Effects of Postinfarct Myelin-Associated Glycoprotein Antibody Treatment on Motor Recovery and Motor Map Plasticity in Squirrel Monkeys

Stroke

Volumn 46, Issue 6, 2015, Pages 1620-1625

  Barbay, Scott ^a   Plautz, Erik J ^a   Zoubina, Elena ^a   Frost, Shawn B ^a   Cramer, Steven C ^a   Nudo, Randolph J ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

FAM168B protein, human; haplorhini; neuronal plasticity; neurophysiology; recovery of function; stroke

Indexed keywords

MYELIN ASSOCIATED GLYCOPROTEIN; REFANEZUMAB; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BRAIN INFARCTION; BRAIN MAPPING; CONTROL GROUP; CONTROLLED STUDY; DRUG EFFICACY; FORELIMB; MALE; MOTOR CORTEX; MOTOR PERFORMANCE; MOVEMENT (PHYSIOLOGY); NERVE CELL PLASTICITY; NEUROPHYSIOLOGICAL MONITORING; NONHUMAN; PREMOTOR CORTEX; PRIMATE MODEL; PRIORITY JOURNAL; SQUIRREL MONKEY; TASK PERFORMANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CONVALESCENCE; DRUG EFFECTS; METABOLISM; NERVE FIBER; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; AXONS; BRAIN INFARCTION; MOTOR CORTEX; MOTOR SKILLS; MYELIN-ASSOCIATED GLYCOPROTEIN; RECOVERY OF FUNCTION; SAIMIRI;

EID: 84940990172     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.114.008088     Document Type: Article

References (24)

1. Adams HP Jr, Nudo RJ. Management of patients with stroke: is it time to expand treatment options Ann Neurol. 2013;74:4-10. doi: 10.1002/ana.23948.
2. Li S, Carmichael ST. Growth-associated gene and protein expression in the region of axonal sprouting in the aged brain after stroke. Neurobiol Dis. 2006;23:362-373. doi: 10.1016/j.nbd.2006.03.011.
3. Irving EA, Vinson M, Rosin C, Roberts JC, Chapman DM, Facci L, et al. Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke J Cereb Blood Flow Metab. 2005;25:98-107. doi: 10.1038/sj.jcbfm.9600011.
4. Nishibe M, Urban ET III, Barbay S, Nudo RJ. Rehabilitative training promotes motor recovery but delayed motor map reorganization in a rat cortical ischemic infarct model [published online ahead of print July 22, 2014]. Neurorehabil Neural Repair. http://nnr.sagepub.com/content/early/recent. Accessed April 3, 2015.
5. Frost SB, Barbay S, Friel KM, Plautz EJ, Nudo RJ. Reorganization of remote cortical regions after ischemic brain injury: a potential substrate for stroke recovery. J Neurophysiol. 2003;89:3205-3214. doi: 10.1152/jn.01143.2002.
6. Urban ET III, Bury SD, Barbay HS, Guggenmos DJ, Dong Y, Nudo RJ. Gene expression changes of interconnected spared cortical neurons 7 days after ischemic infarct of the primary motor cortex in the rat. Mol Cell Biochem. 2012;369:267-286. doi: 10.1007/s11010-012-1390-z.
7. Overman JJ, Clarkson AN, Wanner IB, Overman WT, Eckstein I, Maguire JL, et al. A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke. Proc Natl Acad Sci USA. 2012;109:E2230-E2239. doi: 10.1073/pnas.1204386109.
8. Dancause N, Barbay S, Frost SB, Zoubina EV, Plautz EJ, Mahnken JD, et al. Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex. J Neurophysiol. 2006;96:3506-3511. doi: 10.1152/jn.00792.2006.
9. Hinman JD, Rasband MN, Carmichael ST. Remodeling of the axon initial segment after focal cortical and white matter stroke. Stroke. 2013;44:182-189. doi: 10.1161/STROKEAHA.112.668749.
10. Thompson HJ, Marklund N, LeBold DG, Morales DM, Keck CA, Vinson M, et al. Tissue sparing and functional recovery following experimental traumatic brain injury is provided by treatment with an anti-myelin-associated glycoprotein antibody. Eur J Neurosci. 2006;24:3063-3072. doi:10.1111/j.1460-9568.2006.05197.x.
11. Abila B, Cunningham E, Simeoni M. First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers. Clin Pharmacol Ther. 2013;93:163-169. doi: 10.1038/clpt.2012.227.
12. Cramer SC, Abila B, Scott NE, Simeoni M, Enney LA; MAG111539 Study Investigators. Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke. Stroke. 2013;44:1337-1342. doi: 10.1161/STROKEAHA.111.674366.
13. Nudo RJ, Jenkins WM, Merzenich MM, Prejean T, Grenda R. Neurophysiological correlates of hand preference in primary motor cortex of adult squirrel monkeys. J Neurosci. 1992;12:2918-2947.
14. Schwab ME, Strittmatter SM. Nogo limits neural plasticity and recovery from injury. Curr Opin Neurobiol. 2014;27:53-60. doi: 10.1016/j. conb.2014.02.011.
15. Fang PC, Barbay S, Plautz EJ, Hoover E, Strittmatter SM, Nudo RJ. Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats. Stroke. 2010;41:544-549. doi: 10.1161/STROKEAHA.109.572073.
16. Lee JK, Kim JE, Sivula M, Strittmatter SM. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity. J Neurosci. 2004;24:6209-6217. doi: 10.1523/JNEUROSCI.1643-04.2004.
17. Arai K, Lo EH. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009;1:6. doi:10.1186/2040-7378-1-6.
18. Mifsud G, Zammit C, Muscat R, Di Giovanni G, Valentino M. Oligodendrocyte pathophysiology and treatment strategies in cerebral ischemia. CNS Neurosci Ther. 2014;20:603-612. doi: 10.1111/cns.12263.
19. Akbik F, Cafferty WB, Strittmatter SM. Myelin associated inhibitors: a link between injury-induced and experience-dependent plasticity. Exp Neurol. 2012;235:43-52. doi: 10.1016/j.expneurol.2011.06.006.
20. Raiker SJ, Lee H, Baldwin KT, Duan Y, Shrager P, Giger RJ. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. J Neurosci. 2010;30:12432-12445. doi: 10.1523/JNEUROSCI.0895-10.2010.
21. Eisner-Janowicz I, Barbay S, Hoover E, Stowe AM, Frost SB, Plautz EJ, et al. Early and late changes in the distal forelimb representation of the supplementary motor area after injury to frontal motor areas in the squirrel monkey. J Neurophysiol. 2008;100:1498-1512. doi: 10.1152/jn.90447.2008.
22. Plautz EJ, Barbay S, Frost SB, Dancause N, Stowe AM, Zoubina EV, et al. Injury-Induced Reduction and Recovery of Hand Area Representation in Ventral Premotor Cortex Following Ischemic Infarct in Primary Motor Cortex. "Abstract". Program No. 878.8, 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience; 2004.
23. Friel KM, Nudo RJ. Recovery of motor function after focal cortical injury in primates: compensatory movement patterns used during rehabilitative training. Somatosens Mot Res. 1998;15:173-189.
24. Davare M, Andres M, Cosnard G, Thonnard JL, Olivier E. Dissociating the role of ventral and dorsal premotor cortex in precision grasping. J Neurosci. 2006;26:2260-2268. doi: 10.1523/JNEUROSCI.3386-05.2006.