Synergy assessment of fixed combinations of Herba Andrographidis and Radix Eleutherococci extracts by transcriptome-wide microarray profiling

Phytomedicine

Volumn 22, Issue 11, 2015, Pages 981-992

  Panossian, Alexander ^a   Seo, Ean Jeong ^b   Wikman, Georg ^a   Efferth, Thomas ^b  

^a Swedish Herbal Institute   (Sweden)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Acanthaceae; Araliaceae; Network pharmacology; Pharmacogenomics; Synergy; Venn diagrams

Indexed keywords

ACOT7 PROTEIN; ANDROGRAPHOLIDE; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3F; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; ASS1 PROTEIN; F2RL2 PROTEIN; GABA TRANSPORTER 1; GBP1 PROTEIN; GLDN PROTEIN; HERBA ANDROGRAPHIDIS EXTRACT; HIST1H2AC PROTEIN; IFI35 PROTEIN; IFIT1 PROTEIN; IFITM1 PROTEIN; IFITM3 PROTEIN; KRT18 PROTEIN; LYPD1 PROTEIN; MESSENGER RNA; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; ORGANIC ANION TRANSPORTER B; PLANT EXTRACT; PROTEIN; PSMB8 PROTEIN; RADIX ELEUTHEROCOCCI EXTRACT; RCAN1 PROTEIN; RNA; RNY4 PROTEIN; SRXN1 PROTEIN; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELL ISOLATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENTIATION; ENCEPHALITIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLIA CELL; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MICROARRAY ANALYSIS; MOTOR DYSFUNCTION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RNA ANALYSIS; THERAPY EFFECT; UPREGULATION; ANDROGRAPHIS; CELL LINE; CHEMISTRY; DRUG EFFECTS; ELEUTHEROCOCCUS; GENE EXPRESSION REGULATION; GLIA; PLANT ROOT;

ANDROGRAPHIS; CELL LINE; DRUG SYNERGISM; ELEUTHEROCOCCUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICROARRAY ANALYSIS; NEUROGLIA; PLANT EXTRACTS; PLANT ROOTS;

EID: 84941341390     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.08.004     Document Type: Article

References (24)

1. ® - a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever Phytomedicine 10 2003 271 285
2. Burgos R.A.; Seguel K.; Perez M.; Meneses A.; Ortega M.; Guarda M.I.; Loaiza A.; Hancke J.L. Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis Planta Med. 71 2005 429 434
3. Dejager L.; Vandevyver S.; Ballegeer M.; Van Wonterghem E.; An L.L.; Riggs J.; Kolbeck R.; Libert C. Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis J. Infect. Dis. 209 2014 960 970
4. Denzler K.L.; Waters R.; Jacobs B.L.; Rochon Y.; Langland J.O. Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals PLoS One 5 e12561 2010 1 15
5. Efferth T.; Koch E. Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy Curr. Drug Targ. 12 2011 122 132
6. ESCOP Monographs Eleutherococci Radix: The Scientific Foundation of Herbal Medicinal Products, 2nd ed. European Scientific Cooperative Phytotherapy (ESCOP) Monographs 2nd ed. 2003 European Scientific Cooperative on Phytotherapy and Thieme Exeter (UK) 142 149
7. Farnsworth N.R.; Kinghorn A.D.; Soejarto D.D.; Waller D.P. Siberian ginseng (Eleuherococcus senticosus): current status as an adaptogen Wagner H. Hikino H. Farnsworth N.R. Economic and Medicinal Plant Research vol. 1 1985 Academic Press London 155 215
8. Gabrielian E.S.; Shukarian A.K.; Goukasova G.I.; Chandanian G.L.; Panossian A.G.; Wikman G.; Wagner H. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis Phytomedicine 9 2002 589 597
9. Herba Andrographidis WHO Monographs on Selected Medicinal Plants vol. 2 2002 WHO Geneva 12 24 2002
10. Herba Andrographis (Chuanxinlian) Pharmacopoeia of the People's Republic of China 2010 (English Ed.) vol. 1 2010 China Medical Science Press Beijing, China 32 33
11. Kulichenko L.L.; Kireyeva L.V.; Malyshkina E.N.; Wikman G. A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd J. Herb. Pharmacother. 3 2003 77 93
12. Lateef A.; Petria M. Biologics in the treatment of systemic lupus erythematosus Curr. Opin. Rheumatol. 22 2010 504 509
13. Panossian A.; Hovhannisyan A.; Mamikonyan G.; Abrahamian H.; Hambardzumyan E.; Gabrielian E.; Goukasova G.; Wikman G.; Wagner H. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human Phytomedicine 7 2000 351 364
14. Panossian A.; Davtyan T.; Gukassyan N.; Gukasova G.; Mamikonyan G.; Gabrielyan E.; Wikman G. Effect of andrographolide and Kan Jang - fixed combination of extract SHA-10 and extract SHE-3 - on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture Phytomedicine 90 2002 598 605
15. Panossian A.; Hamm R.; Kadioglu O.; Wikman G.; Efferth T. Synergy and antagonism of active constituents of ADAPT-232 on transcriptional level of metabolic regulation of isolated neuroglial cells Front Neurosci 7 2013 16 http://journal.frontiersin.org/article/10.3389/fnins.2013.00016/abstract
16. Panossian A.; Wikman G. Efficacy of Andrographis paniculata in upper respiratory tract (URT) infectious diseases and the mechanism of action H. Wagner G. Ulrich Merzenich Evidence and Rational Based Research on Chinese Drugs 2012 Springer 137 180
17. Parichatikanond W.; Suthisisang C.; Dhepakson P.; Herunsalee A. Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm. f.) Nees and their effects on gene expression Int. Immunopharmacol. 10 2010 1361 1373
18. Puri A.; Saxena R.; Saxena R.P.; Saxena K.C.; Srivastava V.; Tandon J.S. Immunostimulant agents from Andrographis paniculata J. Nat. Prod. 56 1993 995 999
19. Radix Eleutherococci WHO Monographs on Selected Medicinal Plants vol. 2 2002 WHO Geneva 83 96 2002
20. Radix et, Rhizoma seu Caulis Acanthopanacis Senticosi (Ciwaujia) Pharmacopoeia of the People's Republic of China 2005 (English Ed.) 1 2005 People's Medical Publishing House Beijing, China 121
21. Rosenblueth M.; Martinez-Romero E. Bacterial endophytes and their interactions with hosts Mol. Plant Microbe Interact. 19 2006 827 837
22. Skurkovich B.; Skurkovich S. Inhibition of IFN-gamma as a method of treatment of various autoimmune diseases, including skin diseases Ernst Schering Res. Found. Workshop. 56 2006 1 27
23. Strobel G.; Daisy B. Bioprospecting for microbial endophytes and their natural products Microbiol. Mol. Biol. Rev. 67 2003 491 502
24. Wagner H. Multitarget therapy - the future of treatment for more than just functional dyspepsia Phytomedicine. 5 2006 122 129