메뉴 건너뛰기




Volumn 36, Issue 9, 2015, Pages 507-518

Exploiting genomics and natural genetic variation to decode macrophage enhancers

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE; CHROMATIN IMMUNOPRECIPITATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DENDRITIC CELL; DNA METHYLATION; DNA SEQUENCE; ENHANCER REGION; ERYTHROCYTE; GENE EXPRESSION; GENETIC VARIABILITY; GENOMICS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; MACROPHAGE; MICROGLIA; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; POINT MUTATION; PROMOTER REGION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; ANTIBODY SPECIFICITY; CELL LINEAGE; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES;

EID: 84940592315     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2015.07.006     Document Type: Review
Times cited : (27)

References (127)
  • 1
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann F., et al. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656-661.
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1
  • 2
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn T.A., et al. Macrophage biology in development, homeostasis and disease. Nature 2013, 496:445-455.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1
  • 3
    • 77951631929 scopus 로고    scopus 로고
    • Differential roles of macrophages in diverse phases of skin repair
    • Lucas T., et al. Differential roles of macrophages in diverse phases of skin repair. J. Immunol. 2010, 184:3964-3977.
    • (2010) J. Immunol. , vol.184 , pp. 3964-3977
    • Lucas, T.1
  • 4
    • 84911092143 scopus 로고    scopus 로고
    • Macrophage heterogeneity in tissues: phenotypic diversity and functions
    • Gordon S., et al. Macrophage heterogeneity in tissues: phenotypic diversity and functions. Immunol. Rev. 2014, 262:36-55.
    • (2014) Immunol. Rev. , vol.262 , pp. 36-55
    • Gordon, S.1
  • 5
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli R.C., et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011, 333:1456-1458.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 6
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum S.L. Bone resorption by osteoclasts. Science 2000, 289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 7
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard J.I., et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447:1116-1120.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1
  • 8
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu Y., et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 2014, 157:1292-1308.
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1
  • 9
    • 0024992486 scopus 로고
    • Clearance and recycling of pulmonary surfactant
    • Wright J.R. Clearance and recycling of pulmonary surfactant. Am. J. Physiol. 1990, 259(2 Pt 1):L1-L12.
    • (1990) Am. J. Physiol. , vol.259 , Issue.2 , pp. L1-L12
    • Wright, J.R.1
  • 10
    • 79955535643 scopus 로고    scopus 로고
    • Macrophages in the pathogenesis of atherosclerosis
    • Moore K.J., Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
    • (2011) Cell , vol.145 , pp. 341-355
    • Moore, K.J.1    Tabas, I.2
  • 11
    • 0347123433 scopus 로고    scopus 로고
    • Tumour-educated macrophages promote tumour progression and metastasis
    • Pollard J.W. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 2004, 4:71-78.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 71-78
    • Pollard, J.W.1
  • 12
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: from mechanisms to therapy
    • Noy R., Pollard J.W. Tumor-associated macrophages: from mechanisms to therapy. Immunity 2014, 41:49-61.
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 13
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 14
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 15
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immuno 2008, 8.:958-969.
    • (2008) Nat. Rev. Immuno , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 16
    • 70349443224 scopus 로고    scopus 로고
    • Transcriptional control of the inflammatory response
    • Medzhitov R., Horng T. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 2009, 9:692-703.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 692-703
    • Medzhitov, R.1    Horng, T.2
  • 17
    • 84857052421 scopus 로고    scopus 로고
    • Transcriptional regulation in the innate immune system
    • Smale S.T. Transcriptional regulation in the innate immune system. Curr. Opin. Immunol. 2012, 24:51-57.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 51-57
    • Smale, S.T.1
  • 18
    • 0034046605 scopus 로고    scopus 로고
    • STAT family of transcription factors in cytokine-mediated biological responses
    • Takeda K., Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 2000, 11:199-207.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 199-207
    • Takeda, K.1    Akira, S.2
  • 19
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier E.L., et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 2012, 13:1118-1128.
    • (2012) Nat. Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1
  • 20
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • Gosselin D., et al. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 2014, 159:1327-1340.
