The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Ackaert, Chloé ^a   Kofler, Stefan ^a   Horejs Hoeck, Jutta ^a   Zulehner, Nora ^b   Asam, Claudia ^a   Von Grafenstein, Susanne ^c   Fuchs, Julian E ^c   Briza, Peter ^a   Liedl, Klaus R ^c   Bohle, Barbara ^b   Ferreira, Fátima ^a   Brandstetter, Hans ^a   Oostingh, Gertie J ^a,d   Duschl, Albert ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF INNSBRUCK   (Austria)

^d SALZBURG UNIVERSITY OF APPLIED SCIENCES   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; INTERLEUKIN 12; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLLEN ANTIGEN; POLLEN ANTIGEN BET V 1 0101; TETRANITROMETHANE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BET V 1 ALLERGEN, BETULA; CYTOKINE; PLANT ANTIGEN;

ALLERGENICITY; AMINO ACID ANALYSIS; ANIMAL CELL; ARTICLE; BIRCH; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOSTIMULATION; INFLAMMATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOUSE; NITRATION; NONHUMAN; OLIGOMERIZATION; POLLEN ALLERGY; POLLEN ANALYSIS; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; T LYMPHOCYTE; TH1 CELL; TH2 CELL; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; LYSOSOME; METABOLISM; MONOCYTE; POLLEN; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN MULTIMERIZATION; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, PLANT; CYTOKINES; DENDRITIC CELLS; HUMANS; LYMPHOCYTE ACTIVATION; LYSOSOMES; MODELS, MOLECULAR; MONOCYTES; POLLEN; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEOLYSIS; RHINITIS, ALLERGIC, SEASONAL; T-LYMPHOCYTE SUBSETS;

EID: 84940274376     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0104520     Document Type: Article

References (46)

