Poorer Drinking Outcomes with Citalopram Treatment for Alcohol Dependence: A Randomized, Double-Blind, Placebo-Controlled Trial

Alcoholism: Clinical and Experimental Research

Volumn 39, Issue 9, 2015, Pages 1756-1765

  Charney, Dara A ^a,b   Heath, Laura M ^a   Zikos, Eugenia ^b   Palacios Boix, Jorge ^a,b   Gill, Kathryn J ^a,b  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Alcohol Dependence; Citalopram; Depression; Selective Serotonin Reuptake Inhibitors; Treatment Outcome

Indexed keywords

ALCOHOL; CITALOPRAM; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

ADULT; ALCOHOL ABSTINENCE; ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DETOXIFICATION; DISTRESS SYNDROME; DOUBLE BLIND PROCEDURE; DRINKING BEHAVIOR; DRUG DOSE INCREASE; FAMILY HISTORY; FEMALE; FOLLOW UP; GROUP THERAPY; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MARRIAGE; MENTAL PATIENT; PERSONALITY DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; TELEPHONE INTERVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; AGED; MIDDLE AGED;

ADULT; AGED; ALCOHOLISM; CITALOPRAM; DEPRESSION; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 84941187775     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12802     Document Type: Article

References (50)

1. Alterman AI, Brown LS, Zaballero A, McKay JR (1994) Interviewer severity ratings and composite scores of the ASI - a further look. Drug Alcohol Depend 34:201-209.
2. Balldin J, Berggren U, Engel J, Eriksson M, Hård E, Söderpalm B (1994) Effect of citalopram on alcohol intake in heavy drinkers. Alcohol Clin Exp Res 18:1133-1136.
3. Barratt ES, Patton JH (1983) Impulsivity: cognitive, behavioral, and psychophysiological correlates, in Biological Basis of Sensation-Seeking, Impulsivity and Anxiety (Zuckerman M ed), pp 77-116. Lawrence Erlbaum Associates, Hillsdale, NJ.
4. Beck AT, Steer RA (1987) Beck Depression Inventory. Harcourt Brace, New York, NY.
5. Beck AT, Steer RA (1993) Beck Anxiety Inventory Manual. The Psychological Corporation Harcourt Brace & Company, San Antonio, TX.
6. Brookwell L, Hogan C, Healy D, Mangin D (2014) Ninety-three cases of alcohol dependence following SSRI treatment. Int J Risk Saf Med 26:99-107.
7. Charney DA, Palacios-Boix J, Negrete JC, Dobkin PL, Gill KJ (2005) Association between concurrent depression and anxiety and six-month outcome of addiction treatment. Psychiatr Serv 56:927-933.
8. Chick J, Aschauer H, Hornik K (2004) Efficacy of fluvoxamine in preventing relapse in alcohol dependence: a one-year, double-blind, placebo-controlled multicenter study with analysis by typology. Drug Alcohol Depend 74:61-70.
9. Cipriani A, Purgato M, Furukawa TA, Trespidi C, Imperadore G, Signoretti A, Churchill R, Watanabe N, Barbui C (2012) Citalopram versus other anti-depressive agents for depression. Cochrane Database Syst Rev (7):CD006534.
10. Cornelius JR, Salloum IM, Ehler JG, Jarrett PJ, Cornelius MD, Perel JM, Thase ME, Black A (1997) Fluoxetine in depressed alcoholics. A double-blind, placebo-controlled trial. Arch Gen Psychiatry 54:700-705.
11. Cornelius JR, Salloum IM, Haskett RF, Daley DC, Cornelius MD, Thase ME, Perel JM (2000) Fluoxetine versus placebo in depressed alcoholics: a 1-year follow-up study. Addict Behav 25:307-310.
12. Cronbach LJ (1951) Coefficient alpha and the internal structure of tests. Psychometrika 16:297-334.
13. Derogatis L (1992) Symptom Checklist - 90 (Revised): Administration, Scoring and Procedures Manual II. Clinical Psychometrics Research, Baltimore, MD.
