The effects of 40 and 80 mg hydro- alcoholic extract of crocus sativus in the treatment of mild to moderate depression

Journal of Mazandaran University of Medical Sciences

Volumn 24, Issue 113, 2014, Pages 47-53

  Moosavi, Seyed Mohammad ^a   Ahmadi, Mahshid ^a   Amini, Mojgan ^a   Vazirzadeh, Bita ^b  

^a MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Tasalli Saffron Company   (Iran)

Author keywords

Crocus sativus; Depression; Fluoxetine

Indexed keywords

CROCUS SATIVUS EXTRACT; FLUOXETINE;

ARTICLE; COMPARATIVE EFFECTIVENESS; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG EFFICACY; DSM-IV; HAMILTON SCALE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL;

EID: 84940301067     PISSN: 17359279     EISSN: 17359260     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Sadock BJ, Sadock AS. Synopsis of Psychiatry and Behavioral Science. 10th ed. Volume 1. Williams & Wilkins; 2007. p. 527-530.
2. De Semet PAGM, Nolen WA. John's Worth as an Antidepressants. Br Med J 1996; 313: 241-242.
3. Dadkhah M, Ehtesham M, Fekrat H. Iranian saffron an unknown gem. 2nd ed. Tehran: Shahrashoob; 2010. p. 7.
4. Akhondzadeh Basti A, Moshiri E, Noorbala AA, Jamshidi AH, Abbasi SH, Akhondzadeh S. Comparison of Petal of Corcus Sativus and Fluoxetine in the Treatment of Depressed Outpatients: A Pilot Double-blind Randomized Trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-442.
5. Noorbala AA, Akhondzadeh S, Tahmacebipour N, Jamshidi AH Hydro-alcoholic Extract of Corcus sativus Versus Fluoxetine in the Treatment of Mild to Moderate Depression: A Double-blind, Randomized Pilot Trial. J Ethnopharmacol 2005; 97(2): 281-284.
6. Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 2006; 13(9-10): 607-611.
7. Akhondzadeh S, Fallah-Pour H, Afkham H, Jamshidi AH, Khalighi C, Igaroudi F. Comparison of Corcus Sativus and Imipramine in the Treatment of Mild to Moderate Depression: A Pilot Double-blind Randomized Trial. BMC Complement Altern Med 2004; 4: 12.
8. MasinaeiNezhad Z, Abdullahi Mohammad A, Hashemi Bonjar Z, Assadi Bidmeshki E, Arbabi S, Rahnama M. Effect of Corcus Sativus (Saffron) on Depression among Students of zabol Faculty of Medical Science. Journal of the Neurological Sciences 2005; 238: 516-517.
9. Wang Y, Han T, Zhu Y, Zheng CJ, Ming QL, Rahman K, et al. Antidepressant Properties of Bioactive Fractions from the Extract of Corcus Sativus L. J Nat Med 2010; 64(1): 24-30.
10. Hosseinzadeh H, Motamedshariati V, Hadizadeh H. Antidepressant Effect of Kaempferol, A Constituent of Saffron (Corcus Sativus) petal, in Mice and rats. Pharmacologyonline 2007; 2: 367-370.
11. Agha-Hosseini M, Kashani L, Aleyaseen A, Ghoreishi A, Rahmanpour H, Zarrinara AR, et al. Crocus Sativus (Saffron) in the Treatment of Premenstrual Syndrome: A Double-blind, Randomised and Placebo-controlled Trial. BJOG 2008; 115(4): 515-519.
12. Akhondzadeh Basti A, Ghoreishi SA, Noorbala AA, Akhondzadeh SH, Rezazadeh SH. Petal and Stigma of Crocus Sativus in the Treatment of Depression: A Pilot Double-blind Randomized Trial. Journal of Medicinal Plants 2008; 7(4): 29-36.
13. Hamilton M. A Rating Scale for Depression. J Neural Neurosurg Psychiatry 1960; 23: 56-62.
14. Bagby RM, Ryder AG, Schuller DR, Marshal MB. The Hamilton Depression Rating Scale:Has the Gold Standard Become a Lead Weight? Am J Psychiatry 2004; 161: 2163-77.
15. Hofer S, Lim L, Guyatt G, Oldrige N. The Macnew Heart Disease Health-related quality of life Instrument: A Summery. Health and Quality of life Outcomes 2004; 2, 3.