    • (2014) Cell , vol.159 , pp. 1327-1340
    • Gosselin, D.1
  • 21
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin Y., et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 2014, 159:1312-1326.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1
  • 22
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-beta-dependent molecular and functional signature in microglia
    • Butovsky O., et al. Identification of a unique TGF-beta-dependent molecular and functional signature in microglia. Nat. Neurosci. 2014, 17:131-143.
    • (2014) Nat. Neurosci. , vol.17 , pp. 131-143
    • Butovsky, O.1
  • 23
    • 84900413094 scopus 로고    scopus 로고
    • Tissue-specific signals control reversible program of localization and functional polarization of macrophages
    • Okabe Y., Medzhitov R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell 2014, 157:832-844.
    • (2014) Cell , vol.157 , pp. 832-844
    • Okabe, Y.1    Medzhitov, R.2
  • 24
    • 34548454049 scopus 로고    scopus 로고
    • Biology of RANK, RANKL, and osteoprotegerin
    • Boyce B.F., Xing L. Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res. Ther. 2007, 9(Suppl. 1):S1.
    • (2007) Arthritis Res. Ther. , vol.9 , pp. S1
    • Boyce, B.F.1    Xing, L.2
  • 25
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • Heintzman N.D., et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 2007, 39:311-318.
    • (2007) Nat. Genet. , vol.39 , pp. 311-318
    • Heintzman, N.D.1
  • 26
    • 65549104157 scopus 로고    scopus 로고
    • Histone modifications at human enhancers reflect global cell-type-specific gene expression
    • Heintzman N.D., et al. Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature 2009, 459:108-112.
    • (2009) Nature , vol.459 , pp. 108-112
    • Heintzman, N.D.1
  • 27
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Consortium E.P., et al. An integrated encyclopedia of DNA elements in the human genome. Nature 2012, 489:57-74.
    • (2012) Nature , vol.489 , pp. 57-74
    • Consortium, E.P.1
  • 28
    • 84897459814 scopus 로고    scopus 로고
    • An atlas of active enhancers across human cell types and tissues
    • Andersson R., et al. An atlas of active enhancers across human cell types and tissues. Nature 2014, 507:455-461.
    • (2014) Nature , vol.507 , pp. 455-461
    • Andersson, R.1
  • 29
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Roadmap Epigenomics Consortium, et al. Integrative analysis of 111 reference human epigenomes. Nature 2015, 518:317-330.
    • (2015) Nature , vol.518 , pp. 317-330
  • 30
    • 84927559450 scopus 로고    scopus 로고
    • Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers
    • Core L.J., et al. Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers. Nat. Genet. 2014, 46:1311-1320.
    • (2014) Nat. Genet. , vol.46 , pp. 1311-1320
    • Core, L.J.1
  • 31
    • 0019811465 scopus 로고
    • Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences
    • Banerji J., et al. Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell 1981, 27:299-308.
    • (1981) Cell , vol.27 , pp. 299-308
    • Banerji, J.1
  • 32
    • 84923786414 scopus 로고    scopus 로고
    • The selection and function of cell type-specific enhancers
    • Heinz S., et al. The selection and function of cell type-specific enhancers. Nat. Rev. Mol. Cell Biol. 2015, 16:144-154.
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 144-154
    • Heinz, S.1
  • 33
    • 84899450857 scopus 로고    scopus 로고
    • Transcriptional enhancers: from properties to genome-wide predictions
    • Shlyueva D., et al. Transcriptional enhancers: from properties to genome-wide predictions. Nat. Rev. Genet. 2014, 15:272-286.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 272-286
    • Shlyueva, D.1
  • 34
    • 84865708757 scopus 로고    scopus 로고
    • An expansive human regulatory lexicon encoded in transcription factor footprints
    • Neph S., et al. An expansive human regulatory lexicon encoded in transcription factor footprints. Nature 2012, 489:83-90.
    • (2012) Nature , vol.489 , pp. 83-90
    • Neph, S.1
  • 35
    • 84888877924 scopus 로고    scopus 로고
    • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
    • Buenrostro J.D., et al. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat. Methods 2013, 10:1213-1218.
