Thrombolytic treatment decreases glutamate/ GABA ratio in serum during acute ischaemic stroke: A pilot study

Neurological Research

Volumn 37, Issue 10, 2015, Pages 934-937

  Kurzepa, Jacek ^a   Szpetnar, Maria ^a   Hordyjewska, Anna ^a   Waątroba, Sławomir ^a   Gołąb, Piotr ^b   Boguszewska Czubara, Anna ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b Department of Internal Medicine ^*  (Poland)

Author keywords

GABA; Glutamate; rtPA; Stroke

Indexed keywords

4 AMINOBUTYRIC ACID; ALTEPLASE; GLUTAMIC ACID; FIBRINOLYTIC AGENT; GLUTAMIC ACID DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MALE; BLOOD; PILOT STUDY; STROKE; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; FIBRINOLYTIC AGENTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMATES; HUMANS; MALE; PILOT PROJECTS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84940177872     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132815Y.0000000049     Document Type: Article

References (16)

1. 1 Lee G, Yin CS, Choi S, Choi S, Yang J, Lee H. Acupuncture attenuates extracellular glutamate level in global ischemia model of rat. Neurol Res. 2010;32(Suppl 1):79–83
2. 2 Castillo J, Rodriguez I. Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc Dis. 2004;17(Suppl 1):7–18
3. 3 Liu J, Wang L. Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. Cochrane Database Syst Rev. 2014; 8:CD009622
4. 4 Chi OZ, Hunter C, Liu X, Chi Y, Weiss HR. Effects of GABA(A) receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia. J Neurol Sci. 2011;301:66–70
5. 5 Cai H, Zhu R, Li H, Zhang X, Hu L, Yang W. Elevated plasma c-aminobutyrate/glutamate ratio and responses to risperidone antipsychotic treatment in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1273–38
6. 6 Luo J, Min S, Wei K, Li P, Dong J, Liu Y. Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats. J Anesth. 2011;25:657–65
7. 7 Gross H, Sung G, Weingart SD, Smith WS. Emergency neurological life support: acute ischemic stroke. Neurocrit Care. 2012;17(Suppl 1):S29–S36
8. 8 McMahon B, Kwaan HC. The plasminogen activator systemand cancer. Pathophysiol Haemost Thromb. 2008;36:184–94
9. 9 Golab P, Kielbus M, Bielewicz J, Kurzepa J. The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro. Neurol Res. 2015;37:9–13
10. 10 Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A, Licata G. Inflammation in ischemic stroke subtypes. Curr Pharm Des. 2012;18:4289–310
11. 11 Tuttolomondo A, Di Raimondo D, Forte GI, Casuccio A, Vaccarino L, Scola L. Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke in relation to TOAST subtype. Cytokine. 2012;58:398–405
12. 12 Pinto A, Tuttolomondo A, Casuccio A, Di Raimondo D, Di Sciacca R, Arnao V. Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF). Clin Sci (Lond). 2009;116:781–9
13. 13 Castellanos M, Sobrino T, Pedraza S, Moldes O, Pumar JM, Silva Y. High plasma glutamate concentrations are associated with infarct growth in acute ischemic stroke. Neurology. 2008;71:1862–8
14. 14 Lang D, Kiewert C, Mdzinarishvili A, Schwarzkopf TM, Sumbria R, Hartmann J. Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo. Brain Res. 2011;1425:155–63
15. 15 Zhang F, Li C, Wang R, Han D, Zhang Q, Zhou C. Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience. 2007;150: 938–49
16. 16 Ramanathan M, Babu CS, Justin A, Shanthakumari S. Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats. Indian J Exp Biol. 2012;50:391–7.