14. Driessen M, Meier S, Hill A, Wetterling T, Lange W, Junghanns K (2001) The course of anxiety, depression and drinking behaviours after completed detoxification in alcoholics with and without comorbid anxiety and depressive disorders. Alcohol Alcohol 36:249-255.
15. Dundon W, Lynch KG, Pettinati HM, Lipkin C (2004) Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy. Alcohol Clin Exp Res 28:1065-1073.
16. Fahlke C, Berggren U, Berglund KJ, Zetterberg H, Blennow K, Engel JA, Balldin J (2012) Neuroendocrine assessment of serotonergic, dopaminergic, and noradrenergic functions in alcohol-dependent individuals. Alcohol Clin Exp Res 36:97-103.
17. First MB, Gibbon M, Spitzer RL, Williams JBW, Benjamin LS (1997) User's Guide for the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II). American Psychiatric Press, Washington, DC.
18. First MB, Spitzer RL, Gibbon M, Williams JBW (1996) Structured Clinical Interview for DSM-IV Axis I Disorders - Patient Edition (SCID-I/P, Verion 2.0). Biometrics Research Department, New York Psychiatric Institute, New York, NY.
19. Gerra G, Caccavari R, Delsignore R, Bocchi R, Fertonani G, Passeri M (1992) Effects of fluoxetine and Ca-acetyl-homotaurinate on alcohol intake in familial and nonfamilial alcoholic patients. Curr Ther Res 52:291-295.
20. Gill K, Amit Z, Koe BK (1988) Treatment with sertraline, a new serotonin uptake inhibitor, reduces voluntary ethanol consumption in rats. Alcohol 5:349-354.
21. Ginsburg B, Koek W, Javors MA, Lamb RJ (2005) Effects of fluvoxamine on a multiple schedule of ethanol- and food-maintained behavior in two rat strains. Psychopharmacology 180:249-257.
22. Gorelick DA (1989) Serotonin uptake blockers and the treatment of alcoholism, in Recent Developments in Alcoholism (Galanter M ed), pp 267-281. Springer US, New York, NY.
23. Greenfield SF, Weiss RD, Muenz LR, Vagge LM, Kelly JF, Bello LR, Michael J (1998) The effect of depression on return to drinking: a prospective study. Arch Gen Psychiatry 55:259-265.
24. Gual A, Balcells M, Torres M, Madrigal M, Diez T, Serrano L (2003) Sertraline for the prevention of relapse in detoxicated alcohol dependent patients with a comorbid depressive disorder: a randomized controlled trial. Alcohol Alcohol 38:619-625.
25. Hallgren KA, Witkiewitz K (2013) Missing data in alcohol clinical trials: a comparison of methods. Alcohol Clin Exp Res 37:2152-2160.
26. Hasin DS, Tsai WY, Endicott J, Mueller TI, Coryell W, Keller M (1996) Five-year course of major depression: effects of comorbid alcoholism. J Affect Disord 41:63-70.
27. Kabel DI, Petty F (1996) A placebo-controlled, double-blind study of fluoxetine in severe alcohol dependence: adjunctive pharmacotherapy during and after inpatient treatment. Alcohol Clin Exp Res 20:780-784.
28. Kranzler HR, Armeli S, Tennen H (2012) Post-treatment outcomes in a double-blind, randomized trial of sertraline for alcohol dependence. Alcohol Clin Exp Res 36:739-744.
29. Kranzler HR, Burleson JA, Korner P, Del Boca FK, Bohn MJ, Brown J, Liebowitz N (1995) Placebo-controlled trial of fluoxetine as an adjunct to relapse prevention in alcoholics. Am J Psychiat 152:391-397.
30. Kranzler HR, Del Boca FK, Rounsaville BJ (1996) Comorbid psychiatric diagnosis predicts three-year outcomes in alcoholics: a posttreatment natural history study. J Stud Alcohol 57:619-626.
31. Kranzler HR, Mueller T, Cornelius J, Pettinati HM, Moak D, Martin PR, Anthenelli R, Brower KJ, O'Malley S, Mason BJ, Hasin D, Keller M (2006) Sertraline treatment of co-occurring alcohol dependence and major depression. J Clin Psychopharmacol 26:13-20.
