Post-transplant persistent lymphopenia is a strong predictor of late survival in isolated intestine and multivisceral transplantation

Transplant International

Volumn 28, Issue 10, 2015, Pages 1195-1204

  Nagai, Shunji ^a   Mangus, Richard S ^a   Anderson, Eve ^a   Ekser, Burcin ^a   Kubal, Chandrashekhar A ^a   Burch, Tracy ^a   Fridell, Jonathan A ^a   Tector, A Joseph ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

absolute lymphocyte count; graft survival; infection; nutrition; patient survival

Indexed keywords

ABDOMINAL SURGERY; ADOLESCENT; ADULT; AGED; ARTICLE; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; FEMALE; GRAFT SURVIVAL; HUMAN; INTESTINE GRAFT; INTESTINE TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIVISCERAL TRANSPLANTATION; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROGNOSTIC ASSESSMENT; RISK FACTOR; SURVIVAL RATE; TREND STUDY; FOLLOW UP; INFECTION; INTESTINE; KAPLAN MEIER METHOD; LIVER TRANSPLANTATION; LYMPHOPENIA; MIDDLE AGED; MORTALITY; NONPARAMETRIC TEST; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; STOMACH; TRANSPLANTATION; VISCERA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HUMANS; INFECTION; INTESTINES; KAPLAN-MEIER ESTIMATE; LIVER TRANSPLANTATION; LYMPHOCYTE COUNT; LYMPHOPENIA; MALE; MIDDLE AGED; PANCREAS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; STOMACH; VISCERA; YOUNG ADULT;

EID: 84940797192     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12620     Document Type: Article

References (27)

1. Smith JM, Skeans MA, Horslen SP, et al,. OPTN/SRTR 2012 Annual Data Report: intestine. Am J Transplant 2014; 14 (Suppl 1): 97.
2. Israni AK, Skeans MA, Gustafson SK, et al,. OPTN/SRTR 2012 Annual Data Report: pancreas. Am J Transplant 2014; 14 (Suppl 1): 45.
3. Kim WR, Smith JM, Skeans MA, et al,. OPTN/SRTR 2012 Annual Data Report: liver. Am J Transplant 2014; 14 (Suppl 1): 69.
4. Matas AJ, Smith JM, Skeans MA, et al,. OPTN/SRTR 2012 Annual Data Report: kidney. Am J Transplant 2014; 14 (Suppl 1): 11.
5. Abu-Elmagd KM, Kosmach-Park B, Costa G, et al,. Long-term survival, nutritional autonomy, and quality of life after intestinal and multivisceral transplantation. Ann Surg 2012; 256: 494.
6. Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A,. Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care 2012; 16: R12.
7. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC,. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010; 14: R192.
8. Ray-Coquard I, Cropet C, Van Glabbeke M, et al,. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res 2009; 69: 5383.
9. O'Keefe SJ, El-Zayadi AR, Carraher TE, Davis M, Williams R,. Malnutrition and immuno-incompetence in patients with liver disease. Lancet 1980; 2: 615.
10. Nagai S, Yoshida A, Kohno K, et al,. Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation. Hepatology 2014; 59: 35.
11. Nagai S, Abouljoud MS, Kazimi M, Brown KA, Moonka D, Yoshida A,. Peritransplant lymphopenia is a novel prognostic factor in recurrence of hepatocellular carcinoma after liver transplantation. Transplantation 2014; 97: 694.
12. Fernández-Ruiz M, López-Medrano F, Romo EM, et al,. Pretransplant lymphocyte count predicts the incidence of infection during the first two years after liver transplantation. Liver Transpl 2009; 15: 1209.
13. Nierenberg NE, Poutsiaka DD, Chow JK, et al,. Pretransplant lymphopenia is a novel prognostic factor in cytomegalovirus and noncytomegalovirus invasive infections after liver transplantation. Liver Transpl 2014; 20: 1497.
14. Nozoe T, Ninomiya M, Maeda T, Matsukuma A, Nakashima H, Ezaki T,. Prognostic nutritional index: a tool to predict the biological aggressiveness of gastric carcinoma. Surg Today 2010; 40: 440.
15. Kanda M, Fujii T, Kodera Y, Nagai S, Takeda S, Nakao A,. Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg 2011; 98: 268.
16. Fridell JA, Joseph Tector A, Mangus RS, Kazimi MM, Hollinger EF, Vianna RM,. A new vascular approach to the modified multivisceral graft procurement. Clin Transplant 2009; 23: 784.
17. Abu-Elmagd K, Fung J, Bueno J, et al,. Logistics and technique for procurement of intestinal, pancreatic, and hepatic grafts from the same donor. Ann Surg 2000; 232: 680.
18. Vianna RM, Mangus RS, Kubal C, Fridell JA, Beduschi T, Tector AJ,. Multivisceral transplantation for diffuse portomesenteric thrombosis. Ann Surg 2012; 255: 1144.
19. Vianna R, Kubal C, Mangus R, Fridell J, Tector J,. Intestinal and multivisceral transplantation at Indiana University: 6 years' experience with 100 cases. In: Clinical Transplants. The Terasaki Foundation Laboratory, Los Angeles, CA, USA, 2009; 219-228.
20. Ekser B, Goggins W, Mangus R, et al,. Combined liver-kidney transplantation: simultaneous versus delayed transplantation of the kidney graft. Am J Transplant 2013; 13: 526.
21. Kubal CA, Mangus RS, Vianna RM, et al,. Impact of positive flow cytometry crossmatch on outcomes of intestinal/multivisceral transplantation: role anti-IL-2 receptor antibody. Transplantation 2013; 95: 1160.
22. Vianna RM, Mangus RS, Fridell JA, Weigman S, Kazimi M, Tector J,. Induction immunosuppression with thymoglobulin and rituximab in intestinal and multivisceral transplantation. Transplantation 2008; 85: 1290.
23. Remotti H, Subramanian S, Martinez M, Kato T, Magid MS,. Small-bowel allograft biopsies in the management of small-intestinal and multivisceral transplant recipients: histopathologic review and clinical correlations. Arch Pathol Lab Med 2012; 136: 761.
24. Englesbe MJ, Patel SP, He K, et al,. Sarcopenia and mortality after liver transplantation. J Am Coll Surg 2010; 211: 271.
25. Bogetti D, Sankary HN, Jarzembowski TM, et al,. Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury. Clin Transplant 2005; 19: 507.
26. Kim J, Ko ME, Nelson RA, et al,. Increasing age and survival after orthotopic liver transplantation for patients with hepatocellular cancer. J Am Coll Surg 2014; 218: 431.
27. Englesbe MJ, Terjimanian MN, Lee JS, et al,. Morphometric age and surgical risk. J Am Coll Surg 2013; 216: 976.