    • (2013) Nat. Methods , vol.10 , pp. 1213-1218
    • Buenrostro, J.D.1
  • 36
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A., et al. High-resolution profiling of histone methylations in the human genome. Cell 2007, 129:823-837.
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1
  • 37
    • 84655164920 scopus 로고    scopus 로고
    • Large-scale discovery of enhancers from human heart tissue
    • May D., et al. Large-scale discovery of enhancers from human heart tissue. Nat. Genet. 2012, 44:89-93.
    • (2012) Nat. Genet. , vol.44 , pp. 89-93
    • May, D.1
  • 38
    • 84899692444 scopus 로고    scopus 로고
    • Function-based identification of mammalian enhancers using site-specific integration
    • Dickel D.E., et al. Function-based identification of mammalian enhancers using site-specific integration. Nat. Methods 2014, 11:566-571.
    • (2014) Nat. Methods , vol.11 , pp. 566-571
    • Dickel, D.E.1
  • 39
    • 84883457107 scopus 로고    scopus 로고
    • Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model
    • Smith R.P., et al. Massively parallel decoding of mammalian regulatory sequences supports a flexible organizational model. Nat. Genet. 2013, 45:1021-1028.
    • (2013) Nat. Genet. , vol.45 , pp. 1021-1028
    • Smith, R.P.1
  • 40
    • 84874381107 scopus 로고    scopus 로고
    • Genome-wide quantitative enhancer activity maps identified by STARR-seq
    • Arnold C.D., et al. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science 2013, 339:1074-1077.
    • (2013) Science , vol.339 , pp. 1074-1077
    • Arnold, C.D.1
  • 41
    • 84928136624 scopus 로고    scopus 로고
    • High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq
    • Vanhille L., et al. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Nat. Commun. 2015, 6:6905.
    • (2015) Nat. Commun. , vol.6 , pp. 6905
    • Vanhille, L.1
  • 42
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • Ernst J., et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011, 473:43-49.
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1
  • 43
    • 77950262538 scopus 로고    scopus 로고
    • Nucleosome dynamics define transcriptional enhancers
    • He H.H., et al. Nucleosome dynamics define transcriptional enhancers. Nat. Genet. 2010, 42:343-347.
    • (2010) Nat. Genet. , vol.42 , pp. 343-347
    • He, H.H.1
  • 44
    • 79951516056 scopus 로고    scopus 로고
    • A unique chromatin signature uncovers early developmental enhancers in humans
    • Rada-Iglesias A., et al. A unique chromatin signature uncovers early developmental enhancers in humans. Nature 2011, 470:279-283.
    • (2011) Nature , vol.470 , pp. 279-283
    • Rada-Iglesias, A.1
  • 45
    • 78650758676 scopus 로고    scopus 로고
    • Histone H3K27ac separates active from poised enhancers and predicts developmental state
    • Creyghton M.P., et al. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:21931-21936.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 21931-21936
    • Creyghton, M.P.1
  • 46
    • 77952908743 scopus 로고    scopus 로고
    • A large fraction of extragenic RNA pol II transcription sites overlap enhancers
    • De Santa F., et al. A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol. 2010, 8:e1000384.
    • (2010) PLoS Biol. , vol.8 , pp. e1000384
    • De Santa, F.1
  • 47
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • Kim T.K., et al. Widespread transcription at neuronal activity-regulated enhancers. Nature 2010, 465:182-187.
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.K.1
  • 48
    • 84879694221 scopus 로고    scopus 로고
    • Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
    • Lam M.T., et al. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature 2013, 498:511-515.
    • (2013) Nature , vol.498 , pp. 511-515
    • Lam, M.T.1
  • 49
    • 84922391291 scopus 로고    scopus 로고
    • Enhancer RNA facilitates NELF release from immediate early genes
    • Schaukowitch K., et al. Enhancer RNA facilitates NELF release from immediate early genes. Mol. Cell 2014, 56:29-42.
