Effect of daily antenatal iron supplementation on plasmodium infection in kenyan women: A randomized clinical trial

JAMA - Journal of the American Medical Association

Volumn 314, Issue 10, 2015, Pages 1009-1020

  Mwangi, Martin N ^a   Roth, Johanna M ^a,c   Smit, Menno R ^a   Trijsburg, Laura ^a   Mwangi, Alice M ^b,d   Demir, Aye Y ^e   Wielders, Jos P M ^e   Mens, Petra F ^c   Verweij, Jaco J ^f   Cox, Sharon E ^g,h   Prentice, Andrew M ^g,h   Brouwer, Inge D ^a   Savelkoul, Huub F J ^a   Andang'O, Pauline E A ^b   Verhoef, Hans ^a,g,h  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b MASENO UNIVERSITY   (Kenya)

^c ROYAL TROPICAL INSTITUTE   (Netherlands)

^d UNIVERSITY OF NAIROBI   (Kenya)

^e MEANDER MEDICAL CENTER   (Netherlands)

^f CPRLab   (Netherlands)

^g MEDICAL RESEARCH COUNCIL   (United Kingdom)

^h MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FERROUS FUMARATE; PLACEBO; FERROUS ION; HEMOGLOBIN A; IRON;

ADOLESCENT; ADULT; ANEMIA; ARTICLE; BIRTH WEIGHT; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FERRITIN BLOOD LEVEL; GESTATIONAL AGE; HEMOGLOBIN DETERMINATION; HUMAN; INFECTION RISK; KENYAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MATERNAL NUTRITION; OUTCOME ASSESSMENT; PRENATAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; RURAL AREA; WOMEN'S HEALTH; ADVERSE EFFECTS; DIET SUPPLEMENTATION; KENYA; MALARIA, FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; RURAL POPULATION;

ADOLESCENT; ADULT; BIRTH WEIGHT; DIETARY SUPPLEMENTS; FEMALE; FERROUS COMPOUNDS; GESTATIONAL AGE; HEMOGLOBIN A; HUMANS; IRON; KENYA; MALARIA, FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PRENATAL CARE; RURAL POPULATION;

EID: 84941650569     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.9496     Document Type: Article

References (38)

