ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells

Oncotarget

Volumn 6, Issue 25, 2015, Pages 21004-21015

  Liu, Xiaoye ^a,b   Yu, Xiaoting ^c   Xie, Jingjing ^d   Zhan, Mengna ^b   Yu, Zhuo ^b   Xie, Li ^b   Zeng, Hongxiang ^b   Zhang, Feifei ^b   Chen, Guoqiang ^a,b   Yi, Xianghua ^c   Zheng, Junke ^b  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d Bingzhou Medical University Taishan Scholar Program   (China)

Author keywords

ANGPTL2 LILRB2 signaling; CaMK1; Lung cancer; Metastasis

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOPROTEIN; IMMUNOGLOBULIN; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR SUBFAMILY B MEMBER 2; PROTEIN ANGPTL2; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG; ANGIOPOIETIN; ANGPTL2 PROTEIN, HUMAN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE I; CAMK1 PROTEIN, HUMAN; CREB1 PROTEIN, HUMAN; IMMUNOGLOBULIN RECEPTOR; LIGAND; LILRB2 PROTEIN, HUMAN; MEMBRANE PROTEIN; PTPN11 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER PATIENT; CANCER PROGNOSIS; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; NON SMALL CELL LUNG CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; LUNG TUMOR; METABOLISM; METASTASIS; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANGIOPOIETINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 1; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; LUNG NEOPLASMS; MEMBRANE GLYCOPROTEINS; NEOPLASM METASTASIS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84940728761     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4217     Document Type: Article

References (36)

