Impact of Antipsychotic Treatment on Attention and Motor Learning Systems in First-Episode Schizophrenia

Schizophrenia Bulletin

Volumn 41, Issue 2, 2015, Pages 355-365

  Keedy, Sarah K ^a   Reilly, James L ^b   Bishop, Jeffrey R ^c   Weiden, Peter J ^c   Sweeney, John A ^d  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

caudate; cognition; dorsolateral prefrontal cortex; fMRI; risperidone; saccades

Indexed keywords

ARIPIPRAZOLE; NEUROLEPTIC AGENT; RISPERIDONE;

ADULT; ARTICLE; ATTENTION; BOLD SIGNAL; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DORSOLATERAL PREFRONTAL CORTEX; FEMALE; FIRST EPISODE SCHIZOPHRENIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAMILTON DEPRESSION RATING SCALE; HUMAN; INTELLIGENCE QUOTIENT; LEARNING; MALE; MOTOR PERFORMANCE; NEUROLOGIC DISEASE; OCCIPITAL CORTEX; POSITIVE AND NEGATIVE SYNDROME SCALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; SOCIAL STATUS; SUPERIOR TEMPORAL SULCUS; TASK PERFORMANCE; TEMPORAL CORTEX; YOUNG ADULT; CAUDATE NUCLEUS; DRUG EFFECTS; FOLLOW UP; MOTOR ACTIVITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; VISION;

ADULT; ANTIPSYCHOTIC AGENTS; ATTENTION; CAUDATE NUCLEUS; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEARNING; MAGNETIC RESONANCE IMAGING; MALE; MOTOR ACTIVITY; PREFRONTAL CORTEX; SCHIZOPHRENIA; VISUAL PERCEPTION; YOUNG ADULT;

EID: 84940884516     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbu071     Document Type: Article

References (57)