    • (2014) Mol. Cell , vol.56 , pp. 29-42
    • Schaukowitch, K.1
  • 50
    • 84901020399 scopus 로고    scopus 로고
    • Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation
    • Hsieh C.L., et al. Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:7319-7324.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 7319-7324
    • Hsieh, C.L.1
  • 51
    • 84879695128 scopus 로고    scopus 로고
    • Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
    • Li W., et al. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature 2013, 498:516-520.
    • (2013) Nature , vol.498 , pp. 516-520
    • Li, W.1
  • 52
    • 84881526410 scopus 로고    scopus 로고
    • Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
    • Kaikkonen M.U., et al. Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription. Mol. Cell 2013, 51:310-325.
    • (2013) Mol. Cell , vol.51 , pp. 310-325
    • Kaikkonen, M.U.1
  • 53
    • 84856239091 scopus 로고    scopus 로고
    • Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
    • Bonn S., et al. Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development. Nat. Genet. 2012, 44:148-156.
    • (2012) Nat. Genet. , vol.44 , pp. 148-156
    • Bonn, S.1
  • 54
    • 84894589713 scopus 로고    scopus 로고
    • Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation
    • Kieffer-Kwon K.R., et al. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell 2013, 155:1507-1520.
    • (2013) Cell , vol.155 , pp. 1507-1520
    • Kieffer-Kwon, K.R.1
  • 55
    • 79959198166 scopus 로고    scopus 로고
    • Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA
    • Wang D., et al. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 2011, 474:390-394.
    • (2011) Nature , vol.474 , pp. 390-394
    • Wang, D.1
  • 56
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: establishing competence for gene expression
    • Zaret K.S., Carroll J.S. Pioneer transcription factors: establishing competence for gene expression. Genes Dev. 2011, 25:2227-2241.
    • (2011) Genes Dev. , vol.25 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 57
    • 0034916613 scopus 로고    scopus 로고
    • P300/CBP proteins: HATs for transcriptional bridges and scaffolds
    • Chan H.M., La Thangue N.B. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 2001, 114:2363-2373.
    • (2001) J. Cell Sci. , vol.114 , pp. 2363-2373
    • Chan, H.M.1    La Thangue, N.B.2
  • 58
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S., et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 2010, 38:576-589.
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 59
    • 0028136726 scopus 로고
    • Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
    • Scott E.W., et al. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994, 265:1573-1577.
    • (1994) Science , vol.265 , pp. 1573-1577
    • Scott, E.W.1
  • 60
    • 0242549003 scopus 로고    scopus 로고
    • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    • McKercher S.R., et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996, 15:5647-5658.
    • (1996) EMBO J. , vol.15 , pp. 5647-5658
    • McKercher, S.R.1
  • 61
    • 84907419194 scopus 로고    scopus 로고
    • Immunogenetics. Chromatin state dynamics during blood formation
    • Lara-Astiaso D., et al. Immunogenetics. Chromatin state dynamics during blood formation. Science 2014, 345:943-949.
    • (2014) Science , vol.345 , pp. 943-949
    • Lara-Astiaso, D.1
  • 62
    • 84884959191 scopus 로고    scopus 로고
    • Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development
    • Kazemian M., et al. Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development. Nucleic Acids Res. 2013, 41:8237-8252.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 8237-8252
    • Kazemian, M.1
  • 63
    • 84911494217 scopus 로고    scopus 로고
    • Principles of regulatory information conservation between mouse and human
    • Cheng Y., et al. Principles of regulatory information conservation between mouse and human. Nature 2014, 515:371-375.
    • (2014) Nature , vol.515 , pp. 371-375
    • Cheng, Y.1
  • 64
    • 84911470871 scopus 로고    scopus 로고
    • Conservation of trans-acting circuitry during mammalian regulatory evolution
    • Stergachis A.B., et al. Conservation of trans-acting circuitry during mammalian regulatory evolution. Nature 2014, 515:365-370.
    • (2014) Nature , vol.515 , pp. 365-370
    • Stergachis, A.B.1
  • 65
    • 79251543942 scopus 로고    scopus 로고
    • Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development
    • McConnell S.C., et al. Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. Mol. Cell Biol. 2011, 31:876-883.
