Aggregation of polyglutamine-expanded ataxin 7 protein specifically sequesters ubiquitin-specific protease 22 and deteriorates its deubiquitinating function in the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex

Journal of Biological Chemistry

Volumn 290, Issue 36, 2015, Pages 21996-22004

  Yang, Hui ^a   Liu, Shuai ^a   He, Wen Tian ^a   Zhao, Jian ^a   Jiang, Lei Lei ^a   Hu, Hong Yu ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; EXPANSION; ZINC;

ACETYL TRANSFERASE; DE-UBIQUITINATING ACTIVITY; INSOLUBLE AGGREGATES; POLYGLUTAMINE (POLYQ); SAGA COMPLEXES; TRANSCRIPTIONAL DYSREGULATION; TRANSCRIPTIONAL REGULATION; ZINC FINGER DOMAINS;

PROTEINS;

ATAXIN 7; DEUBIQUITINASE; POLYGLUTAMINE; TRANSCRIPTION FACTOR SAGA; UBIQUITIN SPECIFIC PROTEASE 22; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; HISTONE; HISTONE ACETYLTRANSFERASE; MULTIENZYME COMPLEX; PEPTIDE; PROTEIN AGGREGATE; PROTEIN BINDING; THIOL ESTER HYDROLASE; USP22 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME INACTIVATION; HISTONE UBIQUITINATION; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; BINDING SITE; FLUORESCENCE MICROSCOPY; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; SPINOCEREBELLAR DEGENERATION; TRINUCLEOTIDE REPEAT; UBIQUITINATION; WESTERN BLOTTING;

ATAXIN-7; BINDING SITES; BLOTTING, WESTERN; HEK293 CELLS; HELA CELLS; HISTONE ACETYLTRANSFERASES; HISTONES; HUMANS; MICROSCOPY, FLUORESCENCE; MULTIENZYME COMPLEXES; MUTATION; PEPTIDES; PROTEIN AGGREGATES; PROTEIN BINDING; SPINOCEREBELLAR ATAXIAS; THIOLESTER HYDROLASES; TRINUCLEOTIDE REPEAT EXPANSION; UBIQUITINATION; ZINC FINGERS;

EID: 84941312987     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.631663     Document Type: Article

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