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Olaparib Monotherapy in Patients with Advanced Cancer and a Germline BRCA1/2 Mutation
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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
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Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
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Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
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BRACAnalysis Post Market Approval. Available from: www.accessdata.fda.gov/cdrh-docs/pdf14/P140020a.pdf
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Olaparib maintenance monotherapy in patients with BRCA mutated ovarian cancer following first line platinum based chemotherapy. (SOLO-1). Available from: https://clinicaltrials.gov/ct2/show/NCT01844986
Olaparib treatment in BRCA mutated ovarian cancer patients after complete or partial response to platinum chemotherapy. Available from: https://clinicaltrials.gov/ct2/show/NCT01874353