    • (2011) Mol. Cell Biol. , vol.31 , pp. 876-883
    • McConnell, S.C.1
  • 66
    • 0027261194 scopus 로고
    • Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes
    • Peterson K.R., et al. Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:7593-7597.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7593-7597
    • Peterson, K.R.1
  • 67
    • 84916880365 scopus 로고    scopus 로고
    • Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
    • Dowen J.M., et al. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell 2014, 159:374-387.
    • (2014) Cell , vol.159 , pp. 374-387
    • Dowen, J.M.1
  • 68
    • 84888015137 scopus 로고    scopus 로고
    • Super-enhancers in the control of cell identity and disease
    • Hnisz D., et al. Super-enhancers in the control of cell identity and disease. Cell 2013, 155:934-947.
    • (2013) Cell , vol.155 , pp. 934-947
    • Hnisz, D.1
  • 69
    • 84876216563 scopus 로고    scopus 로고
    • Master transcription factors and mediator establish super-enhancers at key cell identity genes
    • Whyte W.A., et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 2013, 153:307-319.
    • (2013) Cell , vol.153 , pp. 307-319
    • Whyte, W.A.1
  • 70
    • 84887072795 scopus 로고    scopus 로고
    • Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
    • Parker S.C., et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:17921-17926.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 17921-17926
    • Parker, S.C.1
  • 71
    • 84925283769 scopus 로고    scopus 로고
    • What are super-enhancers?
    • Pott S., Lieb J.D. What are super-enhancers?. Nat. Genet. 2015, 47:8-12.
    • (2015) Nat. Genet. , vol.47 , pp. 8-12
    • Pott, S.1    Lieb, J.D.2
  • 72
    • 0023550898 scopus 로고
    • Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
    • Forrester W.C., et al. Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Res. 1987, 15:10159-10177.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 10159-10177
    • Forrester, W.C.1
  • 73
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human beta-globin gene in transgenic mice
    • Grosveld F., et al. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 1987, 51:975-985.
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1
  • 74
    • 0344272073 scopus 로고
    • The 'beta-like-globin' gene domain in human erythroid cells
    • Tuan D., et al. The 'beta-like-globin' gene domain in human erythroid cells. Proc. Natl. Acad. Sci. U.S.A. 1985, 82:6384-6388.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 6384-6388
    • Tuan, D.1
  • 75
    • 84890129231 scopus 로고    scopus 로고
    • Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors
    • May G., et al. Dynamic analysis of gene expression and genome-wide transcription factor binding during lineage specification of multipotent progenitors. Cell Stem Cell 2013, 13:754-768.
    • (2013) Cell Stem Cell , vol.13 , pp. 754-768
    • May, G.1
  • 76
    • 84856738988 scopus 로고    scopus 로고
    • Hematopoiesis: a human perspective
    • Doulatov S., et al. Hematopoiesis: a human perspective. Cell Stem Cell 2012, 10:120-136.
    • (2012) Cell Stem Cell , vol.10 , pp. 120-136
    • Doulatov, S.1
  • 77
    • 84878292277 scopus 로고    scopus 로고
    • Transcriptional and epigenetic dynamics during specification of human embryonic stem cells
    • Gifford C.A., et al. Transcriptional and epigenetic dynamics during specification of human embryonic stem cells. Cell 2013, 153:1149-1163.
    • (2013) Cell , vol.153 , pp. 1149-1163
    • Gifford, C.A.1
  • 78
    • 78650996389 scopus 로고    scopus 로고
    • Reprogramming factor expression initiates widespread targeted chromatin remodeling
    • Koche R.P., et al. Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell 2011, 8:96-105.
    • (2011) Cell Stem Cell , vol.8 , pp. 96-105
    • Koche, R.P.1
  • 79
    • 84923366467 scopus 로고    scopus 로고
    • Transcription factor binding dynamics during human ES cell differentiation
    • Tsankov A.M., et al. Transcription factor binding dynamics during human ES cell differentiation. Nature 2015, 518:344-349.
    • (2015) Nature , vol.518 , pp. 344-349
    • Tsankov, A.M.1
  • 80
    • 72849110608 scopus 로고    scopus 로고
    • Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells
    • Xu J., et al. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev. 2009, 23:2824-2838.
