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Volumn 22, Issue , 2015, Pages S19-S28

Targeted therapy in HER2-positive metastatic breast cancer: A review of the literature

Author keywords

HER2; Metastatic breast cancer; Phase III trials; Targeted therapy

Indexed keywords

ANASTROZOLE; ANTHRACYCLINE; CAPECITABINE; CARBOPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; LAPATINIB; LETROZOLE; NAVELBINE; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; TYROSINE KINASE RECEPTOR;

EID: 84940397123     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.22.2363     Document Type: Review
Times cited : (39)

References (41)
  • 1
    • 70450190156 scopus 로고    scopus 로고
    • Toronto, ON: Canadian Cancer Society; 2013
    • Canadian Cancer Society's Advisory Committee on Cancer Statistics. Canadian Cancer Statistics 2013. Toronto, ON: Canadian Cancer Society; 2013.
    • Canadian Cancer Statistics 2013
  • 2
    • 0025359146 scopus 로고
    • Expression of the her-2/neu proto-oncogene in normal human adult and fetal tissues
    • Press MF, Cordon-Cardo C, Slamon DJ. Expression of the her-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990;5:953-62.
    • (1990) Oncogene , vol.5 , pp. 953-962
    • Press, M.F.1    Cordon-Cardo, C.2    Slamon, D.J.3
  • 3
    • 66249091930 scopus 로고    scopus 로고
    • The her-2 receptor and breast cancer: Ten years of targeted anti-her-2 therapy and personalized medicine
    • Ross JS, Slodkowska EA, Symmans WF, Pusztai L, Ravdin PM, Hortobagyi GN. The her-2 receptor and breast cancer: ten years of targeted anti-her-2 therapy and personalized medicine. Oncologist 2009;14:320-68.
    • (2009) Oncologist , vol.14 , pp. 320-368
    • Ross, J.S.1    Slodkowska, E.A.2    Symmans, W.F.3    Pusztai, L.4    Ravdin, P.M.5    Hortobagyi, G.N.6
  • 4
    • 33745828702 scopus 로고    scopus 로고
    • Egf-ErbB signalling: Towards the systems level
    • Citri A, Yarden Y. egf-ErbB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006;7:505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 6
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the her-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, Mc-Guire WL. Human breast cancer: correlation of relapse and survival with amplification of the her-2/neu oncogene. Science 1987;235:177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    Mc-Guire, W.L.6
  • 8
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H, Yerushalmi R, Woods R, et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol 2010;28:3271-7.
    • (2010) J Clin Oncol , vol.28 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 9
    • 84887029181 scopus 로고    scopus 로고
    • Prognosis of metastatic breast cancer subtypes: The hormone receptor/ HER2-positive subtype is associated with the most favorable outcome
    • Lobbezoo DJ, van Kampen RJ, Voogd AC, et al. Prognosis of metastatic breast cancer subtypes: the hormone receptor/ HER2-positive subtype is associated with the most favorable outcome. Breast Cancer Res Treat 2013;141:507-14.
    • (2013) Breast Cancer Res Treat , vol.141 , pp. 507-514
    • Lobbezoo, D.J.1    van Kampen, R.J.2    Voogd, A.C.3
  • 10
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 11
    • 33745530224 scopus 로고    scopus 로고
    • Randomized phase iii study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with her-2-overexpressing metastatic breast cancer
    • Robert N, Leyland-Jones B, Asmar L, et al. Randomized phase iii study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with her-2-overexpressing metastatic breast cancer. J Clin Oncol 2006;24:2786-92.
    • (2006) J Clin Oncol , vol.24 , pp. 2786-2792
    • Robert, N.1    Leyland-Jones, B.2    Asmar, L.3
  • 12
    • 34548178720 scopus 로고    scopus 로고
    • Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
    • Burstein HJ, Keshaviah A, Baron AD, et al. Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: the trastuzumab and vinorelbine or taxane study. Cancer 2007;110:965-72.
    • (2007) Cancer , vol.110 , pp. 965-972
    • Burstein, H.J.1    Keshaviah, A.2    Baron, A.D.3
