Toxicity of zinc oxide nanoparticles on adult male Wistar rats

Food and Chemical Toxicology

Volumn 84, Issue , 2015, Pages 154-160

  Abbasalipourkabir, Roghayeh ^a   Moradi, Hemen ^b   Zarei, Sadegh ^c   Asadi, Soheila ^a   Salehzadeh, Aref ^a   Ghafourikhosroshahi, Abolfazl ^d   Mortazavi, Motahareh ^a   Ziamajidi, Nasrin ^a  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c YAZD UNIVERSITY   (Iran)

^d HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Histopathology; Liver enzyme; Oxidative stress system; Sperm analysis; ZnO nanoparticles

Indexed keywords

GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; ZINC OXIDE NANOPARTICLE; BIOLOGICAL MARKER; METAL NANOPARTICLE; OXIDOREDUCTASE; ZINC OXIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY PARENCHYMA; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; RAT; SEMEN ANALYSIS; TOXICITY; WISTAR RAT; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIPID PEROXIDATION; METABOLISM; NEPHRITIS; OLIGOSPERMIA; PATHOLOGY; PATHOPHYSIOLOGY; TISSUE DISTRIBUTION; TOXIC HEPATITIS; TOXICITY TESTING; TOXICOKINETICS; ULTRASTRUCTURE;

ANIMALS; BIOMARKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; INJECTIONS, INTRAPERITONEAL; KIDNEY; LIPID PEROXIDATION; LIVER; MALE; METAL NANOPARTICLES; NEPHRITIS; OLIGOSPERMIA; OXIDATIVE STRESS; OXIDOREDUCTASES; RATS, WISTAR; SEMEN ANALYSIS; TISSUE DISTRIBUTION; TOXICITY TESTS, SUBACUTE; TOXICOKINETICS; ZINC OXIDE;

EID: 84940517601     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.08.019     Document Type: Article

References (35)