    • (2009) Genes Dev. , vol.23 , pp. 2824-2838
    • Xu, J.1
  • 81
    • 84859157183 scopus 로고    scopus 로고
    • Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity
    • Zhang J.A., et al. Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity. Cell 2012, 149:467-482.
    • (2012) Cell , vol.149 , pp. 467-482
    • Zhang, J.A.1
  • 82
    • 84923382398 scopus 로고    scopus 로고
    • Dissecting neural differentiation regulatory networks through epigenetic footprinting
    • Ziller M.J., et al. Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature 2015, 518:355-359.
    • (2015) Nature , vol.518 , pp. 355-359
    • Ziller, M.J.1
  • 83
    • 3543038232 scopus 로고    scopus 로고
    • Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2
    • Anguita E., et al. Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J. 2004, 23:2841-2852.
    • (2004) EMBO J. , vol.23 , pp. 2841-2852
    • Anguita, E.1
  • 84
    • 0041806587 scopus 로고    scopus 로고
    • GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling
    • Grass J.A., et al. GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:8811-8816.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 8811-8816
    • Grass, J.A.1
  • 85
    • 84890808924 scopus 로고    scopus 로고
    • Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
    • Gao X., et al. Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J. Exp. Med. 2013, 210:2833-2842.
    • (2013) J. Exp. Med. , vol.210 , pp. 2833-2842
    • Gao, X.1
  • 86
    • 84859224243 scopus 로고    scopus 로고
    • Widespread site-dependent buffering of human regulatory polymorphism
    • Maurano M.T., et al. Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet. 2012, 8:e1002599.
    • (2012) PLoS Genet. , vol.8 , pp. e1002599
    • Maurano, M.T.1
  • 87
    • 84923046255 scopus 로고    scopus 로고
    • Cholesterol, inflammation and innate immunity
    • Tall A.R., Yvan-Charvet L. Cholesterol, inflammation and innate immunity. Nat. Rev. Immunol. 2015, 15:104-116.
    • (2015) Nat. Rev. Immunol. , vol.15 , pp. 104-116
    • Tall, A.R.1    Yvan-Charvet, L.2
  • 88
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1:135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 89
    • 84888641656 scopus 로고    scopus 로고
    • Effect of natural genetic variation on enhancer selection and function
    • Heinz S., et al. Effect of natural genetic variation on enhancer selection and function. Nature 2013, 503:487-492.
    • (2013) Nature , vol.503 , pp. 487-492
    • Heinz, S.1
  • 90
    • 84872522528 scopus 로고    scopus 로고
    • Latent enhancers activated by stimulation in differentiated cells
    • Ostuni R., et al. Latent enhancers activated by stimulation in differentiated cells. Cell 2013, 152:157-171.
    • (2013) Cell , vol.152 , pp. 157-171
    • Ostuni, R.1
  • 91
    • 77949977555 scopus 로고    scopus 로고
    • Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages
    • Ghisletti S., et al. Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity 2010, 32:317-328.
    • (2010) Immunity , vol.32 , pp. 317-328
    • Ghisletti, S.1
  • 92
    • 84866303839 scopus 로고    scopus 로고
    • A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals
    • Garber M., et al. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol. Cell 2012, 47:810-822.
    • (2012) Mol. Cell , vol.47 , pp. 810-822
    • Garber, M.1
  • 93
    • 0036184236 scopus 로고    scopus 로고
    • Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4
    • Cirillo L.A., et al. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol. Cell 2002, 9:279-289.
    • (2002) Mol. Cell , vol.9 , pp. 279-289
    • Cirillo, L.A.1
  • 94
    • 80155137594 scopus 로고    scopus 로고
    • Master transcription factors determine cell-type-specific responses to TGF-beta signaling
    • Mullen A.C., et al. Master transcription factors determine cell-type-specific responses to TGF-beta signaling. Cell 2011, 147:565-576.
    • (2011) Cell , vol.147 , pp. 565-576
    • Mullen, A.C.1
  • 95
    • 84866975037 scopus 로고    scopus 로고
    • Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    • Samstein R.M., et al. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell 2012, 151:153-166.