  • 13
    • 79951974161 scopus 로고    scopus 로고
    • Phase iii randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The hernata study
    • Andersson M, Lidbrink E, Bjerre K, et al. Phase iii randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: the hernata study. J Clin Oncol 2011;29:264-71.
    • (2011) J Clin Oncol , vol.29 , pp. 264-271
    • Andersson, M.1    Lidbrink, E.2    Bjerre, K.3
  • 14
    • 79951982754 scopus 로고    scopus 로고
    • Multicenter phase iii randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (bcirg 007 study): Two highly active therapeutic regimens
    • Valero V, Forbes J, Pegram MD, et al. Multicenter phase iii randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (bcirg 007 study): two highly active therapeutic regimens. J Clin Oncol 2011;29:149-56.
    • (2011) J Clin Oncol , vol.29 , pp. 149-156
    • Valero, V.1    Forbes, J.2    Pegram, M.D.3
  • 16
    • 84880452171 scopus 로고    scopus 로고
    • Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer
    • Guan Z, Xu B, DeSilvio ML, et al. Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer. J Clin Oncol 2013;31:1947-53.
    • (2013) J Clin Oncol , vol.31 , pp. 1947-1953
    • Guan, Z.1    Xu, B.2    DeSilvio, M.L.3
  • 18
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen J Jr, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-46.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.2    Pivot, X.3
  • 19
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase iii tandem study
    • Kaufman B, Mackey JR, Clemens MR, et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase iii tandem study. J Clin Oncol 2009;27:5529-37.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 20
    • 84856319982 scopus 로고    scopus 로고
    • Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the electra trial
    • Huober J, Fasching PA, Barsoum M, et al. Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the electra trial. Breast 2012;21:27-33.
    • (2012) Breast , vol.21 , pp. 27-33
    • Huober, J.1    Fasching, P.A.2    Barsoum, M.3
  • 22
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 study
    • von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: a German Breast Group 26/Breast International Group 03-05 study. J Clin Oncol 2009;27:1999-2006.
    • (2009) J Clin Oncol , vol.27 , pp. 1999-2006
    • von Minckwitz, G.1    du Bois, A.2    Schmidt, M.3
  • 23
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010;28:1124-30.
    • (2010) J Clin Oncol , vol.28 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 25
    • 84899992665 scopus 로고    scopus 로고
    • Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (bolero-3): A randomised, double-blind, placebocontrolled phase 3 trial
    • André F, O'Regan R, Ozguroglu M, et al. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (bolero-3): a randomised, double-blind, placebocontrolled phase 3 trial. Lancet Oncol 2014;15:580-91.
    • (2014) Lancet Oncol , vol.15 , pp. 580-591
    • André, F.1    O'Regan, R.2    Ozguroglu, M.3
  • 26
    • 84864066561 scopus 로고    scopus 로고
    • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: Final results from the EGF104900 study
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 study. J Clin Oncol 2012;30:2585-92.
    • (2012) J Clin Oncol , vol.30 , pp. 2585-2592
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 27
    • 79958765919 scopus 로고    scopus 로고
    • Pi3k pathway activation results in low efficacy of both trastuzumab and lapatinib
    • Wang L, Zhang Q, Zhang J, et al. pi3k pathway activation results in low efficacy of both trastuzumab and lapatinib. BMC Cancer 2011;11:248.
    • (2011) BMC Cancer , vol.11 , pp. 248
    • Wang, L.1    Zhang, Q.2    Zhang, J.3
  • 28
    • 77957771125 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in women with her-2-positive advanced breast cancer: Final survival analysis of a phase iii randomized trial
    • Cameron D, Casey M, Oliva C, Newstat B, Imwalle B, Geyer CE. Lapatinib plus capecitabine in women with her-2-positive advanced breast cancer: final survival analysis of a phase iii randomized trial. Oncologist 2010;15:924-34.
