Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Madoz Gúrpide, Juan ^a   Zazo, Sandra ^a   Chamizo, Cristina ^a   Casado, Victoria ^b   Caramés, Cristina ^b   Gavín, Eduardo ^a   Cristóbal, Ion ^a   García Foncillas, Jesús ^b   Rojo, Federico ^a  

^a Instituto de Investigación Sanitaria Fundación Jiménez Díaz   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Cetuximab; EGFR; Head and neck squamous cell carcinoma (HNSCC); HGF; MET; Prognostic factor

Indexed keywords

CETUXIMAB; GROWTH FACTOR RECEPTOR; P MET PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; HGF PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; COHORT ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE AMPLIFICATION; GENE MUTATION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN TISSUE; LOG RANK TEST; MAJOR CLINICAL STUDY; MALE; MET GENE; METASTASIS; OVERALL SURVIVAL; PARACRINE SIGNALING; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; TREATMENT OUTCOME; DISEASE FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; HEAD AND NECK NEOPLASMS; METABOLISM; MIDDLE AGED; PAPILLOMAVIRIDAE; PATHOLOGY; PHOSPHORYLATION; PROGNOSIS; TUMOR RECURRENCE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; CETUXIMAB; DISEASE-FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION REGULATION; HEAD AND NECK NEOPLASMS; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PAPILLOMAVIRIDAE; PHOSPHORYLATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84940728821     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0633-7     Document Type: Article

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