Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans

Brain

Volumn 138, Issue 6, 2015, Pages 1658-1666

  Herz, Damian M ^a,b   Haagensen, Brian N ^a   Christensen, Mark S ^a,c   Madsen, Kristoffer H ^a,d   Rowe, James B ^e,f,g   Løkkegaard, Annemette ^b   Siebner, Hartwig R ^a,b,h  

^a HVIDOVRE HOSPITAL   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f MRC COGNITION AND BRAIN SCIENCES UNIT   (United Kingdom)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Connectivity; Dynamic causal modelling; Functional MRI; Levodopa induced dyskinesia; Parkinson's disease

Indexed keywords

BENSERAZIDE; LEVODOPA; ANTIPARKINSON AGENT;

ADULT; AGED; ARTICLE; ASSOCIATION; BRAIN GANGLION; CLINICAL ARTICLE; CONNECTOME; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG MEGADOSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LEVODOPA-INDUCED DYSKINESIA; MALE; NEUROIMAGING; NEUROMODULATION; NUCLEAR MAGNETIC RESONANCE SCANNER; PARKINSON DISEASE; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PUTAMEN; SINGLE DRUG DOSE; VERY ELDERLY; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; DYSKINESIA; FUNCTIONAL NEUROIMAGING; MIDDLE AGED; MOTOR CORTEX; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE;

AGED; AGED, 80 AND OVER; ANTIPARKINSON AGENTS; DOPAMINERGIC NEURONS; DYSKINESIA, DRUG-INDUCED; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; LEVODOPA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTOR CORTEX; NEURAL PATHWAYS; PSYCHOMOTOR PERFORMANCE; PUTAMEN;

EID: 84940454402     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv096     Document Type: Article

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