Prokineticin ligands and receptors are expressed in the human fetal ovary and regulate germ cell expression of COX2

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 9, 2015, Pages E1197-E1205

  Eddie, Sharon L ^a,c   Childs, Andrew J ^a,d   Kinnell, Hazel L ^a   Brown, Pamela ^a,b   Jabbour, Henry N ^a   Anderson, Richard A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^d ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYCLOOXYGENASE 2; ENDOCRINE GLAND DERIVED VASCULAR ENDOTHELIAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROKINETICIN 2; PROKINETICIN RECEPTOR 1; RECEPTOR; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; NEUROPEPTIDE; PROK1 PROTEIN, HUMAN; PROK2 PROTEIN, HUMAN; PROKR1 PROTEIN, HUMAN; PROKR2 PROTEIN, HUMAN;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NORMAL HUMAN; OOCYTE; OVARY; OVARY DEVELOPMENT; OVARY FOLLICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; DRUG EFFECTS; EMBRYOLOGY; FETUS DEVELOPMENT; GENETICS; GERM CELL; METABOLISM; PHOSPHORYLATION;

CYCLOOXYGENASE 2; FEMALE; FETAL DEVELOPMENT; GASTROINTESTINAL HORMONES; GERM CELLS; HUMANS; NEUROPEPTIDES; OVARY; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR, ENDOCRINE-GLAND-DERIVED;

EID: 84941662762     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2015-2330     Document Type: Article

References (40)

