Bullying victimization in childhood predicts inflammation and obesity at mid-life: A five-decade birth cohort study

Psychological Medicine

Volumn 45, Issue 13, 2015, Pages 2705-2715

  Takizawa, R ^a,b   Danese, A ^a,c,d   Maughan, B ^a   Arseneault, L ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF TOKYO   (Japan)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Bullying victimization; epidemiology; inflammation; longitudinal studies; obesity

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN;

ADOLESCENT; ADULT; ANXIETY; BODY MASS; BULLYING; CHILD; CHILD ABUSE SURVIVOR; DEPRESSION; FEMALE; GREAT BRITAIN; HUMAN; INFLAMMATION; LONGITUDINAL STUDY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; ADULT SURVIVORS OF CHILD ABUSE; ANXIETY; BIOMARKERS; BODY MASS INDEX; BULLYING; C-REACTIVE PROTEIN; CHILD; DEPRESSION; FEMALE; GREAT BRITAIN; HUMANS; INFLAMMATION; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; YOUNG ADULT;

EID: 84941253879     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291715000653     Document Type: Article

References (51)

1. Anda RF, Croft JB, Felitti VJ, Nordenberg D, Giles WH, Williamson DF, Giovino GA (1999). Adverse childhood experiences and smoking during adolescence and adulthood. Journal of the American Medical Association 282, 1652-1658
2. Arseneault L, Bowes L, Shakoor S (2010). Bullying victimization in youths and mental health problems: 'much ado about nothing'? Psychological Medicine 40, 717-729
3. Arseneault L, Cannon M, Fisher HL, Polanczyk G, Moffitt TE, Caspi A (2011). Childhood trauma and children's emerging psychotic symptoms: a genetically sensitive longitudinal cohort study. American Journal of Psychiatry 168, 65-72
4. Babor T, Higgins-Biddle J, Saunders J, Monteiro M (2001). The Alcohol Use Disorders Identification Test, Guidelines for Use in Primary Care. World Health Organization: Geneva
5. Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA (1998). Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. New England Journal of Medicine 338, 1650-1656
6. Bond L, Carlin JB, Thomas L, Rubin K, Patton G (2001). Does bullying cause emotional problems? A prospective study of young teenagers. BMJ 323, 480-484
7. Braunwald E (1997). Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. New England Journal of Medicine 337, 1360-1369
8. Brent DA, Silverstein M (2013). Shedding light on the long shadow of childhood adversity. Journal of the American Medical Association 309, 1777-1778
9. Christensen K, Doblhammer G, Rau R, Vaupel JW (2009). Ageing populations: the challenges ahead. Lancet 374, 1196-1208
10. Clark C, Rodgers B, Caldwell T, Power C, Stansfeld S (2007). Childhood and adulthood psychological ill health as predictors of midlife affective and anxiety disorders: the 1958 British Birth Cohort. Archives of General Psychiatry 64, 668-678
11. Cole SW, Conti G, Arevalo JM, Ruggiero AM, Heckman JJ, Suomi SJ (2012). Transcriptional modulation of the developing immune system by early life social adversity. Proceedings of the National Academy of Sciences of the United States of America 109, 20578-20583
12. Conti G, Hansman C, Heckman JJ, Novak MF, Ruggiero A, Suomi SJ (2012). Primate evidence on the late health effects of early-life adversity. Proceedings of the National Academy of Sciences of the United States of America 109, 8866-8871
13. Copeland WE, Wolke D, Lereya ST, Shanahan L, Worthman C, Costello EJ (2014). Childhood bullying involvement predicts low-grade systemic inflammation into adulthood. Proceedings of the National Academy of Sciences of the United States of America 111, 7570-7575
14. Danese A, McEwen BS (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology and Behavior 106, 29-39
15. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences of the United States of America 104, 1319-1324
16. Danese A, Tan M (2014). Childhood maltreatment and obesity: systematic review and meta-analysis. Molecular Psychiatry 19, 544-554
17. Douglas JWB (1964). The Home and the School. MacGibbon &Kee: London
