Antithrombin Concentrate Use in Children Receiving Unfractionated Heparin for Acute Thrombosis

Journal of Pediatrics

Volumn 167, Issue 3, 2015, Pages 645-649

  Diaz, Rosa ^a   Moffett, Brady S ^a   Karabinas, Shaina ^a   Guffrey, Danielle ^b   Mahoney, Donald H ^a   Yee, Donald L ^a  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; ANTITHROMBIN III CONCENTRATE; BLOOD CLOTTING FACTOR 10 ANTIBODY; BLOOD CLOTTING FACTOR 10A ANTIBODY; HEPARIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A INHIBITOR;

ADOLESCENT; ADULT; ANTICOAGULATION; ARTERY THROMBOSIS; ARTICLE; BLEEDING; CHILD; COHORT ANALYSIS; FEMALE; HUMAN; INFANT; INTRACARDIAC THROMBOSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; THROMBOSIS; VEIN THROMBOSIS; ACUTE DISEASE; BLOOD; DOSE RESPONSE; NEWBORN; PARTIAL THROMBOPLASTIN TIME;

ACUTE DISEASE; ANTICOAGULANTS; ANTITHROMBIN III; ANTITHROMBINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FACTOR XA INHIBITORS; HEPARIN; HUMANS; INFANT; INFANT, NEWBORN; PARTIAL THROMBOPLASTIN TIME; THROMBOSIS;

EID: 84940453887     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2015.06.006     Document Type: Article

References (22)

1. J. Hirsh, S.S. Anand, J.L. Halperin, and V. Fuster Mechanism of action and pharmacology of unfractionated heparin Arterioscler Thromb Vasc Biol 21 2001 1094 1096
2. P. Monagle, A.K. Chan, N.A. Goldenberg, R.N. Ichord, J.M. Journeyceke, U. Nowak-Gottl, et al. American College of Chest Physicians Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines Chest 141 2012 e737S e801S
3. M.R. Williams, A.B. D'Ambra, J.R. Beck, T.B. Spanier, D.L. Morales, D.N. Helman, and et al. A randomized trial of antithrombin concentrate for treatment of heparin resistance Ann Thorac Surg 70 2000 873 877
4. J.H. Lemmer Jr., and G.J. Despotis Antithrombin concentrate to treat heparin resistance in patients undergoing cardiac surgery J Thorac Cardiovasc Surg 123 2002 213 217
5. M.S. Avidan, J.H. Levy, H. van Aken, R.O. Feneck, R.D. Latimer, E. Ott, and et al. Recombinant human antithrombin III restores heparin responsiveness and decreases activation of coagulation in heparin-resistant patients during cardiopulmonary bypass J Thorac Cardiovasc Surg 130 2005 107 113
6. P. Monagle Anticoagulation in the young Heart 90 2004 808 812
7. T.M. Giglia, M.P. Massicotte, J.S. Tweddell, R.J. Barst, M. Bauman, C.C. Erickson, and et al. Prevention and treatment of thrombosis in pediatric and congenital heart disease: a scientific statement from the American Heart Association Circulation 128 2013 2622 2703
8. T.E. Wong, Y.S. Huang, J. Weiser, T.V. Brogan, S.S. Shah, and C.M. Witmer Antithrombin concentrate use in children: a multicenter cohort study J Pediatr 163 2013 1329 1334
9. L.G. Mitchell, N.A. Goldenberg, C. Male, G. Kenet, P. Monagle, U. Nowak-Göttl on behalf of the Perinatal and Paediatric Hemostasis Subcommittee of the SSC of the ISTH Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children J Thromb Haemost 9 2011 1856 1858
10. C. Kozul, F. Newall, P. Monagle, E. Mertyn, and V. Ignajatovic A clinical audit of antithrombin concentrate use in a tertiary pediatric center J Paediatr Child Health 48 2012 681 684
11. L.M. Ryerson, M.E. Bauman, S. Kuhle, A.A. Bruce, and M.P. Massicotte Antithrombin concentrate in pediatric patients requiring unfractionated heparin anticoagulation: a retrospective cohort study Pediatr Crit Care Med 15 2014 e340 e346
12. L.M. Ryerson, A.K. Bruce, L. Lequier, S. Kuhle, M.P. Massicotte, and M.E. Bauman Administration of antithrombin concentrate in infants and children on extracorporeal life support improves anticoagulation efficacy ASAIO J 60 2014 559 563
13. Thrombate (human antithrombin III) [package insert]. North Carolina, USA; Grifols Therapeutics Inc.: Published August 2013. http://www.talecris-pi.info/inserts/thrombate.pdf. Accessed January 12, 2015.
14. D. Bassler, D. Millar, and B. Schmidt Antithrombin for respiratory distress syndrome in preterm infants Cochrane Database Syst Rev 4 2006 Oct 18 CD005383 Review
15. M.S. O'Reilly Antiangiogenic antithrombin Semin Thromb Hemost 33 2007 660 666
16. M. Andrew, V. Marzinotto, P. Massicotte, V. Blanchette, J. Ginsberg, P. Brill-Edwards, and et al. Heparin therapy in pediatric patients: a prospective cohort study Pediatr Res 35 1994 78 83
17. S. Kuhle, P. Eulmesekian, B. Kavanagh, P. Massicotte, P. Vegh, and L.G. Mitchell A clinically significant incidence of bleeding in critically ill children receiving therapeutic doses of unfractionated heparin: a prospective cohort study Hematologica 92 2007 244 247
18. T. Schechter, Y. Finkelstein, W.H. Kahr, S. Williams, A.K. Chan, G. Deveber, and et al. Unfractionated heparin dosing in young infants: clinical outcomes in a cohort monitored with anti-factor Xa levels J Thromb Haemost 10 2012 368 374
19. R.S. Schwartz, K.A. Bauer, R.D. Rosenberg, E.J. Kavanaugh, D.C. Davies, and D.A. Boddanoff Clinical experience with antithrombin III concentrate in treatment of congenital and acquired deficiency of antithrombin Am J Med 87 1989 53S 60S
20. D. Collen, J. Schetz, F. de Cock, E. Holmer, and M. Verstraete Metabolism of antithrombin III (heparin cofactor) in man: effects of venous thrombosis and of heparin administration Eur J Clin Invest 7 1977 27 35
21. A. Vieira, L. Berry, F. Ofosu, and M. Andrew Heparin sensitivity and resistance in the neonate: an explanation Thromb Res 63 1991 85 98
22. M. Andrew, and B. Schmidt The use of heparin in newborn infants Semin Thromb Hemost 14 1988 28 32