1. De Benois B, McLean E, Egli I, Cogswell M, eds. Worldwide Prevalence of Anaemia 1993-2005: WHO Global Database on Anaemia. Geneva, Switzerland: World Health Organization; 2008.
2. Iron deficiency anaemia: report of a study group [29 September to 4 October 1958]. World Health Organization. http://www.who.int/nutrition/publications/micronutrients/anaemia-iron-deficiency/WHO-TRS-182/en/. Accessed August 13, 2015.
3. Galloway R, McGuire J. Determinants of compliance with iron supplementation: supplies, side effects, or psychology? Soc Sci Med. 1994;39 (3):381-390.
4. Mason J, Lotfi M, Dalmiya N, Sethuraman K, Deitchler M. The Micronutrient Report: Current Progress and Trends in the Control of Vitamin A, Iodine, and Iron Deficiencies. Ottawa, ON: Micronutrient Initiative; 2001.
5. Peña-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev. 2009;(4):CD004736.
6. McCarthy M. Evidence for iron deficiency screening "inadequate, " US panel concludes. BMJ. 2015;350:h1841.
7. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet. 2006;367(9505): 133-143.
8. Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131 (2S-2):616S-633S.
9. Guideline: daily iron and folic acid supplementation in pregnant women. World Health Organization. http://apps.who.int/iris/bitstream/10665/77770/1/9789241501996-eng.pdf. Accessed August 13, 2015.
10. Sangaré L, van Eijk AM, Ter Kuile FO, Walson J, Stergachis A. The association between malaria and iron status or supplementation in pregnancy: a systematic review and meta-analysis. PLoS One. 2014;9(2):e87743.
11. Menendez C, Todd J, Alonso PL, et al. The effects of iron supplementation during pregnancy, given by traditional birth attendants, on the prevalence of anaemia and malaria. Trans R Soc Trop Med Hyg. 1994;88(5):590-593.
12. Desai M, ter Kuile FO, Nosten F, et al. Epidemiology and burden of malaria in pregnancy. Lancet Infect Dis. 2007;7(2):93-104.
13. WHO policy brief for the implementation of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP): April 2013 (revised January 2014). World Health Organization. http://www.who.int/malaria/publications/atoz/iptp-sp-updated-policy-brief-24jan2014.pdf?ua=1. Accessed August 13, 2015.
14. Kenya National Technical Guidelines for Micronutrient Deficiency Control. Nairobi, Kenya: Ministry of Public Health and Sanitation; 2008.
15. National Guidelines for the Diagnosis, Treatment, and Prevention of Malaria in Kenya. 3rd ed. Nairobi, Kenya: Ministry of Public Health and Sanitation/Ministry of Medical Services; 2010.
16. Kenya Demographic and Health Survey 2008-09. Calverton, MD: Kenya National Bureau of Statistics/ICF Macro; 2010.
17. Beaton GH. Iron needs during pregnancy: do we need to rethink our targets? Am J Clin Nutr. 2000; 72(1)(suppl):265S-271S.
18. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: US Institute of Medicine; 2001.
19. Othoro C, Moore JM, Wannemuehler K, et al. Evaluation of various methods of maternal placental blood collection for immunology studies. Clin Vaccine Immunol. 2006;13(5):568-574.
20. Moody A. Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev. 2002;15(1):66-78.
21. Bulmer JN, Rasheed FN, Francis N, Morrison L, Greenwood BM. Placental malaria: I: Pathological classification. Histopathology. 1993;22(3):211-218.
22. Mikolajczyk RT, Zhang J, Betran AP, et al. A global reference for fetal-weight and birthweight percentiles. Lancet. 2011;377(9780):1855-1861.
23. Veenemans J, Milligan P, Prentice AM, et al. Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial. PLoS Med. 2011;8(11):e1001125.
24. Clark MA, Goheen MM, Fulford A, et al. Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. Nat Commun. 2014;5:4446.
25. Puma MJ, Olsen RB, Bell SH, Price C. What to Do When Data Are Missing in Group Randomized Controlled Trials (NCEE 2009-0049). Washington, DC: US Dept of Education; 2009.
26. Cottrell G, Deloron P, Fievet N, Sow S, Gaye O, Le Hesran J-Y. Prediction of Plasmodium falciparum placental infection according to the time of infection during pregnancy. Acta Trop. 2006;98(3): 255-260.
27. Peña-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012;12: CD004736.
28. Vucic V, Berti C, Vollhardt C, et al. Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis. Nutr Rev. 2013;71(6):386-401.
29. Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW; Nutrition Impact Model Study Group (anaemia). Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ. 2013;346:f3443.
30. Zeng L, Dibley MJ, Cheng Y, et al. Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial. BMJ. 2008;337: a2001.
31. Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM. Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr. 2003;78(4):773-781.
32. Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL. How often is medication taken as prescribed? a novel assessment technique. JAMA. 1989;261(22):3273-3277.
33. Olivieri NF, Matsui D, Hermann C, Koren G. Compliance assessed by the Medication Event Monitoring System. Arch Dis Child. 1991;66(12): 1399-1402.
34. Kayentao K, Garner P, van Eijk AM, et al. Intermittent preventive therapy for malaria during pregnancy using 2 vs 3 or more doses of sulfadoxine-pyrimethamine and risk of low birth weight in Africa: systematic review and meta-analysis. JAMA. 2013;309(6):594-604.
35. Low Birthweight: Country, Regional and Global Estimates. Geneva, Switzerland: UN Children's Fund/World Health Organization; 2004.
36. Scholl TO. Maternal iron status: relation to fetal growth, length of gestation, and iron endowment of the neonate. Nutr Rev. 2011;69(suppl 1):S23-S29.
37. Preziosi P, Prual A, Galan P, Daouda H, Boureima H, Hercberg S. Effect of iron supplementation on the iron status of pregnant women: consequences for newborns. Am J Clin Nutr. 1997;66(5):1178-1182.
38. Prentice AM, Cox SE. Iron and malaria interactions: research needs from basic science to global policy. Adv Nutr. 2012;3(4):583-591.