Maximizing predictability of a bottom-up complex multi-scale model through systematic validation and multi-objective multi-level optimization

International IEEE/EMBS Conference on Neural Engineering, NER

Volumn 2015-July, Issue , 2015, Pages 300-303

  Bouteiller, Jean Marie C ^a   Feng, Zhuobo ^a   Onopa, Alexander ^a   Huang, Mike ^e   Hu, Eric Y ^a   Somogyi, Endre ^b   Baudry, Michel ^c   Bischoff, Serge ^d   Berger, Theodore W ^a  

^a DRB Building ^*  (United States)

^b INDIANA UNIVERSITY   (United States)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^d Rhenovia Pharma   (France)

^e Rhenovia Pharma ^*

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX NETWORKS; ITERATIVE METHODS;

COMPUTATIONAL MODEL; DESIGN IMPLEMENTATION; FUNCTIONAL LEVELS; LEVEL OF PREDICTABILITIES; MATHEMATICAL REPRESENTATIONS; MULTI-SCALE MODELING; MULTILEVEL OPTIMIZATION; SYSTEM'S DYNAMICS;

BIOLOGICAL SYSTEMS;

EID: 84940382230     PISSN: 19483546     EISSN: 19483554     Source Type: Conference Proceeding    
DOI: 10.1109/NER.2015.7146619     Document Type: Conference Paper

References (10)

1. E. M. Izhikevich, "Simple model of spiking neurons., " IEEE Trans. Neural Netw., vol. 14, no. 6, pp. 1569-72, Jan. 2003.
2. N. L. Golding, W. L. Kath, and N. Spruston, "Dichotomy of Action-Potential Backpropagation in CA1 Pyramidal Neuron Dendrites, " J. Neurophysiol., vol. 86, no. 6, pp. 2998-3010, Dec. 2001.
3. H. M. Sauro, T. T. Karlsson, M. Swat, M. Galdzicki, and A. Somogyi, "libRoadRunner: A High Performance SBML Compliant Simulator, " bioRxiv, Dec. 2013.
4. K. Deb, Multi-Objective Optimization Using Evolutionary Algorithms, vol. 16. John Wiley and Sons, 2001, p. 497.
5. A. Bahl, M. B. Stemmler, A. V. M. Herz, and A. Roth, "Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data., " J. Neurosci. Methods, vol. 210, no. 1, pp. 22-34, Sep. 2012.
6. W. Zhang, J. R. Howe, and G. K. Popescu, "Distinct gating modes determine the biphasic relaxation of NMDA receptor currents., " Nat. Neurosci., vol. 11, no. 12, pp. 1373-5, Dec. 2008.
7. D. Song, V. Z. Marmarelis, and T. W. Berger, "Parametric and nonparametric modeling of short-term synaptic plasticity. Part I: Computational study., " J. Comput. Neurosci., vol. 26, no. 1, pp. 1-19, Feb. 2009.
8. D. Song, Z. Wang, V. Z. Marmarelis, and T. W. Berger, "Parametric and non-parametric modeling of short-term synaptic plasticity. Part II: Experimental study., " J. Comput. Neurosci., vol. 26, no. 1, pp. 21-37, Feb. 2009.
9. N. Le Novere, D. Waltemath, F. Bergmann, and R. Adams, "Simulation Experiment Description Markup Language (SEDML) : Level 1 Version 1, " Nat. Preced., Mar. 2011.
10. D. Huizinga and A. Kolawa, Automated Defect Prevention. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007.