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Volumn 33, Issue 9, 2015, Pages 952-961

Massively parallel high-order combinatorial genetics in human cells

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CELLS; CHEMOTHERAPY; CHROMOSOMES; COMPLEX NETWORKS; CYTOLOGY; DISEASES; LIBRARIES; THROUGHPUT;

EID: 84941116401     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3326     Document Type: Article
Times cited : (48)

References (61)
  • 2
    • 84866780162 scopus 로고    scopus 로고
    • Molecular roadblocks for cellular reprogramming
    • Vierbuchen, T., Wernig, M. Molecular roadblocks for cellular reprogramming. Mol. Cell 47, 827-838 (2012).
    • (2012) Mol. Cell , vol.47 , pp. 827-838
    • Vierbuchen, T.1    Wernig, M.2
  • 3
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani, B., Banerji, U., Workman, P. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol. 30, 679-692 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 4
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: Genetic interactions create phantom heritability
    • Zuk, O., Hechter, E., Sunyaev, S.R., Lander, E.S. The mystery of missing heritability: Genetic interactions create phantom heritability. Proc. Natl. Acad. Sci. USA 109, 1193-1198 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3    Lander, E.S.4
  • 5
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • Eichler, E.E. et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nat. Rev. Genet. 11, 446-450 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 446-450
    • Eichler, E.E.1
  • 6
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T.A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 7
    • 84889606709 scopus 로고    scopus 로고
    • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
    • Johannessen, C.M. et al. A melanocyte lineage program confers resistance to MAP kinase pathway inhibition. Nature 504, 138-142 (2013).
    • (2013) Nature , vol.504 , pp. 138-142
    • Johannessen, C.M.1
  • 8
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve, P.M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181 (2006).
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1
  • 9
    • 33644519040 scopus 로고    scopus 로고
    • Building mammalian signaling pathways with RNAi screens
    • Moffat, J., Sabatini, D.M. Building mammalian signaling pathways with RNAi screens. Nat. Rev. Mol. Cell Biol. 7, 177-187 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 177-187
    • Moffat, J.1    Sabatini, D.M.2
  • 10
    • 84900861730 scopus 로고    scopus 로고
    • High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells
    • Zhou, Y. et al. High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells. Nature 509, 487-491 (2014).
    • (2014) Nature , vol.509 , pp. 487-491
    • Zhou, Y.1
  • 11
    • 84898665052 scopus 로고    scopus 로고
    • Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
    • Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, M.D.C., Yusa, K. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat. Biotechnol. 32, 267-273 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 267-273
    • Koike-Yusa, H.1    Li, Y.2    Tan, E.-P.3    Velasco-Herrera, M.D.C.4    Yusa, K.5
  • 12
    • 84892765883 scopus 로고    scopus 로고
    • Genome-scale CRISPR-Cas9 knockout screening in human cells
    • Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
    • (2014) Science , vol.343 , pp. 84-87
    • Shalem, O.1
  • 13
    • 84892749369 scopus 로고    scopus 로고
    • Genetic screens in human cells using the CRISPR-Cas9 system
    • Wang, T., Wei, J.J., Sabatini, D.M., Lander, E.S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80-84 (2014).
    • (2014) Science , vol.343 , pp. 80-84
    • Wang, T.1    Wei, J.J.2    Sabatini, D.M.3    Lander, E.S.4
  • 14
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies - The next generation
    • Metzker, M.L. Sequencing technologies-the next generation. Nat. Rev. Genet. 11, 31-46 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 15
    • 79957874673 scopus 로고    scopus 로고
    • Next-generation sequencing to generate interactome datasets
    • Yu, H. et al. Next-generation sequencing to generate interactome datasets. Nat. Methods 8, 478-480 (2011).
    • (2011) Nat. Methods , vol.8 , pp. 478-480
    • Yu, H.1
  • 16
    • 84874113985 scopus 로고    scopus 로고
    • A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
    • Bassik, M.C. et al. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell 152, 909-922 (2013).
    • (2013) Cell , vol.152 , pp. 909-922
    • Bassik, M.C.1
  • 17
    • 56649114274 scopus 로고    scopus 로고
    • A one pot, one step, precision cloning method with high throughput capability
    • Engler, C., Kandzia, R., Marillonnet, S. A one pot, one step, precision cloning method with high throughput capability. PLoS ONE 3, e3647 (2008).
