Non-anaemic iron deficiency in COPD: A potential therapeutic target?

Respirology

Volumn 20, Issue 7, 2015, Pages 1004-1005

  Boutou, Afroditi K ^a,b   Polkey, Michael I ^c   Hopkinson, Nicholas S ^c  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b G Genimatas Hospital   (Greece)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

chronic obstructive pulmonary disease; exercise capacity; non anaemic iron deficiency; pulmonary rehabilitation

Indexed keywords

IRON;

CHRONIC OBSTRUCTIVE LUNG DISEASE; CONGESTIVE HEART FAILURE; EDITORIAL; EXERCISE; EXERCISE TOLERANCE; HUMAN; IRON DEFICIENCY; MORBIDITY; NON ANEMIC IRON DEFICIENCY; PREVALENCE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; PULMONARY REHABILITATION; QUALITY OF LIFE; SURVIVAL;

EID: 84941601129     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12616     Document Type: Editorial

References (14)

1. Chen C, Paw BH,. Cellular and mitochondrial iron homeostasis in vertebrates. Biochim. Biophys. Acta 2012; 1823: 1459-1467.
2. Silverberg D, Iaina A, Wexler D, Schwartz D,. Iron repletion in heart failure patients. Hypertension 2011; 57: 381-382.
3. Brownlie T 4th, Utermohlen V, Hinton PS, Haas JD,. Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women. Am. J. Clin. Nutr. 2004; 79: 437-443.
4. Corti MC, Guralnik JM, Salive ME, Ferrucci L, Pahor M, Wallace RB, Hennekens CH,. Serum iron level, coronary artery disease, and all-cause mortality in older men and women. Am. J. Cardiol. 1997; 79: 120-127.
5. Okonko DO, Mandal AK, Missouris CG, Poole-Wilson PA,. Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival. J. Am. Coll. Cardiol. 2011; 58: 1241-1251.
6. Rhodes CJ, Howard LS, Busbridge M, Ashby D, Kondili E, Gibbs JS, Wharton J, Wilkins MR,. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights. J. Am. Coll. Cardiol. 2011; 58: 300-309.
7. Boutou AK, Hopkinson NS, Polkey MI,. Anaemia in chronic obstructive pulmonary disease: an insight into its prevalence and pathophysiology. Clin. Sci. (Lond.) 2015; 128: 283-295.
8. Obase Y, Mouri K, Shimizu H, Ohue Y, Kobashi Y, Kawahara K, Oka M,. Nutritional deficits in elderly smokers with respiratory symptoms that do not fulfill the criteria for COPD. Int J Chron Obstruct Pulmon Dis. 2011; 6: 679-683.
9. Boutou AK, Stanopoulos I, Pitsiou GG, Kontakiotis T, Kyriazis G, Sichletidis L, Argyropoulou P,. Anemia of chronic disease in chronic obstructive pulmonary disease: a case-control study of cardiopulmonary exercise responses. Respiration 2011; 82: 237-245.
10. Boutou AK, Karrar S, Hopkinson NS, Polkey MI,. Anemia and survival in chronic obstructive pulmonary disease: a dichotomous rather than a continuous predictor. Respiration 2013; 85: 126-131.
11. Selzler A-M, Simmonds L, Rodgers WM, Wong EY, Stickland MK,. Pulmonary rehabilitation in chronic obstructive pulmonary disease: predictors of program completion and success. COPD 2012; 9: 538-545.
12. Troosters T, Gosselink R, Decramer M,. Exercise training in COPD: how to distinguish responders from nonresponders. J. Cardiopulm. Rehabil. 2001; 21: 10-17.
13. Boutou AK, Tanner RJ, Lord VM, Hogg L, Nolan J, Jefford H, Corner EJ, Falzon C, Lee C, Garrod R, et al., An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD. BMJ Open Respir Res. 2014; 1: e000051.
14. Barberan-Garcia A, Rodríguez DA, Blanco I, Gea J, Torralba Y, Arbillaga-Etxarri A, Barberà JA, Vilarõ J, Roca J, Orozco-Levi M,. Non-anaemic iron deficiency impairs response to pulmonary rehabilitation in COPD. Respirology 2015; 20: 1089-1095.