[99mTc]Tilmanocept Accurately Detects Sentinel Lymph Nodes and Predicts Node Pathology Status in Patients with Oral Squamous Cell Carcinoma of the Head and Neck: Results of a Phase III Multi-institutional Trial

Annals of Surgical Oncology

Volumn 22, Issue 11, 2015, Pages 3708-3715

  Agrawal, Amit ^a   Civantos, Francisco J ^b   Brumund, Kevin T ^c   Chepeha, Douglas B ^d   Hall, Nathan C ^e   Carroll, William R ^f   Smith, Russell B ^g   Zitsch, Robert P ^h   Lee, Walter T ⁱ   Shnayder, Yelizaveta ^j   Cognetti, David M ^k   Pitman, Karen T ^l   King, Dennis W ^m   Christman, Lori A ^m   Lai, Stephen Y ⁿ  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MIAMI HOSPITAL   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^h University of Missouri   (United States)

ⁱ DUKE UNIVERSITY MEDICAL CENTER   (United States)

^j UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^k THOMAS JEFFERSON UNIVERSITY   (United States)

^l Banner MD Anderson Cancer Center   (United States)

^m STATKING Clinical Services   (United States)

ⁿ UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TILMANOCEPT TC 99M; DEXTRAN; MANNAN; PENTETATE TECHNETIUM TC 99M; RADIOPHARMACEUTICAL AGENT; TECHNETIUM-DIETHYLENETRIAMINEPENTAACETIC ACID-MANNOSYL-DEXTRAN;

ADULT; ARTICLE; CANCER PROGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE NEGATIVE RESULT; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPHOSCINTIGRAPHY; MAJOR CLINICAL STUDY; MOUTH SQUAMOUS CELL CARCINOMA; MULTICENTER STUDY; OPEN STUDY; PHASE 3 CLINICAL TRIAL; PREDICTIVE VALUE; SENTINEL LYMPH NODE BIOPSY; SENTINEL LYMPH NODE METASTASIS; ANALOGS AND DERIVATIVES; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIAL; DIAGNOSTIC IMAGING; LYMPH NODE; LYMPH NODE METASTASIS; MOUTH NEOPLASMS; NECK; NECK DISSECTION; PATHOLOGY; PROCEDURES; SECONDARY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

CARCINOMA, SQUAMOUS CELL; DEXTRANS; FALSE NEGATIVE REACTIONS; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; LYMPHOSCINTIGRAPHY; MANNANS; MOUTH NEOPLASMS; NECK; NECK DISSECTION; PREDICTIVE VALUE OF TESTS; RADIOPHARMACEUTICALS; SENTINEL LYMPH NODE BIOPSY; TECHNETIUM TC 99M PENTETATE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84941416366     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-015-4382-x     Document Type: Article

References (22)

1. Alvi A, Johnson JT. Extracapsular spread in the clinically negative neck (N0): implications and outcome. Otolaryngol Head Neck Surg. 1996;114:65–70.
2. Mamelle G, Pampurik J, Luboinski B, et al. Lymph node prognostic factors in head and neck squamous cell carcinomas. Am J Surg. 1994;168:494–8.
3. Rassekh CH, Johnson JT, Myers EN. Accuracy of intraoperative staging of the N0 neck in squamous cell carcinoma. Laryngoscope. 1995;105:1334–6.
4. de Bondt RB, Nelemans PJ, Hofman PA, et al. Detection of lymph node metastases in head and neck cancer: a meta-analysis comparing US, USgFNAC, CT and MR imaging. Eur J Radiol. 2007; 64:266–72.
5. Kyzas PA, Evangelou E, Denaxa-Kyza D, Ioannidis JP. 18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst. 2008;100:712–20.
6. Yuen AP, Wei WI, Wong YM, et al. Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck. 1997; 19:583–8.
7. Chepeha DB, Taylor RJ, Chepeha JC, et al. Functional assessment using Constant’s Shoulder Scale after modified radical and selective neck dissection. Head Neck. 2002;24:432–6.
8. Rogers SN, Ferlito A, Pellitteri PK, et al. Quality of life following neck dissections. Acta Otolaryngol. 2004;124:231–6.
9. Schiefke F, Akdemir M, Weber A, et al. Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection. Head Neck. 2009;31:503–12.
10. Schmitz S, Machiels JP, Weynand B, et al. Results of selective neck dissection in the primary management of head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2009;266:437–43.
11. Chone CT, Magalhes RS, Etchehebere E, et al. Predictive value of sentinel node biopsy in head and neck cancer. Acta Otolaryngol. 2008;128:920–4.
12. Bilde A, von Buchwald C, Therkildsen MH, et al. Need for intensive histopathologic analysis to determine lymph node metastases when using sentinel node biopsy in oral cancer. Laryngoscope. 2008;118:408–14.
13. Civantos FJ, Moffat FL, Goodwin WJ. Lymphatic mapping and sentinel lymphadenectomy for 106 head and neck lesions: contrasts between oral cavity and cutaneous malignancy. Laryngoscope. 2006;112:1–15.
14. Civantos FJ, Zitsch RP, Schuller DE, et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1–T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial. J Clin Oncol. 2010;28:1395–400.
15. Shoaib T, Soutar DS, MacDonald DG, et al. The accuracy of head and neck carcinoma sentinel lymph node biopsy in the clinically N0 neck. Cancer. 2001;91:2077–83.
16. Zitsch RP 3rd, Todd DW, Renner GJ, et al. Intraoperative radiolymphoscintigraphy for detection of occult nodal metastasis in patients with head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2000;122:662–6.
17. Civantos FJ, Gomez C, Duque C, et al. Sentinel node biopsy in oral cavity cancer: correlation with PET scan and immunohistochemistry. Head Neck. 2003;25:1–9.
18. Alkureishi LW, Ross GL, Shoaib T, et al. Sentinel node biopsy in head and neck squamous cell cancer: 5-year follow-up of a European multicenter trial. Ann Surg Oncol. 2010;17:2459–64.
19. Vera DR, Wallace AM, Hoh CK, et al. A synthetic macromolecule for sentinel node detection: (99m)Tc-DTPA-mannosyl-dextra. J Nucl Med. 2001;42:951–9.
20. Ross GL, Soutar DS, MacDonald GD, et al. Sentinel node biopsy in head and neck cancer: preliminary results of a multicenter trial. Ann Surg Oncol. 2004;11:690–6.
21. 99mTc-sulfur colloid in head/neck squamous cell cancer. In: Society of nuclear medicine and molecular imaging annual meeting, 11 Jun 2013, Vancouver.
22. Wallace AM, Hoh CK, Limmera KK, et al. Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a “2-day” protocol. Nucl Med Biol. 2009;36:687–692.