18. Ebrahim S, Beswick A, Burke M, Davey Smith G (2006). Multiple risk factor interventions for primary prevention of coronary heart disease. Cochrane Database of Systematic Reviews, Issue 1. Art. no. CD001561. doi:10.1002/14651858. CD001561.pub3
19. Fisher HL, Moffitt TE, Houts RM, Belsky DW, Arseneault L, Caspi A (2012). Bullying victimisation and risk of self harm in early adolescence: longitudinal cohort study. BMJ 344, e2683
20. Gilbert R, Widom CS, Browne K, Fergusson D, Webb E, Janson S (2009). Burden and consequences of child maltreatment in high-income countries. Lancet 373, 68-81
21. Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, Butterworth AS, Amouyel P, Assmann G, Bakker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Bjorkelund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D'Agostino Sr, RB, Dankner R, Davey-Smith G, Deeg D, Dekker JM, Engstrom G, Folsom AR, Fowkes FG, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jorgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Stehouwer CD, Strandberg TE, Tipping RW, Tosetto A, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GD, Wareham NJ, Khaw KT, Sattar N, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J (2012). C-reactive protein, fibrinogen, and cardiovascular disease prediction. New England Journal of Medicine 367, 1310-1320
22. Lewis G, Pelosi AJ, Araya R, Dunn G (1992). Measuring psychiatric disorder in the community: a standardized assessment for use by lay interviewers. Psychological Medicine 22, 465-486
23. Luppino FS, de Wit LM, Bouvy PF, Stijnen T, Cuijpers P, Penninx BW, Zitman FG (2010). Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Archives of General Psychiatry 67, 220-229
24. Matthews KA, Chang YF, Thurston RC, Bromberger JT (2014). Child abuse is related to inflammation in mid-life women: role of obesity. Brain, Behavior, and Immunity 36, 29-34
25. Midei AJ, Matthews KA (2011). Interpersonal violence in childhood as a risk factor for obesity: a systematic review of the literature and proposed pathways. Obesity Reviews 12, e159-e172
26. Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous SA, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen HL, Cheng ATA, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, De Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FGR, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KMV, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leon FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJC, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JRA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang MR, Wang WZ, Watt K, Weatherall DJ, Weinstock MA, Weintraub R,Weisskopf MG,Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SRM, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AKM, Zheng ZJ, Zonies D, Lopez AD (2012). Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2197-2223
27. Nansel TR, Craig W, Overpeck MD, Saluja G, Ruan WJ (2004). Cross-national consistency in the relationship between bullying behaviors and psychosocial adjustment. Archives of Pediatrics and Adolescent Medicine 158, 730-736
28. Nansel TR, Overpeck M, Pilla RS, Ruan WJ, Simons-Morton B, Scheidt P (2001). Bullying behaviors among US youth: prevalence and association with psychosocial adjustment. Journal of the American Medical Association 285, 2094-2100
29. Office of Population Censuses and Surveys (1980). Classification of Occupations. HMSO: London
30. Olweus D (1993). Bullying at School: What We Know and What We Can Do. Blackwell Publishers: Oxford
31. Ouellet-Morin I, Danese A, Bowes L, Shakoor S, Ambler A, Pariante CM, Papadopoulos AS, Caspi A, Moffitt TE, Arseneault L (2011a). A discordant monozygotic twin design shows blunted cortisol reactivity among bullied children. Journal of the American Academy of Child and Adolescent Psychiatry 50, 574-582.e3
32. Ouellet-Morin I, Odgers CL, Danese A, Bowes L, Shakoor S, Papadopoulos AS, Caspi A, Moffitt TE, Arseneault L (2011b). Blunted cortisol responses to stress signal social and behavioral problems among maltreated/bullied 12-year-old children. Biological Psychiatry 70, 1016-1023
