Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 28, 2015, Pages 8533-8542

  Frej, Cecilia ^a   Andersson, Anders ^a   Larsson, Benny ^b   Guo, Li Jun ^a   Norström, Eva ^a   Happonen, Kaisa E ^a   Dahlbäck, Björn ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apolipoprotein; Liquid chromatography; Mass spectrometry

Indexed keywords

ALKANOLAMINES; BIOLOGICAL MATERIALS; COAGULATION; GEL PERMEATION CHROMATOGRAPHY; LIPOPROTEINS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLATELETS; SPHINGOSINES;

ACCURACY AND PRECISION; APOLIPOPROTEINS; EXTRACTION PROCEDURE; GEL-FILTRATION CHROMATOGRAPHY; HEALTHY INDIVIDUALS; MULTIPLE CELLULAR FUNCTIONS; PLATELET ACTIVATION; SPHINGOSINE 1 PHOSPHATES;

IMPORTANCE SAMPLING;

APOLIPOPROTEIN; APOM PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN; LIPOCALIN; LYSOPHOSPHOLIPID; PROTEIN BINDING; SERUM ALBUMIN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANALOGS AND DERIVATIVES; BIOSYNTHESIS; BLOOD; BLOOD CLOTTING; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; METABOLISM; PHYSIOLOGY; PLASMA; PROCEDURES; SERUM; STANDARDS; TANDEM MASS SPECTROMETRY; THROMBOCYTE; THROMBOCYTE ACTIVATION; VALIDATION STUDY;

APOLIPOPROTEINS; BLOOD COAGULATION; BLOOD PLATELETS; CHROMATOGRAPHY, LIQUID; HUMANS; LIPOCALINS; LIPOPROTEINS, HDL; LIQUID-LIQUID EXTRACTION; LYSOPHOSPHOLIPIDS; PLASMA; PLATELET ACTIVATION; PROTEIN BINDING; SERUM; SERUM ALBUMIN; SPHINGOSINE; TANDEM MASS SPECTROMETRY;

EID: 84941695034     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-015-9008-4     Document Type: Article

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