    • (2012) Cell , vol.151 , pp. 153-166
    • Samstein, R.M.1
  • 96
    • 79952184341 scopus 로고    scopus 로고
    • Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
    • John S., et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat. Genet. 2011, 43:264-268.
    • (2011) Nat. Genet. , vol.43 , pp. 264-268
    • John, S.1
  • 97
    • 78650210727 scopus 로고    scopus 로고
    • Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response
    • Barish G.D., et al. Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev. 2010, 24:2760-2765.
    • (2010) Genes Dev. , vol.24 , pp. 2760-2765
    • Barish, G.D.1
  • 98
    • 84870027825 scopus 로고    scopus 로고
    • STATs shape the active enhancer landscape of T cell populations
    • Vahedi G., et al. STATs shape the active enhancer landscape of T cell populations. Cell 2012, 151:981-993.
    • (2012) Cell , vol.151 , pp. 981-993
    • Vahedi, G.1
  • 99
    • 80155123782 scopus 로고    scopus 로고
    • Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
    • Trompouki E., et al. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell 2011, 147:577-589.
    • (2011) Cell , vol.147 , pp. 577-589
    • Trompouki, E.1
  • 100
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow M.E., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 2001, 27:68-73.
    • (2001) Nat. Genet. , vol.27 , pp. 68-73
    • Brunkow, M.E.1
  • 101
    • 0037385314 scopus 로고    scopus 로고
    • + T regulatory cells
    • + T regulatory cells. Nat. Immunol. 2003, 4:337-342.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1
  • 102
    • 33748588423 scopus 로고    scopus 로고
    • + T helper cells
    • + T helper cells. Cell 2006, 126:1121-1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1
  • 103
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo S.J., et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000, 100:655-669.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1
  • 104
    • 84867581744 scopus 로고    scopus 로고
    • A validated regulatory network for Th17 cell specification
    • Ciofani M., et al. A validated regulatory network for Th17 cell specification. Cell 2012, 151:289-303.
    • (2012) Cell , vol.151 , pp. 289-303
    • Ciofani, M.1
  • 105
    • 84867861268 scopus 로고    scopus 로고
    • BATF-JUN is critical for IRF4-mediated transcription in T cells
    • Li P., et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 2012, 490:543-546.
    • (2012) Nature , vol.490 , pp. 543-546
    • Li, P.1
  • 106
    • 77950833803 scopus 로고    scopus 로고
    • Variation in transcription factor binding among humans
    • Kasowski M., et al. Variation in transcription factor binding among humans. Science 2010, 328:232-235.
    • (2010) Science , vol.328 , pp. 232-235
    • Kasowski, M.1
  • 107
    • 84887322043 scopus 로고    scopus 로고
    • Identification of genetic variants that affect histone modifications in human cells
    • McVicker G., et al. Identification of genetic variants that affect histone modifications in human cells. Science 2013, 342:747-749.
    • (2013) Science , vol.342 , pp. 747-749
    • McVicker, G.1
  • 108
    • 84904407541 scopus 로고    scopus 로고
    • Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
    • Gautier E.L., et al. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J. Exp. Med. 2014, 211:1525-1531.
    • (2014) J. Exp. Med. , vol.211 , pp. 1525-1531
    • Gautier, E.L.1
  • 109
    • 35448977192 scopus 로고    scopus 로고
    • Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS
    • Makwana M., et al. Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. J. Neurosci. 2007, 27:11201-11213.
    • (2007) J. Neurosci. , vol.27 , pp. 11201-11213
    • Makwana, M.1
  • 110
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff L.A., et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:9362-9367.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1
  • 111
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano M.T., et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 2012, 337:1190-1195.
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1
  • 112
    • 84923326765 scopus 로고    scopus 로고
    • Genetic and epigenetic fine mapping of causal autoimmune disease variants
    • Farh K.K., et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2015, 518:337-343.
    • (2015) Nature , vol.518 , pp. 337-343
    • Farh, K.K.1
  • 113
    • 84873086126 scopus 로고    scopus 로고
    • Chromatin marks identify critical cell types for fine mapping complex trait variants
    • Trynka G., et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat. Genet. 2013, 45:124-130.