    • (2008) PLoS ONE , vol.3 , pp. e3647
    • Engler, C.1    Kandzia, R.2    Marillonnet, S.3
  • 18
    • 67349270900 scopus 로고    scopus 로고
    • Enzymatic assembly of DNA molecules up to several hundred kilobases
    • Gibson, D.G. et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6, 343-345 (2009).
    • (2009) Nat. Methods , vol.6 , pp. 343-345
    • Gibson, D.G.1
  • 19
    • 84877292750 scopus 로고    scopus 로고
    • Spanning high-dimensional expression space using ribosome-binding site combinatorics
    • Zelcbuch, L. et al. Spanning high-dimensional expression space using ribosome-binding site combinatorics. Nucleic Acids Res. 41, e98 (2013).
    • (2013) Nucleic Acids Res , vol.41 , pp. e98
    • Zelcbuch, L.1
  • 20
    • 80051684096 scopus 로고    scopus 로고
    • MicroRNA-mediated conversion of human fibroblasts to neurons
    • Yoo, A.S. et al. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476, 228-231 (2011).
    • (2011) Nature , vol.476 , pp. 228-231
    • Yoo, A.S.1
  • 21
    • 67651087321 scopus 로고    scopus 로고
    • Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications
    • Brown, B.D., Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat. Rev. Genet. 10, 578-585 (2009).
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 578-585
    • Brown, B.D.1    Naldini, L.2
  • 22
    • 51349110400 scopus 로고    scopus 로고
    • RPN2 gene confers docetaxel resistance in breast cancer
    • Honma, K. et al. RPN2 gene confers docetaxel resistance in breast cancer. Nat. Med. 14, 939-948 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 939-948
    • Honma, K.1
  • 23
    • 78149473552 scopus 로고    scopus 로고
    • Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
    • Creighton, C.J. et al. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 12, R40 (2010).
    • (2010) Breast Cancer Res , vol.12 , pp. R40
    • Creighton, C.J.1
  • 24
    • 34250697605 scopus 로고    scopus 로고
    • MicroRNA expression profiles for the NCI-60 cancer cell panel
    • Blower, P.E. et al. MicroRNA expression profiles for the NCI-60 cancer cell panel. Mol. Cancer Ther. 6, 1483-1491 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1483-1491
    • Blower, P.E.1
  • 25
    • 84870334293 scopus 로고    scopus 로고
    • Expression of microRNAs in the NCI-60 cancer cell-lines
    • Patnaik, S.K. et al. Expression of microRNAs in the NCI-60 cancer cell-lines. PLoS ONE 7, e49918 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e49918
    • Patnaik, S.K.1
  • 26
    • 84881613658 scopus 로고    scopus 로고
    • Global proteome analysis of the NCI-60 cell line panel
    • Gholami, A.M. et al. Global proteome analysis of the NCI-60 cell line panel. Cell Reports 4, 609-620 (2013).
    • (2013) Cell Reports , vol.4 , pp. 609-620
    • Gholami, A.M.1
  • 27
    • 84891796290 scopus 로고    scopus 로고
    • MiRTarBase update 2014: An information resource for experimentally validated miRNA-target interactions
    • Hsu, S.-D. et al. MiRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. Nucleic Acids Res. 42, D78-D85 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. D78-D85
    • Hsu, S.-D.1
  • 28
    • 84864755778 scopus 로고    scopus 로고
    • Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens
    • Strezoska, Ž. et al. Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens. PLoS ONE 7, e42341 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e42341
    • Strezoska, Ž.1
  • 29
    • 71549167606 scopus 로고    scopus 로고
    • MIR-15a and MIR-16 control Bmi-1 expression in ovarian cancer
    • Bhattacharya, R. et al. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res. 69, 9090-9095 (2009).
    • (2009) Cancer Res , vol.69 , pp. 9090-9095
    • Bhattacharya, R.1
  • 30
    • 84906678385 scopus 로고    scopus 로고
    • Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics
    • Cheng, A.A., Ding, H., Lu, T.K. Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics. Proc. Natl. Acad. Sci. USA 111, 12462-12467 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 12462-12467
    • Cheng, A.A.1    Ding, H.2    Lu, T.K.3
  • 31
    • 84879319702 scopus 로고    scopus 로고
    • Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells
    • Kampmann, M., Bassik, M.C., Weissman, J.S. Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proc. Natl. Acad. Sci. USA 110, E2317-E2326 (2013).