1. Gangadhar BN, Jayakumar PN, Subbakrishna DK, Janakiramaiah N, Keshavan MS. Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study. Am J Psychiatry. 2004;161:1304-1306.
2. Morey RA, Inan S, Mitchell TV, Perkins DO, Lieberman JA, Belger A. Imaging frontostriatal function in ultra-high-risk, early, and chronic schizophrenia during executive processing. Arch Gen Psychiatry. 2005;62:254-262.
3. Chudasama Y, Robbins TW. Functions of frontostriatal systems in cognition: comparative neuropsychopharmacological studies in rats, monkeys and humans. Biol Psychol. 2006;73:19-38.
4. Quan M, Lee SH, Kubicki M, et al. White matter tract abnormalities between rostral middle frontal gyrus, inferior frontal gyrus and striatum in first-episode schizophrenia. Schizophr Res. 2013;145:1-10.
5. Howes OD, Egerton A, Allan V, McGuire P, Stokes P, Kapur S. Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging. Curr Pharm Des. 2009;15:2550-2559.
6. Ginovart N, Kapur S. Role of dopamine D2 receptors for antipsychotic activity. In: Gross G, Geyer MA, eds. Current Antipsychotics. Vol 212. Heidelberg: Springer; 2012:27-52.
7. Chua SE, Deng Y, Chen EYH, et al. Early striatal hypertrophy in first-episode psychosis within 3 weeks of initiating antipsychotic drug treatment. Psychol Med. 2009;39:793-800.
8. Stone JM, Davis JM, Leucht S, Pilowsky LS. Cortical dopamine D2/D3 receptors are a common site of action for antipsychotic drugs-an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature. Schizophr Bull. 2009;35:789-797.
9. Agid O, Remington G, Kapur S, Arenovich T, Zipursky RB. Early use of clozapine for poorly responding first-episode psychosis. J Clin Psychopharmacol. 2007;27:369-373.
10. Keedy SK, Rosen C, Khine T, Rajarethinam R, Janicak PG, Sweeney JA. An fMRI study of visual attention and sensorimotor function before and after antipsychotic treatment in first-episode schizophrenia. Psychiatry Res. 2009;172:16-23.
11. Reilly JL, Harris MS, Keshavan MS, Sweeney JA. Adverse effects of risperidone on spatial working memory in first-episode schizophrenia. Arch Gen Psychiatry. 2006;63:1189-1197.
12. Harris MS, Wiseman CL, Reilly JL, Keshavan MS, Sweeney JA. Effects of risperidone on procedural learning in antipsychotic-naive first-episode schizophrenia. Neuropsychopharmacology. 2009;34:468-476.
13. Nielsen MØ, Rostrup E, Wulff S, et al. Alterations of the brain reward system in antipsychotic naïve schizophrenia patients. Biol Psychiatry. 2012;71:898-905.
14. Snitz BE, MacDonald A III, Cohen JD, Cho RY, Becker T, Carter CS. Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatment. Am J Psychiatry. 2005;162:2322-2329.
15. Sweeney JA, Mintun MA, Kwee S, et al. Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. J Neurophysiol. 1996;75:454-468.
16. Johnston K, Everling S. Neurophysiology and neuroanatomy of reflexive and voluntary saccades in non-human primates. Brain Cogn. 2008;68:271-283.
17. Simó LS, Krisky CM, Sweeney JA. Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems. Cereb Cortex. 2005;15:1982-1991.
18. McDowell JE, Dyckman KA, Austin BP, Clementz BA. Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans. Brain Cogn. 2008;68:255-270.
19. Reilly JL, Harris MS, Keshavan MS, Sweeney JA. Abnormalities in visually guided saccades suggest corticofugal dysregulation in never-treated schizophrenia. Biol Psychiatry. 2005;57:145-154.
20. Reilly JL, Harris MS, Khine TT, Keshavan MS, Sweeney JA. Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia. Biol Psychiatry. 2008;63:776-783.
21. Luna B, Thulborn KR, Strojwas MH, et al. Dorsal cortical regions subserving visually guided saccades in humans: an fMRI study. Cereb Cortex. 1998;8:40-47.
22. Ngan E, Lane C, Ruth T, Liddle P. Immediate and delayed effects of risperidone on cerebral metabolism in neuroleptic naive schizophrenic patients: correlations with symptom change. J Neurol Neurosurg Psychiatry. 2002;72:106-110.
23. Tan H-Y, Choo W-C, Fones CS, Chee MW. fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia. Am J Psychiatry. 2005;162:1849-1858.
24. First MB, Spitzer RL, Gibbon M, Williams JB. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. New York, NY: Biometrics Research, New York State Psychiatric Institute; 2002.
25. Wilkinson GS. The Wide Range Achievement Test: Manual. 3rd ed. Wilmington, DE: Wide Range; 1993.
26. Hollingshead AA. Four-factor Index of Social Status. New Haven, CT: Yale University; 1975.
27. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13:261-276.
28. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
