Micro-droplet based directed evolution outperforms conventional laboratory evolution

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Volumn , Issue , 2015, Pages 169-171

  Sjostrom, Staffan L ^a   Huang, Mingtao ^b   Nielsen, Jens ^a,b,c   Joensson, Haakan N ^a   Andersson Svahn, Helene ^a  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c Chalmers University of Technology   (Denmark)

Author keywords

Cell factories; Directed evolution; Droplet microfluidics; Enzymes; High throughput

Indexed keywords

CELLS; DROPS; ENZYMES; MICROFLUIDICS;

ALPHA-AMYLASE ACTIVITY; DIRECTED EVOLUTION; DIRECTED EVOLUTION METHODS; DROPLET MICROFLUIDICS; HIGH THROUGHPUT; INDUSTRIAL ENZYMES; MICRO DROPLETS; MICROFLUIDIC DROPLETS;

CYTOLOGY;

EID: 84941686278     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (3)

1. M. Dragosits and D. Mattanovich, "Adaptive laboratory evolution - principles and applications for biotechnology", Microbial Cell Factories, 12, 2013.
2. S. L. Sjostrom, Y. Bai, M. Huang, Z. Liu, J. Nielsen, H. N. Joensson and H. Andersson Svahn, "High-Throughput screening for industrial enzyme production hosts by droplet microfludics", Lab Chip, 14, 2014.
3. H. Bachmann, M. Fischlechner, I. Rabbers, N. Barfa, F. Branco dos Santos, D. Molenaar and B. Teusink, "Availability of public goods shapes the evolution of competing metabolic strategies", Proc. Natl. Acad. Sci. U. S. A., 2013.