32. Little RJA (1998) A test of missing completely at random for multivariate data with missing values. J Am Stat Assoc 83:1198-1202.
33. McLellan AT, Randall M, Joseph N, Alterman AI (1990) Categorizing substance abusers using the ASI: implications for evaluation and treatment, in Research Monograph 105, Problems of Drug Dependence 1990: Proceeding of the 52nd Annual Scientific Meeting: The Committee on Problems of Drug Dependence, Inc., Symposium VIII, Diagnosing Substance Abuse and Dependence and Other Psychiatric Disorders (Harris L ed), pp 227-235. National Institute on Drug Abuse, Rockville, MD.
34. Miller WR, Rollnick S (1991) Motivational Interviewing: Preparing People to Change Addictive Behavior. Guilford Press, New York, NY.
35. Moak DH, Anton RF, Latham PK, Voronin KE, Waid RL, Durazo-Arvizu R (2003) Sertraline and cognitive behavioral therapy for depressed alcoholics: results of a placebo-controlled trial. J Clin Psychopharmacol 23:553-562.
36. Muhonen L, Lahti J, Sinclar D, Lönnqvist J, Alho H (2008a) Treatment of alcohol dependence in patients with co-morbid major depressive disorder - predictors for the outcomes with memantine and escitalopram medication. Subst Abuse Treat Prev Policy 3:20.
37. Naranjo CA, Knoke DM (2001) The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin Psychiatry 62(Suppl 20):18-25.
38. Naranjo CA, Knoke DM, Bremner KE (2000) Variations in response to citalopram in men and women with alcohol dependence. J Psychiatry Neurosci 25:269-275.
39. Naranjo CA, Sellers EM, Sullivan JT, Woodley DV, Kadlec K, Sykora K (1987) The serotonin uptake inhibitor citalopram attenuates ethanol intake. Clin Pharmacol Ther 41:266-274.
40. Oliveto A, Poling J, Mancino MJ, Williams K, Thostenson J, Pruzinsky R, Gonsai K, Sofuoglu M, Gonzalez G, Tripathi S, Kosten TR (2012) Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms. Addiction 107:131-141.
41. Pettinati HM, O'Brien CP, Dundon WD (2013) Current status of co-occurring mood and substance use disorders: a new therapeutic target. Am J Psychiat 170:23-30.
42. Pettinati HM, Volpicelli JR, Kranzler HR, Luck G, Rukstalis MR, Cnaan A (2000) Sertraline treatment for alcohol dependence: interactive effects of medication and alcoholic subtype. Alcohol Clin Exp Res 24:1041-1049.
43. Pettinati HM, Volpicelli JR, Luck G, Kranzler HR, Rukstalis MR, Cnaan A (2001) Double-blind clinical trial of sertraline treatment for alcohol dependence. J Clin Psychopharmacol 21:143-153.
44. StataCorp (2013) Stata: Release 13. Statistical Software. StataCorp LP, College Station, TX.
45. Tiihonen J, Ryynänen OP, Kauhanen J, Hakola HP, Salaspuro M (1996) Citalopram in the treatment of alcoholism: a double-blind placebo-controlled study. Pharmacopsychiatry 29:27-29.
46. Verheul R, Kranzler HR, Poling J, Tennen H, Ball S, Rounsaville BJ (2000) Axis I and Axis II disorders in alcoholics and drug addicts: fact or artifact? J Stud Alcohol 61:101-110.
47. Verrico CD, Haile CN, Mahoney JJ III, Thompson-Lake DGY, Newton TF, De La Garza R II (2014) Treatment with modafinil and escitalopram, alone and in combination, on cocaine-induced effects: a randomized, double blind, placebo-controlled human laboratory study. Drug Alcohol Depend 141:72-78.
48. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880.
49. Von Hippel PT (2009) How to impute squares, interactions, and other transformed variables. Sociol Methodol 39:265-291.
50. Winstanley EL, Bigelow GE, Silverman K, Johnson RE, Strain EC (2011) A randomized controlled trial of fluoxetine in the treatment of cocaine dependence among methadone-maintained patients. J Subst Abuse Treat 40:255-264.