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. E2317-E2326
    • Kampmann, M.1    Bassik, M.C.2    Weissman, J.S.3
  • 32
    • 39149125171 scopus 로고    scopus 로고
    • Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures
    • Pierce, S.E., Davis, R.W., Nislow, C., Giaever, G. Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures. Nat. Protoc. 2, 2958-2974 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 2958-2974
    • Pierce, S.E.1    Davis, R.W.2    Nislow, C.3    Giaever, G.4
  • 33
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • Storey, J.D., Tibshirani, R. Statistical significance for genomewide studies. Proc. Natl. Acad. Sci. USA 100, 9440-9445 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2
  • 34
    • 44949249814 scopus 로고    scopus 로고
    • MIR-15b and MIR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells
    • Xia, L. et al. miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells. Int. J. Cancer 123, 372-379 (2008).
    • (2008) Int. J. Cancer , vol.123 , pp. 372-379
    • Xia, L.1
  • 35
    • 84856231030 scopus 로고    scopus 로고
    • MiRNA-34a is associated with docetaxel resistance in human breast cancer cells
    • Kastl, L., Brown, I., Schofield, A.C. MiRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer Res. Treat. 131, 445-454 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.131 , pp. 445-454
    • Kastl, L.1    Brown, I.2    Schofield, A.C.3
  • 36
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • Krek, A. et al. Combinatorial microRNA target predictions. Nat. Genet. 37, 495-500 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 495-500
    • Krek, A.1
  • 37
    • 84887499256 scopus 로고    scopus 로고
    • Analysis of microRNA-target interactions across diverse cancer types
    • Jacobsen, A. et al. Analysis of microRNA-target interactions across diverse cancer types. Nat. Struct. Mol. Biol. 20, 1325-1332 (2013).
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 1325-1332
    • Jacobsen, A.1
  • 38
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis, B.P., Burge, C.B., Bartel, D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005).
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 39
    • 84859772362 scopus 로고    scopus 로고
    • Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
    • Guillamot, M. et al. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription. Sci. Rep. 1, 189 (2011).
    • (2011) Sci. Rep. , vol.1 , pp. 189
    • Guillamot, M.1
  • 40
    • 78751477191 scopus 로고    scopus 로고
    • Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
    • Huntzinger, E., Izaurralde, E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nat. Rev. Genet. 12, 99-110 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 99-110
    • Huntzinger, E.1    Izaurralde, E.2
  • 41
    • 84908406633 scopus 로고    scopus 로고
    • Applying synthetic lethality for the selective targeting of cancer
    • McLornan, D.P., List, A., Mufti, G.J. Applying synthetic lethality for the selective targeting of cancer. N. Engl. J. Med. 371, 1725-1735 (2014).
    • (2014) N. Engl. J. Med. , vol.371 , pp. 1725-1735
    • McLornan, D.P.1    List, A.2    Mufti, G.J.3
  • 42
    • 84884994218 scopus 로고    scopus 로고
    • The Cancer Genome Atlas Pan-Cancer analysis project
    • The Cancer Genome Atlas Research Network et al
    • The Cancer Genome Atlas Research Network. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113-1120 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1113-1120
  • 43
    • 84897459814 scopus 로고    scopus 로고
    • An atlas of active enhancers across human cell types and tissues
    • Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455-461 (2014).
    • (2014) Nature , vol.507 , pp. 455-461
    • Andersson, R.1
  • 44
    • 84897406127 scopus 로고    scopus 로고
    • A promoter-level mammalian expression atlas
    • FANTOM Consortium and the RIKEN PMI and CLST (DGT)
    • FANTOM Consortium and the RIKEN PMI and CLST (DGT). A promoter-level mammalian expression atlas. Nature 507, 462-470 (2014).
    • (2014) Nature , vol.507 , pp. 462-470
  • 45
    • 77954122221 scopus 로고    scopus 로고
    • Genome-wide association studies: The key to unlocking neurodegeneration
    • Gandhi, S., Wood, N.W. Genome-wide association studies: the key to unlocking neurodegeneration? Nat. Neurosci. 13, 789-794 (2010).