29. Becker W. The neurobiology of saccadic eye movements. Metrics. Rev Oculomotor Res. 1989;3:13.
30. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996;29:162-173.
31. Keedy SK, Ebens CL, Keshavan MS, Sweeney JA. Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task. Psychiatry Res. 2006;146:199-211.
32. Andreasen NC, Pressler M, Nopoulos P, Miller D, Ho BC. Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs. Biol Psychiatry. 2010;67:255-262.
33. Sweeney JA, Keilp JG, Haas GL, Hill J, Weiden PJ. Relationships between medication treatments and neuropsychological test performance in schizophrenia. Psychiatry Res. 1991;37:297-308.
34. Seamans JK, Floresco SB, Phillips AG. D1 receptor modulation of hippocampal-prefrontal cortical circuits integrating spatial memory with executive functions in the rat. J Neurosci. 1998;18:1613-1621.
35. Rinaldi A, Mandillo S, Oliverio A, Mele A. D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Neuropsychopharmacology. 2007;32:309-319.
36. Burke MR, Barnes GR. Brain and behavior: a task-dependent eye movement study. Cereb Cortex. 2008;18:126-135.
37. Weidner R, Krummenacher J, Reimann B, Müller HJ, Fink GR. Sources of top-down control in visual search. J Cogn Neurosci. 2009;21:2100-2113.
38. Pollmann S, Weidner R, Müller HJ, Yves von Cramon D. Neural correlates of visual dimension weighting. Vis Cogn. 2006;14:877-897.
39. Merriam EP, Colby CL, Thulborn KR, Luna B, Olson CR, Sweeney JA. Stimulus-response incompatibility activates cortex proximate to three eye fields. Neuroimage. 2001;13:794-800.
40. Dyckman KA, Camchong J, Clementz BA, McDowell JE. An effect of context on saccade-related behavior and brain activity. Neuroimage. 2007;36:774-784.
41. Milea D, Lobel E, Lehéricy S, et al. Prefrontal cortex is involved in internal decision of forthcoming saccades. Neuroreport. 2007;18:1221-1224.
42. Lui S, Li T, Deng W, et al. Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by "resting state" functional magnetic resonance imaging. Arch Gen Psychiatry. 2010;67:783-792.
43. Armstrong KM, Fitzgerald JK, Moore T. Changes in visual receptive fields with microstimulation of frontal cortex. Neuron. 2006;50:791-798.
44. Gilbert CD, Sigman M. Brain states: top-down influences in sensory processing. Neuron. 2007;54:677-696.
45. Lencer R, Keedy SK, Reilly JL, et al. Altered transfer of visual motion information to parietal association cortex in untreated first-episode psychosis: implications for pursuit eye tracking. Psychiatry Res. 2011;194:30-38.
46. Braus DF, Weber-Fahr W, Tost H, Ruf M, Henn FA. Sensory information processing in neuroleptic-naive first-episode schizophrenic patients: a functional magnetic resonance imaging study. Arch Gen Psychiatry. 2002;59:696-701.
47. McDowell JE, Brown GG, Paulus M, et al. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biol Psychiatry. 2002;51:216-223.
48. Corson PW, O'Leary DS, Miller DD, Andreasen NC. The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: a comparison between the neuroleptic-naïve and medicated states. Biol Psychiatry. 2002;52:855-862.
49. Ertugrul A, Volkan-Salanci B, Basar K, et al. The effect of clozapine on regional cerebral blood flow and brain metabolite ratios in schizophrenia: relationship with treatment response. Psychiatry Res. 2009;174:121-129.
50. McDowell JE, Clementz BA, Wixted JT. Timing and amplitude of saccades during predictive saccadic tracking in schizophrenia. Psychophysiology. 1996;33:93-101.
51. Karoumi B, Ventre-Dominey J, Dalery J. Predictive saccade behavior is enhanced in schizophrenia. Cognition. 1998;68:B81-B91.
52. Spengler D, Trillenberg P, Sprenger A, et al. Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive-compulsive disorder. Psychiatry Res. 2006;143:77-88.
53. Abi-Dargham A, Xu X, Thompson JL, et al. Increased prefrontal cortical D1 receptors in drug naive patients with schizophrenia: a PET study with [11C]NNC112. J Psychopharmacol. 2012;26:794-805.
54. Crawford TJ, Haeger B, Kennard C, Reveley MA, Henderson L. Saccadic abnormalities in psychotic patients. II. The role of neuroleptic treatment. Psychol Med. 1995;25:473-483.
55. Hommer DW, Clem T, Litman R, Pickar D. Maladaptive anticipatory saccades in schizophrenia. Biol Psychiatry. 1991;30:779-794.
56. Reilly JL, Harris MS, Khine TT, Keshavan MS, Sweeney JA. Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia. Biol Psychiatry. 2007;62:818-821.
57. Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV. Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology (Berl). 2004;174:3-16.