1. Holgate ST (1999) The epidemic of allergy and asthma. Nature 402: B2-B4.
2. Saxon A, Diaz-Sanchez D (2005) Air pollution and allergy: you are what you breathe. Nat Immunol 6: 223-226. (Pubitemid 41724754)
3. Ring J, Krämer U, Schäfer T, Behrendt H (2001) Why are allergies increasing? Current Opinion in Immunology 13: 701-708. (Pubitemid 33000165)
4. D'Amato G, Cecchi L, D'Amato M, Liccardi G (2010) Urban Air Pollution and Climate Change as Environmental Risk Factors of Respiratory Allergy: An Update. J Investig Allergol Clin Immunol 20: 95-102.
5. Franze T, Weller MG, Niessner R, Poschl U (2003) Enzyme immunoassays for the investigation of protein nitration by air pollutants. Analyst 128: 824-831. (Pubitemid 36897869)
6. Franze T, Weller MG, Niessner R, Poschl U (2005) Protein nitration by polluted air. Environ Sci Technol 39: 1673-1678. (Pubitemid 40387721)
7. Bernstein JA, Alexis N, Barnes C, Bernstein IL, Nel A, et al. (2004) Health effects of air pollution. Journal of Allergy and Clinical Immunology 114: 1116-1123. (Pubitemid 39469153)
8. Ghosh S, Janocha AJ, Aronica MA, Swaidani S, Comhair SAA, et al. (2006) Nitrotyrosine Proteome Survey in Asthma Identifies Oxidative Mechanism of Catalase Inactivation. The Journal of Immunology 176: 5587-5597.
9. Ghosh S, Erzurum SC (2011) Nitric oxide metabolism in asthma pathophysiology. Biochimica et Biophysica Acta (BBA) - General Subjects 1810: 1008-1016.
10. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, et al. (1989) IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa*. Allergy 44: 385-395. (Pubitemid 19211453)
11. Gruijthuijsen YK, Grieshuber I, Stocklinger A, Tischler U, Fehrenbach T, et al. (2006) Nitration enhances the allergenic potential of proteins. Int Arch Allergy Immunol 141: 265-275. (Pubitemid 44597745)
12. Karle AC, Oostingh GJ, Mutschlechner S, Ferreira F, Lackner P, et al. (2012) Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-Derived Peptides by HLA-DR on Human Dendritic Cells. PLoS ONE 7: e31483.
13. Koide S, Sidhu SS (2009) The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins. ACS Chemical Biology 4: 325-334.
14. Radi R (2012) Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects. Accounts of Chemical Research 46: 550-559.
15. Hoffmann-Sommergruber K, Susani M, Ferreira F, Jertschin P, Ahorn H, et al. (1997) High-level expression and purification of the major birch pollen allergen, Bet v 1. Protein Expr Purif 9: 33-39. (Pubitemid 27335468)
16. Riordan JF, Sokolovsky M, Vallee BL (1967) Environmentally sensitive tyrosyl residues. Nitration with tetranitromethane. Biochemistry 6: 358-361.
17. Jahn-Schmid B, Radakovics A, Lüttkopf D, Scheurer S, Vieths S, et al. (2005) Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. Journal of Allergy and Clinical Immunology 116: 213-219. (Pubitemid 40909770)
18. Egger M, Jürets A, Wallner M, Briza P, Ruzek S, et al. (2011) Assessing Protein Immunogenicity with a Dendritic Cell Line-Derived Endolysosomal Degradome. PLoS ONE 6: e17278.
19. Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. The Journal of Experimental Medicine 179: 1109-1118.
20. Bergfors T (2003) Seeds to crystals. Journal of Structural Biology 142: 66-76.
21. Collaborative Computational Project N (1994) The CCP4 Suite: Programs for Protein Crystallography. Acta Cryst D50: 760-763.
22. McCoy A (2007) Solving structures of protein complexes by molecular replacement with Phaser. Acta Crystallographica Section D 63: 32-41.
23. Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, et al. (2012) Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1. Journal of Molecular Biology 422: 109-123.
24. Murshudov GN, Skubak P, Lebedev AA, Pannu NS, Steiner RA, et al. (2011) REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallographica Section D 67: 355-367.
25. Emsley P, Lohkamp B, Scott WG, Cowtan K (2010) Features and development of Coot. Acta Crystallographica Section D 66: 486-501.
26. DeLano WL (2005) The case for open-source software in drug discovery. Drug Discovery Today 10: 213-217.
27. Chen VB, Arendall WB III, Headd JJ, Keedy DA, Immormino RM, et al. (2010) MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallographica Section D 66: 12-21.
28. Weichenberger CX, Sippl MJ (2007) NQ-Flipper: recognition and correction of erroneous asparagine and glutamine side-chain rotamers in protein structures. Nucleic Acids Research 35: W403-W406.
29. Laskowski RA, Moss DS, Thornton JM (1993) Main-chain Bond Lengths and Bond Angles in Protein Structures. Journal of Molecular Biology 231: 1049-1067. (Pubitemid 23209879)
30. Case D, Darden TTE. Cheatham I, Simmerling C, Wang J, et al. (2010) AMBER11 and AmberTools version 1.5. University of California, San Francisco
31. Hornak V, Abel R, Okur A, Strockbine B, Roitberg A, et al. (2006) Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins: Structure, Function, and Bioinformatics 65: 712-725. (Pubitemid 44583220)
32. Myung Y, Han S (2010) Field Parameters for 3-Nitrotyrosine and 6-Nitrotryptophan. Bulletin of the Korean Chemical Society 31: 2581-2587.
33. Wallnoefer HG, Lingott T, Gutiérrez JM, Merfort I, Liedl KR (2010) Backbone Flexibility Controls the Activity and Specificity of a Protein-Protein Interface: Specificity in Snake Venom Metalloproteases. Journal of the American Chemical Society 132: 10330-10337.
34. Delamarre L, Couture R, Mellman I, Trombetta ES (2006) Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis. The Journal of Experimental Medicine 203: 2049-2055. (Pubitemid 44352226)
35. Paul WE, Zhu J (2010) How are TH2-type immune responses initiated and amplified? Nat Rev Immunol 10: 225-235.
36. Eiwegger T, Mayer E, Brix S, Schabussova I, Dehlink E, et al. (2008) Allergen specific responses in cord and adult blood are differentially modulated in the presence of endotoxins. Clinical & Experimental Allergy 38: 1627-1634.
37. Shiraiwa M, Pöschl U, Knopf DA (2012) Multiphase Chemical Kinetics of NO3 Radicals Reacting with Organic Aerosol Components from Biomass Burning. Environmental Science & Technology 46: 6630-6636.
38. Alvarez B, Radi R (2003) Peroxynitrite reactivity with amino acids and proteins. Amino Acids 25: 295-311. (Pubitemid 38041267)
39. Zaborsky N, Brunner M, Wallner M, Himly M, Karl T, et al. (2010) Antigen Aggregation Decides the Fate of the Allergic Immune Response. The Journal of Immunology 184: 725-735.
40. Vrtala S, Hirtenlehner K, Susani M, Akdis M, Kussebi F, et al. (2001) Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen, Bet v 1. The FASEB Journal.
41. Schöll I, Kalkura N, Shedziankova Y, Bergmann A, Verdino P, et al. (2005) Dimerization of the Major Birch Pollen Allergen Bet v 1 Is Important for its In Vivo IgE-Cross-Linking Potential in Mice. The Journal of Immunology 175: 6645-6650. (Pubitemid 41598907)
42. Ilyinskii PO, Thoidis G, Sherman MY, Shneider A (2008) Adjuvant potential of aggregate-forming polyglutamine domains. Vaccine 26: 3223-3226.
43. Mahler H-C, Friess W, Grauschopf U, Kiese S (2009) Protein aggregation: Pathways, induction factors and analysis. Journal of Pharmaceutical Sciences 98: 2909-2934.
44. Kiese S, Papppenberger A, Friess W, Mahler H-C (2008) Shaken, not stirred: Mechanical stress testing of an IgG1 antibody. Journal of Pharmaceutical Sciences 97: 4347-4366.
45. Rosenberg A (2006) Effects of protein aggregates: An immunologic perspective. The AAPS Journal 8: E501-E507.
46. Kofler S, Ackaert C, Samonig M, Asam C, Briza P, et al. (2014) Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties. Journal of Biological Chemistry 289: 540-551.