33. Ouellet-Morin I, Wong CC, Danese A, Pariante CM, Papadopoulos AS, Mill J, Arseneault L (2013). Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins. Psychological Medicine 43, 1813-1823
34. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO III, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith Jr SC, Taubert K, Tracy RP, Vinicor F (2003). Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107, 499-511
35. Power C, Elliott J (2006). Cohort profile: 1958 British birth cohort (National Child Development Study). International Journal of Epidemiology 35, 34-41
36. Power C, Thomas C, Li L, Hertzman C (2012). Childhood psychosocial adversity and adult cortisol patterns. British Journal of Psychiatry 201, 199-206
37. Qualter P, Murphy SM, Abbott J, Gardner KJ, Japel C, Vitaro F, Boivin M, Tremblay RE (2015). Developmental associations between victimization and body mass index from 3 to 10 years in a population sample. Aggressive Behavior. Published online 14 January 2015. doi:10.1002/AB.21580
38. Ronning JA, Sourander A, Kumpulainen K, Tamminen T, Niemela S, Moilanen I, Helenius H, Piha J, Almqvist F (2009). Cross-informant agreement about bullying and victimization among eight-year-olds: whose information best predicts psychiatric caseness 10-15 years later? Social Psychiatry and Psychiatric Epidemiology 44, 15-22
39. Rosenman S, Rodgers B (2004). Childhood adversity in an Australian population. Social Psychiatry and Psychiatric Epidemiology 39, 695-702
40. Salmon G, James A, Smith DM (1998). Bullying in schools: self reported anxiety, depression, and self esteem in secondary school children. BMJ 317, 924-925
41. Schreier A, Wolke D, Thomas K, Horwood J, Hollis C, Gunnell D, Lewis G, Thompson A, Zammit S, Duffy L, Salvi G, Harrison G (2009). Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Archives of General Psychiatry 66, 527-536
42. Seaman SR, White IR (2013). Review of inverse probability weighting for dealing with missing data. Statistical Methods in Medical Research 22, 278-295
43. Shakoor S, Jaffee SR, Andreou P, Bowes L, Ambler AP, Caspi A, Moffitt TE, Arseneault L (2011). Mothers and children as informants of bullying victimization: results from an epidemiological cohort of children. Journal of Abnormal Child Psychology 39, 379-387
44. Shonkoff JP, Boyce WT, McEwen BS (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. Journal of the American Medical Association 301, 2252-2259
45. Singh GM, Danaei G, Farzadfar F, Stevens GA, Woodward M, Wormser D, Kaptoge S, Whitlock G, Qiao Q, Lewington S, Di Angelantonio E, Vander Hoorn S, Lawes CM, Ali MK, Mozaffarian D, Ezzati M (2013). The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis. PLOS ONE 8, e65174
46. Stott DH (1969). The Social Adjustment of Children. University of London Press: London
47. Takizawa R, Maughan B, Arseneault L (2014). Adult health outcomes of childhood bullying victimization: evidence from a five-decade longitudinal British birth cohort. American Journal of Psychiatry 171, 777-784
48. van Geel M, Vedder P, Tanilon J (2014). Relationship between peer victimization, cyberbullying, and suicide in children and adolescents: a meta-analysis. JAMA Pediatrics 168, 435-442
49. WhitlockG,LewingtonS,SherlikerP,ClarkeR,EmbersonJ, HalseyJ,QizilbashN,CollinsR,PetoR(2009).Body-mass indexandcause-specificmortalityin900000adults: collaborativeanalysesof57prospectivestudies.Lancet373, 1083-1096
50. Wienke Totura CM, Green AE, Karver MS, Gesten EL (2009). Multiple informants in the assessment of psychological, behavioral, and academic correlates of bullying and victimization in middle school. Journal of Adolescence 32, 193-211
51. Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A, Sarwar N, Kizer JR, Lawlor DA, Nordestgaard BG, Ridker P, Salomaa V, Stevens J, Woodward M, Sattar N, Collins R, Thompson SG, Whitlock G, Danesh J (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Lancet 377, 1085-1095