Liraglutide activates AMPK signaling and partially restores normal circadian rhythm and insulin secretion in pancreatic islets in diabetic mice

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 8, 2015, Pages 1142-1149

  Wang, Kexin ^a   Sun, Yu ^a   Lin, Peng ^a   Song, Jun ^a   Zhao, Ruxing ^a   Li, Wenjuan ^a   Hou, Xinguo ^a   Wang, Chuan ^a   Wang, Lingshu ^a   Zhu, Ping ^c   Chen, Li ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

5 AMP activated protein kinase (AMPK); Circadian clock; Glucagon like peptide 1 (GLP 1); cell function

Indexed keywords

ADENYLATE KINASE; GLUCAGON LIKE PEPTIDE 1; LIRAGLUTIDE; ANTIDIABETIC AGENT; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; HUMIDITY; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MALE; MICROSCOPY; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET CELL FUNCTION; PHENOTYPE; PROTEIN PHOSPHORYLATION; RADIOIMMUNOPRECIPITATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SECRETION (PROCESS);

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CIRCADIAN RHYTHM; DIABETES MELLITUS, EXPERIMENTAL; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GLUCOSE INTOLERANCE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIRAGLUTIDE; MALE; MICE, INBRED C57BL; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84940921725     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00024     Document Type: Article

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