    • (2010) Nat. Neurosci. , vol.13 , pp. 789-794
    • Gandhi, S.1    Wood, N.W.2
  • 46
    • 84856061348 scopus 로고    scopus 로고
    • Thirty-five common variants for coronary artery disease: The fruits of much collaborative labour
    • Peden, J.F., Farrall, M. Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum. Mol. Genet. 20, R198-R205 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. R198-R205
    • Peden, J.F.1    Farrall, M.2
  • 47
    • 55749101028 scopus 로고    scopus 로고
    • A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene
    • Gobeil, S., Zhu, X., Doillon, C.J., Green, M.R. A genome-wide shRNA screen identifies GAS1 as a novel melanoma metastasis suppressor gene. Genes Dev. 22, 2932-2940 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2932-2940
    • Gobeil, S.1    Zhu, X.2    Doillon, C.J.3    Green, M.R.4
  • 48
    • 84879414055 scopus 로고    scopus 로고
    • RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
    • Park, J. et al. RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature 498, 325-331 (2013).
    • (2013) Nature , vol.498 , pp. 325-331
    • Park, J.1
  • 49
    • 78149465975 scopus 로고    scopus 로고
    • A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
    • Chia, N.-Y. et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 468, 316-320 (2010).
    • (2010) Nature , vol.468 , pp. 316-320
    • Chia, N.-Y.1
  • 50
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • Ebert, M.S., Neilson, J.R., Sharp, P.A. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 4, 721-726 (2007).
    • (2007) Nat. Methods , vol.4 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 51
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • Guttman, M. et al. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477, 295-300 (2011).
    • (2011) Nature , vol.477 , pp. 295-300
    • Guttman, M.1
  • 52
    • 84908352138 scopus 로고    scopus 로고
    • Genome-scale CRISPR-mediated control of gene repression and activation
    • Gilbert, L.A. et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159, 647-661 (2014).
    • (2014) Cell , vol.159 , pp. 647-661
    • Gilbert, L.A.1
  • 53
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu, P.D., Lander, E.S., Zhang, F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 157, 1262-1278 (2014).
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1    Lander, E.S.2    Zhang, F.3
  • 54
    • 84879264708 scopus 로고    scopus 로고
    • ZFN TALEN, and CRISPR/Cas-based methods for genome engineering
    • Gaj, T., Gersbach, C.A., Barbas, C.F. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31, 397-405 (2013).
    • (2013) Trends Biotechnol , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 55
    • 84898990861 scopus 로고    scopus 로고
    • DICE, an efficient system for iterative genomic editing in human pluripotent stem cells
    • Zhu, F. et al. DICE, an efficient system for iterative genomic editing in human pluripotent stem cells. Nucleic Acids Res. 42, e34 (2014).
    • (2014) Nucleic Acids Res , vol.42 , pp. e34
    • Zhu, F.1
  • 56
    • 79955964537 scopus 로고    scopus 로고
    • Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay
    • Bruno, I.G. et al. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol. Cell 42, 500-510 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 500-510
    • Bruno, I.G.1
  • 57
    • 36448969801 scopus 로고    scopus 로고
    • Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
    • Klein, M.E. et al. Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat. Neurosci. 10, 1513-1514 (2007).
    • (2007) Nat. Neurosci. , vol.10 , pp. 1513-1514
    • Klein, M.E.1
  • 58
    • 79953803779 scopus 로고    scopus 로고
    • Cortical representations of olfactory input by trans-synaptic tracing
    • Miyamichi, K. et al. Cortical representations of olfactory input by trans-synaptic tracing. Nature 472, 191-196 (2011).
    • (2011) Nature , vol.472 , pp. 191-196
    • Miyamichi, K.1
  • 59
    • 84865131794 scopus 로고    scopus 로고
    • Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4
    • Ren, Y. et al. Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Sci. Transl. Med. 4, 147-112 (2012).
    • (2012) Sci. Transl. Med. , vol.4 , pp. 147-152
    • Ren, Y.1
  • 60
    • 33645124487 scopus 로고    scopus 로고
    • Derivation of genetic interaction networks from quantitative phenotype data
    • Drees, B.L. et al. Derivation of genetic interaction networks from quantitative phenotype data. Genome Biol. 6, R38 (2005).
    • (2005) Genome Biol , vol.6 , pp. R38
    • Drees, B.L.1
  • 61
    • 10744230485 scopus 로고    scopus 로고
    • Global mapping of the yeast genetic interaction network
    • Tong, A.H.Y. et al. Global mapping of the yeast genetic interaction network. Science 303, 808-813 (2004).
    • (2004) Science , vol.303 , pp. 808-813
    • Tong, A.H.Y.1


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