1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA: a cancer journal for clinicians. 2014;64:9-29.
2. Herbst RS, Heymach JV, Lippman SM. Lung cancer. The New England journal of medicine. 2008;359:1367-1380.
3. Biesalski HK, Bueno de Mesquita B, Chesson A, Chytil F, Grimble R, Hermus RJ, Kohrle J, Lotan R, Norpoth K, Pastorino U, Thurnham D. European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel. CA: a cancer journal for clinicians. 1998;48:167-176; discussion 164-166.
4. Villeneuve PJ, Mao Y. Lifetime probability of developing lung cancer, by smoking status, Canada. Canadian journal of public health = Revue canadienne de sante publique. 1994;85:385-388.
5. Charkiewicz R, Niklinska W, Zalewski G, Charkiewicz A, Kozlowski M, Sulewska A, Chyczewski L. New monoallelic combination of KRAS gene mutations in codons 12 and 13 in the lung adenocarcinoma. Advances in medical sciences. 2013;58:83-89.
6. Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-194.
7. Hascher A, Haase AK, Hebestreit K, Rohde C, Klein HU, Rius M, Jungen D, Witten A, Stoll M, Schulze I, Ogawa S, Wiewrodt R, Tickenbrock L, et al. DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes. Clinical cancer research: an official journal of the American Association for Cancer Research. 2014;20:814-826.
8. Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, et al. Suppression of lung adenocarcinoma progression by Nkx2-1. Nature. 2011;473:101-104.
9. Yu H, Zhang H, Li D, Xue H, Pan C, Zhao S, Wang L. Effects of ANGPTL3 antisense oligodeoxynucleotides transfection on the cell growths and invasion of human hepatocellular carcinoma cells. Hepato-gastroenterology. 2011;58:1742-1746.
10. Rosell R, Robinet G, Szczesna A, Ramlau R, Constenla M, Mennecier BC, Pfeifer W, O'Byrne KJ, Welte T, Kolb R, Pirker R, Chemaissani A, Perol M, et al. Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO. 2008;19:362-369.
11. Wakelee H. Antibodies to vascular endothelial growth factor in non-small cell lung cancer. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. 2008;3:S113-118.
12. Hato T, Tabata M, Oike Y. The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends in cardiovascular medicine. 2008;18:6-14.
13. Li C. Not all angiopoietin-like proteins (Angptls) are created equal: insights from molecular, genetic, and pharmacological studies on the mechanism of LPL inhibition by Angptl3 and Angptl4. Current opinion in lipidology. 2009;20:357-359.
14. Camenisch G, Pisabarro MT, Sherman D, Kowalski J, Nagel M, Hass P, Xie MH, Gurney A, Bodary S, Liang XH, Clark K, Beresini M, Ferrara N, et al. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. The Journal of biological chemistry. 2002;277:17281-17290.
15. Ge H, Cha JY, Gopal H, Harp C, Yu X, Repa JJ, Li C. Differential regulation and properties of angiopoietin-like proteins 3 and 4. Journal of lipid research. 2005;46:1484-1490.
16. Koster A, Chao YB, Mosior M, Ford A, Gonzalez-DeWhitt PA, Hale JE, Li D, Qiu Y, Fraser CC, Yang DD, Heuer JG, Jaskunas SR, Eacho P. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005;146:4943-4950.
17. Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, Urano T, Zhu HJ, Tsukano H, Tazume H, Kaikita K, Miyashita K, Iwawaki T, et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell metabolism. 2009;10:178-188.
18. Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT, Jr., Raman V, Zhen L, Mitzner WA, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 2012;31:1757-1770.
19. Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, Huynh H, Kang X, Silvany R, Wan X, Ye J, Canto AP, Chen SH, et al. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature. 2012;485:656-660.
20. Kuo TC, Tan CT, Chang YW, Hong CC, Lee WJ, Chen MW, Jeng YM, Chiou J, Yu P, Chen PS, Wang MY, Hsiao M, Su JL, et al. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility. The Journal of clinical investigation. 2013;123:1082-1095.
21. Zhu P, Tan MJ, Huang RL, Tan CK, Chong HC, Pal M, Lam CR, Boukamp P, Pan JY, Tan SH, Kersten S, Li HY, Ding JL, et al. Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors. Cancer cell. 2011;19:401-415.
22. Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell. 2008;133:66-77.
23. Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T, Hirakawa S, et al. Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer research. 2011;71:7502-7512.
24. Endo M, Yamamoto Y, Nakano M, Masuda T, Odagiri H, Horiguchi H, Miyata K, Kadomatsu T, Motokawa I, Okada S, Iwase H, Oike Y. Serum ANGPTL2 levels reflect clinical features of breast cancer patients: implications for the pathogenesis of breast cancer metastasis. The International journal of biological markers. 2014;29:e239-245.
25. Zhang CC, Kaba M, Ge G, Xie K, Tong W, Hug C, Lodish HF. Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nature medicine. 2006;12:240-245.
26. Zhang CC, Kaba M, Iizuka S, Huynh H, Lodish HF. Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood. 2008;111:3415-3423.
27. Zheng J, Huynh H, Umikawa M, Silvany R, Zhang CC. Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. Blood. 2011;117:470-479.
28. Banchereau J, Zurawski S, Thompson-Snipes L, Blanck JP, Clayton S, Munk A, Cao Y, Wang Z, Khandelwal S, Hu J, McCoy WHt, Palucka KA, Reiter Y, et al. Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming. Proceedings of the National Academy of Sciences of the United States of America. 2012;109:18885-18890.
29. Baudhuin J, Migraine J, Faivre V, Loumagne L, Lukaszewicz AC, Payen D, Favier B. Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions. Proceedings of the National Academy of Sciences of the United States of America. 2013;110:17957-17962.
30. Zhang Y, Lu N, Xue Y, Zhang M, Li Y, Si Y, Bian X, Jia Y, Wang Y. Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance. Molecular medicine reports. 2012;5:910-916.
31. Sun Y, Liu J, Gao P, Wang Y, Liu C. Expression of Ig-like transcript 4 inhibitory receptor in human non-small cell lung cancer. Chest. 2008;134:783-788.
32. Xu Y, Liu YJ, Yu Q. Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis. Cancer research. 2004;64:6119-6126.
33. Baffari E, Fiume D, Caiazzo G, Sinistro A, Natoli S, Almerighi C, Calo-Carducci F, Leonardis F, Bergamini A. Upregulation of the inhibitory receptor ILT4 in monocytes from septic patients. Human immunology. 2013;74:1244-1250.
34. Ayatollahi H, Sharifi N, Sadeghian MH, Alenabi A, Ghasemian-Moghadam HR. Immunohistochemical expression of apoptosis regulators in squamous cell carcinoma of the cervix and their association with human papillomavirus 16/18 subtypes. Balkan medical journal. 2014;31:202-207.
35. Romeo S, Yin W, Kozlitina J, Pennacchio LA, Boerwinkle E, Hobbs HH, Cohen JC. Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. The Journal of clinical investigation. 2009;119:70-79.
36. Yi J, Pan BZ, Xiong L, Song HZ. Clinical significance of angiopoietin-like protein 4 expression in tissue and serum of esophageal squamous cell carcinoma patients. Med Oncol. 2013;30:680.