    • (2013) Nat. Genet. , vol.45 , pp. 124-130
    • Trynka, G.1
  • 114
    • 84887320760 scopus 로고    scopus 로고
    • Extensive variation in chromatin states across humans
    • Kasowski M., et al. Extensive variation in chromatin states across humans. Science 2013, 342:750-752.
    • (2013) Science , vol.342 , pp. 750-752
    • Kasowski, M.1
  • 115
    • 84887320563 scopus 로고    scopus 로고
    • Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription
    • Kilpinen H., et al. Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription. Science 2013, 342:744-747.
    • (2013) Science , vol.342 , pp. 744-747
    • Kilpinen, H.1
  • 116
    • 84896759364 scopus 로고    scopus 로고
    • Common genetic variants modulate pathogen-sensing responses in human dendritic cells
    • Lee M.N., et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 2014, 343:1246980.
    • (2014) Science , vol.343 , pp. 1246980
    • Lee, M.N.1
  • 117
    • 84900338300 scopus 로고    scopus 로고
    • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    • Raj T., et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 2014, 344:519-523.
    • (2014) Science , vol.344 , pp. 519-523
    • Raj, T.1
  • 118
    • 84907202723 scopus 로고    scopus 로고
    • Intersection of population variation and autoimmunity genetics in human T cell activation
    • Ye C.J., et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science 2014, 345:1254665.
    • (2014) Science , vol.345 , pp. 1254665
    • Ye, C.J.1
  • 119
    • 60349092402 scopus 로고    scopus 로고
    • Mapping complex disease traits with global gene expression
    • Cookson W., et al. Mapping complex disease traits with global gene expression. Nat. Rev. Genet. 2009, 10:184-194.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 184-194
    • Cookson, W.1
  • 120
    • 84896742056 scopus 로고    scopus 로고
    • Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
    • Fairfax B.P., et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 2014, 343:1246949.
    • (2014) Science , vol.343 , pp. 1246949
    • Fairfax, B.P.1
  • 121
    • 77649236340 scopus 로고    scopus 로고
    • Systems genetics analysis of gene-by-environment interactions in human cells
    • Romanoski C.E., et al. Systems genetics analysis of gene-by-environment interactions in human cells. Am. J. Hum. Genet. 2010, 86:399-410.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 399-410
    • Romanoski, C.E.1
  • 122
    • 84868036620 scopus 로고    scopus 로고
    • Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
    • Orozco L.D., et al. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 2012, 151:658-670.
    • (2012) Cell , vol.151 , pp. 658-670
    • Orozco, L.D.1
  • 123
    • 79951473520 scopus 로고    scopus 로고
    • 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response
    • Harismendy O., et al. 9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response. Nature 2011, 470:264-268.
    • (2011) Nature , vol.470 , pp. 264-268
    • Harismendy, O.1
  • 124
    • 84879604583 scopus 로고    scopus 로고
    • Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization
    • Hawkins R.D., et al. Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity 2013, 38:1271-1284.
    • (2013) Immunity , vol.38 , pp. 1271-1284
    • Hawkins, R.D.1
  • 125
    • 70349873824 scopus 로고    scopus 로고
    • Comprehensive mapping of long-range interactions reveals folding principles of the human genome
    • Lieberman-Aiden E., et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 2009, 326:289-293.
    • (2009) Science , vol.326 , pp. 289-293
    • Lieberman-Aiden, E.1
  • 126
    • 84865800494 scopus 로고    scopus 로고
    • The long-range interaction landscape of gene promoters
    • Sanyal A., et al. The long-range interaction landscape of gene promoters. Nature 2012, 489:109-113.
    • (2012) Nature , vol.489 , pp. 109-113
    • Sanyal, A.1
  • 127
    • 84918551761 scopus 로고    scopus 로고
    • A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential
    • Zhou H.Y., et al. A Sox2 distal enhancer cluster regulates embryonic stem cell differentiation potential. Genes Dev. 2014, 28:2699-2711.
    • (2014) Genes Dev. , vol.28 , pp. 2699-2711
    • Zhou, H.Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.