1. Edson MA, Nagaraja AK, Matzuk MM. The mammalian ovary from genesis to revelation. Endocr Rev. 2009;30:624-712.
2. McGee EA, Hsueh AJ. Initial and cyclic recruitment of ovarian follicles. Endocr Rev. 2000;21:200-214.
3. De Felici M. Regulation of primordial germ cell development in the mouse. Int J Dev Biol. 2000;44:575-580.
4. Kerr JB, Myers M, Anderson RA. Dynamics of primordial follicle reserve. Reproduction. 2013;146(6):R205-R215.
5. Ngan ES, Tam PK. Prokineticin-signaling pathway. Int J Biochem Cell Biol. 2008;40:1679-1684.
6. Soga T, Matsumoto S, Oda T, et al. Molecular cloning and characterization of prokineticin receptors. Biochim Biophys Acta. 2002; 1579:173-179.
7. Masuda Y, Takatsu Y, Terao Y, et al. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem Biophys Res Commun. 2002;293: 396-402.
8. LeCouter J, Zlot C, TejadaM,Peale F, Ferrara N. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad SciU S A. 2004;101:16813-16818.
9. WadePR, Palmer JM,MabusJ, et al. Prokineticin-1 evokes secretory and contractile activity in rat small intestine. Neurogastroenterol Motil. 2010;22:e152-e161.
10. Wechselberger C, Puglisi R, Engel E, Lepperdinger G, Boitani C, Kreil G. The mammalian homologues of frog Bv8 are mainly expressed in spermatocytes. FEBS Lett. 1999;462:177-181.
11. Evans J, Catalano RD, Morgan K, Critchley HO, Millar RP, Jabbour HN. Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology. 2008;149:2877-2887.
12. Ferrara N, Frantz G, LeCouter J, et al. Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derivedVEGFin normal and polycystic human ovaries. Am J Pathol. 2003;162:1881-1893.
13. Kisliouk T, Levy N, Hurwitz A, Meidan R. Presence and regulation of endocrine gland vascular endothelial growth factor/prokineticin-1 and its receptors in ovarian cells. J Clin Endocrinol Metab. 2003;88:3700-3707.
14. Houmard B, Small C, Yang L, et al. Global gene expression in the human fetal testis and ovary. Biol Reprod. 2009;81:438-443.
15. Fowler PA, Flannigan S, Mathers A, et al. Gene expression analysis of human fetal ovarian primordial follicle formation. J Clin Endocrinol Metab. 2009;94:1427-1435.
16. Evans J, Catalano RD, Brown P, et al. Prokineticin 1 mediates fetalmaternal dialogue regulating endometrial leukemia inhibitory factor. Faseb J. 2009;23:2165-2175.
17. Mizuno Y, Gotoh A, Kamidono S, Kitazawa S. [Establishment and characterization of a new human testicular germ cell tumor cell line (TCam-2)]. Nihon Hinyokika Gakkai Zasshi. 1993;84:1211-1218.
18. Friel A, Houghton JA, Glennon M, et al.Apreliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men. Int J Androl. 2002;25:59-64.
19. Bayne RA, Eddie SL, Collins CS, Childs AJ, Jabbour HN, Anderson RA. Prostaglandin E2 as a regulator of germ cells during ovarian development. J Clin Endocrinol Metab. 2009;94:4053-4060.
20. de Jong J, Stoop H, Gillis AJ, et al. Further characterization of the first seminoma cell line TCam-2. Genes Chromosomes Cancer. 2008;47:185-196.
21. Eckert D, Nettersheim D, Heukamp LC, Kitazawa S, Biermann K, Schorle H. TCam-2 but not JKT-1 cells resemble seminoma in cell culture. Cell Tissue Res. 2008;331:529-538.
22. Fulton N, Martins da Silva SJ, Bayne RA, Anderson RA. Germ cell proliferation and apoptosis in the developing human ovary. J Clin Endocrinol Metab. 2005;90:4664-4670.
23. Maheshwari A, Fowler PA. Primordial follicular assembly in humans-Revisited. Zygote. 2008;16:285-296.
24. Young JC, Jaiprakash A, Mithraprabhu S, et al. TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGFbeta ligands and retinoic acid. Int J Androl. 2011;34:e204-217.
25. Eddie SL, Childs AJ, Jabbour HN, Anderson RA. Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary. Mol Hum Reprod. 2012;18:88-95.
26. Faour WH, Gomi K, Kennedy CR. PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism. Cell Signal. 2008;20:2156-2164.
27. Steinert D, Kper C, Bartels H, Beck FX, Neuhofer W. PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling. Am J Physiol Cell Physiol. 2009;296:C75-C87.
28. Hoffmann P, Feige JJ, Alfaidy N. Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy. Endocrinology. 2006;147:1675-1684.
29. Shaw JL, Denison FC, Evans J, et al. Evidence of prokineticin dysregulation in fallopian tube from women with ectopic pregnancy. Fertil Steril. 2010;94:1601-1608.e1601.
30. Matsumoto S, Yamazaki C, Masumoto KH, et al. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006; 103:4140-4145.
31. Fraser HM, Bell J, Wilson H, et al. Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum. J Clin Endocrinol Metab. 2005;90:427-434.
32. LeCouter J, Ferrara N. EG-VEGF and Bv8. a novel family of tissueselective mediators of angiogenesis, endothelial phenotype, and function. Trends Cardiovasc Med. 2003;13:276-282.
33. Pepling ME, Spradling AC. Female mouse germ cells form synchronously dividing cysts. Development. 1998;125:3323-3328.
34. Hartley PS, Bayne RA, Robinson LL, Fulton N, Anderson RA. Developmental changes in expression of myeloid cell leukemia-1 in human germ cells during oogenesis and early folliculogenesis. J Clin Endocrinol Metab. 2002;87:3417-3427.
35. Otto JC, Smith WL. Prostaglandin endoperoxide synthases-1 and -2. J Lipid Mediat Cell Signal. 1995;12:139-156.
36. Anderson RA, Robinson LL, Brooks J, Spears N. Neurotropins and their receptors are expressed in the human fetal ovary. J Clin Endocrinol Metab. 2002;87:890-897.
37. Childs AJ, Bayne RA, Murray AA, et al. Differential Expression and Regulation by Activin of the NeurotrophinsBDNFandNT4During Human and Mouse Ovarian Development. Dev Dyn. 2010;239: 1211-1219.
38. Martins da Silva SJ, Bayne RA, Cambray N, Hartley PS, McNeilly AS, Anderson RA. Expression of activin subunits and receptors in the developing human ovary: Activin A promotes germ cell survival and proliferation before primordial follicle formation. Dev Biol. 2004;266:334-345.
39. Childs AJ, Anderson RA. Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary. Fertil Steril. 2009;92:1416-1419.
40. Jones RL, Pepling ME. Role of the antiapoptotic proteins BCL2 and MCL1 in the neonatal mouse ovary. Biol Reprod. 2013;88:46.