    • (2010) Oncologist , vol.15 , pp. 924-934
    • Cameron, D.1    Casey, M.2    Oliva, C.3    Newstat, B.4    Imwalle, B.5    Geyer, C.E.6
  • 30
    • 34247346051 scopus 로고    scopus 로고
    • Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer
    • Gabos Z, Sinha R, Hanson J, et al. Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer. J Clin Oncol 2006;24:5658-63.
    • (2006) J Clin Oncol , vol.24 , pp. 5658-5663
    • Gabos, Z.1    Sinha, R.2    Hanson, J.3
  • 32
    • 70449698237 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases
    • Leyland-Jones B. Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases. J Clin Oncol 2009;27:5278-86.
    • (2009) J Clin Oncol , vol.27 , pp. 5278-5286
    • Leyland-Jones, B.1
  • 33
    • 56549113680 scopus 로고    scopus 로고
    • A phase iii randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
    • Cameron D, Casey M, Press M, et al. A phase iii randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008;112:533-43.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 533-543
    • Cameron D, Casey M, Press M, et al.,1
  • 34
    • 84871722407 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (landscape): A single-group phase 2 study
    • Bachelot T, Romieu G, Campone M, et al. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (landscape): a single-group phase 2 study. Lancet Oncol 2013;14:64-71.
    • (2013) Lancet Oncol , vol.14 , pp. 64-71
    • Bachelot, T.1    Romieu, G.2    Campone, M.3
  • 35
    • 84905859056 scopus 로고    scopus 로고
    • Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology clinical practice guideline
    • Ramakrishna N, Temin S, Chandarlapaty S, et al. Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2014;32:2100-8.
    • (2014) J Clin Oncol , vol.32 , pp. 2100-2108
    • Ramakrishna, N.1    Temin, S.2    Chandarlapaty, S.3
  • 36
    • 84911926434 scopus 로고    scopus 로고
    • Biomarker analyses in cleopatra: A phase iii, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer
    • Baselga J, Cortes J, Im SA, et al. Biomarker analyses in cleopatra: a phase iii, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer. J Clin Oncol 2014;32:3753-61.
    • (2014) J Clin Oncol , vol.32 , pp. 3753-3761
    • Baselga, J.1    Cortes, J.2    Im, S.A.3
  • 38
    • 84874343465 scopus 로고    scopus 로고
    • Drug-conjugated antibodies for the treatment of cancer
    • Lambert JM. Drug-conjugated antibodies for the treatment of cancer. Br J Clin Pharmacol 2013;76:248-62.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 248-262
    • Lambert, J.M.1
  • 39
    • 84873053339 scopus 로고    scopus 로고
    • Antibody-drug conjugates in cancer therapy
    • Sievers EL, Senter PD. Antibody-drug conjugates in cancer therapy. Annu Rev Med 2013;64:15-29.
    • (2013) Annu Rev Med , vol.64 , pp. 15-29
    • Sievers, E.L.1    Senter, P.D.2
  • 40
    • 84915751470 scopus 로고    scopus 로고
    • Preclinical profile of the HER2-targeting adc SYD983/SYD985: Introduction of a new duocarmycin-based linker-drug platform
    • Dokter W, Ubink R, van der Lee M, et al. Preclinical profile of the HER2-targeting adc SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform. Mol Cancer Ther 2014;13:2618-29.
    • (2014) Mol Cancer Ther , vol.13 , pp. 2618-2629
    • Dokter, W.1    Ubink, R.2    van der Lee, M.3
  • 41
    • 84940426652 scopus 로고    scopus 로고
    • Toward clinical development of SYD985, a novel HER2-targeting antibody-drug conjugate (adc) [abstract 626]
    • [Available online at: cited November 11, 2014]
    • Verheijden G, Beusker P, Ubink R, et al. Toward clinical development of SYD985, a novel HER2-targeting antibody-drug conjugate (adc) [abstract 626]. J Clin Oncol 2014;32(suppl):. [Available online at: http://meetinglibrary.asco.org/ content/131605-144; cited November 11, 2014]
    • (2014) J Clin Oncol , vol.32
    • Verheijden, G.1    Beusker, P.2    Ubink, R.3


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