;429:58–68.
15. Bonthagarala B, Nama S, Nuthakki S, Kiran KV, Pasumarthi P. Enhancement of dissolution rate of fenofibrate by using various solid dispersion techniques. World J Pharm Pharm Sci. 2014;3:914–32.
16. Swati S, Mohan MV. Formulation, characterization, in vitro and in vivo evaluation of fenofibrate solid dispersions. Adv Sci Eng Med. 2014;6:625–36.
17. Tejas P, Patel LD, Tamir P, Sunil M, Tushar P. Enhancement of dissolution of fenofibrate by solid dispersion technique. Int J Res Pharm Sci. 2010;2:127–32.
18. Tejas P, Patel LD, Adeshara SP, Timir P, Sunil M, Tushar P. Dissolution enhancement of fenofibrate by solid dispersion technique. Curr Pharm Res. 2011;1:127–34.
19. Islam MdS, Mehjabeen K, Mustary I, Khan F, Jalil R. Improvementof dissolution of ibuprofen and fenofibrate by poloxamer based solid dispersion. Bangladesh Pharm J. 2010;13:54–9.
20. Irwan AW, Berania JE, Liu X. A comparative study on the effects of amphiphilic and hydrophilic polymers on the release profiles of poorly water-soluble drug. Pharm Dev Technol. 2014. doi:10.3109/10837450.2014.991877.
21. Rycerz L. Practical remarks concerning phase diagrams determination on the basis of differential scanning calorimetry measurements. J Therm Anal Calorim. 2013;113:231–8.
22. Kaplan SA. Biopharmaceutical considerations in drug formation design and evaluation. Drug Metab Rev. 1972;1:15–34.