1. Ahamed M., Akhtar M.,J., Raja M., Ahmad I., Siddiqui M.K.J., AlSalhi M.S., Alrokayan S.A. ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine 2011, 7(6):904-913.
2. Al-Suhaibani E.S., El-Morshedi N.A. Histopathological and ultrastructural effect of zinc oxide nanoparticles on male wistar rats submandibular glands. IOSR J. Pharm. Biol. Sci. (IOSR-JPBS) 2014, 9(6):5-9.
3. Al-Taee S.K.I., AL-Hamdani A.H.A. Pathological study of lethal concentration of n-zno in common carp cyprinus carpiol. Basrah J. Vet. Res. 2013, 12(1).
4. Benzie I.F.F., Strain J.J. The Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Method Enzym. 1999, 299:15-27.
5. Botsoglou N.A., Fletouris D.J., Papageorgiou G.E., Vassilopoulos V.N., Mantis A.J., Trakatellis A.G. Rapid, sensitive, and specific thiobarbituric acid method for measuring lipid peroxidation in animal tissue, food, and feedstuff samples. J. Agric. Food Chem. 1994, 42:1931-1937.
6. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 2005, 38(12):1103-1111.
7. Esmaeillou M., Moharamnejad M., Hsankhani R., Tehrani A.S., Maadi H. Toxicity of ZnO nanoparticles in healthy adult mice. Environ. Toxicol. Pharmacol. 2013, 35:67-71.
8. Fischer H.C., Chan W.C. Nanotoxicity: the growing need for in vivo study. Curr. Opin. Biotechnol. 2007, 18:565-571.
9. Gerloff K., Albrecht C., Boots A.W., Förster I., Schins R.P.F. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 2009, 3:355-364.
10. Gojova A., Guo B., Kota R.S., Rutledge J.C., Kennedy I.M., Barakat A.I. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ. Health Perspect. 2007, 115:403-409.
11. Hackenberg S., Scherzed A., Technau A., Kessler M., Froelich K., Ginzkey C., Koehler C., Burghartz M., Hagen R., Kleinsasser N. Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro. Toxicol. In Vitro 2011, 25(3):657-663.
12. Heng B.C., Zhao X., Xiong S., Ng K.W., Boey F.Y.-C., Loo J.,S.-C. Toxicity of zinc oxide (ZnO) nanoparticles on human bronchial epithelial cells (BEAS-2B) is accentuated by oxidative stress. Food Chem. Toxicol. 2010, 48:1762-1766.
13. Hussain N., Jaitley V., Florence A.T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 2001, 50:107-142.
14. Jeng H.A., Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J. Environ. Sci. Health. Part A Environ. Sci. Eng. Toxic Hazard. Subst. Control 2006, 41:2699-2711.
15. Jin T., Sun D., Su J.Y., Zhang H., Sue H.J. Antimicrobial efficacy of zinc oxide quantum dots against Listeria monocytogenes, Salmonella enteritidis, and Escherichia coli O157:H7. J. Food Sci. 2009, 74:M46-M52.
16. John S., Marpu S., Li J., Omary M., Hu Z., Fujita Y., Neogi A. Hybrid zinc oxide nanoparticles for biophotonics. J. Nanosci. Nanotechnol. 2010, 10:1707-1712.
17. Klaine S.J., Alvarez P.J.J., Batley G.E., Fernandes T.F., Handy R.D., Lyon D.Y., Mahendra S., MClaughlin M.J., Lead J.R. Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environ. Toxicol. Chem. 2008, 27(9):1825-1851.
18. Lynch E.D., Gu R., Pierce C., Kil J. Combined oral delivery of ebselen and allopurinol reduces multiple cisplatin toxicities in rat breast and ovarian cancer models while enhancing anti-tumor activity. Anticancer Drugs 2005, 16:569-579.
19. Manzo S., Miglietta M.L., Rametta G., Buono S., Di Francia G. Embriotoxicity and spermiotoxicity of nanosized ZnO for Mediterranean seaurchin Paracentrotus lividus. J. Hazard. Mater. 2013, 254-255:1-9. 15.
20. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
21. Najafzadeh H., Ghoreish S.M., Mohammadian B., Rahimi E., Afzalzadeh M.R., Kazemivarnamkhasti M., Ganjealidaran H. Serum biochemical and histopathological changes in liver and kidney in lambs after zinc oxide nanoparticles administration. Vet. World 2013, 6(8):534-537.
22. Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005, 113:823-839.
23. Osman I.F., Baumgartner A., Cemeli E., Fletcher J.N., Anderson D. Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine (Lond) 2010, 5:1193-1203.
24. Paglia D.E., Valentine W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70:158-169.
25. Rasmussen J.W., Martinez E., Louka P., Wingett D.G. Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications. Expert Opin. Drug Deliv. 2010, 7:1063-1077.
26. Saman S., Moradhaseli S., Shokouhian A., Ghorbani M. Histopathological effects of ZnO nanoparticles on liver and heart tissues in wistar rats. Adv. Bioresearch 2013, 2:83-88.
27. Sharma V., Singh P., Pandey A.K., Dhawan A. Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat. Res. 2012, 45:84-91.
28. Sharma V., Singh S.K., Anderson D., Tobin D.J., Dhawan A. Zinc oxide nanoparticle induced genotoxicity in primary human epidermal keratinocytes. J. Nanosci. Nanotechnol. 2011, 11:3782-3788.
29. Sharma V., Shukla R.K., Saxena N., Parmara D., Das Mukul, Dhawan Alok DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol. Lett. 2009, 185:211-218.
30. Talebi A.R., Khorsandi L., Moridian M. The effect of zinc oxide nanoparticles on mouse spermatogenesis. J. Assist. Reprod. Genet. 2013, 30:1203-1209.
31. Wahaba R., Kima Y.-S., Hwangb I.H., Shin H.-S. A non-aqueous synthesis, characterization of zinc oxide nanoparticles and their interaction with DNA. Synth. Met. 2009, 159:2443-2452.
32. Wang B., Feng W.-Y., Wang T.-C., Jia G., Wang M., Shi J.-W., Zhang F., Zhao Y.-L., Chai Z.-F. Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice. Toxicol. Lett. 2006, 161:115-123.
33. Wang H.J., Growcock A.C., Tang T.H., O'Hara J., Huang Y.W., Aronstam R.S. Zinc oxide nanoparticle disruption of store-operated calcium entry in a muscarinic receptor signaling pathway. Toxicol. In Vitro 2010, 24:1953-1961.
34. Wang B., Feng W., Wang M., Wang T., Gu Y., Zhu M., Ouyang H., Shi J., Zhang F., Zhao Y., Chai Z., Wang H., Wang J. Acute toxicological impact of nano- and submicro-scaled. J. Nanoparticle Res. 2008, 10:263-276.
35. Yang H., Liu C., Yang D., Zhang H., Xi Z. Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J. Appl. Toxicol. 2009, 29:69-78.