Refractory atypical hemolytic uremic syndrome with monoclonal gammopathy responsive to bortezomib-based therapy

Clinical Nephrology

Volumn 83, Issue 6, 2015, Pages 363-369

  Cheungpasitporn, Wisit ^a   Leung, Nelson ^a   Sethi, Sanjeev ^a   Gertz, Morie A ^a   Fervenza, Fernando C ^a  

^a MAYO CLINIC   (United States)

Author keywords

Atypical hemolytic uremic syndrome (aHUS); Bortezomib; Monoclonal gammopathy

Indexed keywords

ALBUMIN; BENAZEPRIL; BORTEZOMIB; COMPLEMENT COMPONENT C3; COMPLEMENT MEMBRANE ATTACK COMPLEX; CREATININE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; ECULIZUMAB; FIBRIN DEGRADATION PRODUCT; HAPTOGLOBIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LACTATE DEHYDROGENASE; LENALIDOMIDE; LOSARTAN; PREDNISONE; ANTIBODIES, MONOCLONAL, HUMANIZED; BORONIC ACIDS; PYRAZINES;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD TRANSFUSION; BONE MARROW BIOPSY; CASE REPORT; COMPLEMENT DEPOSITION; CREATININE BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; DYSPNEA; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENERALIZED EDEMA; GENETIC SCREENING; GLOMERULUS CAPILLARY; HEMOLYTIC ANEMIA; HEMOLYTIC UREMIC SYNDROME; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; LABORATORY TEST; LEG EDEMA; LEUKOPENIA; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MIDDLE AGED; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NEPHROTIC SYNDROME; PROTEINURIA; REMISSION; SKIN TINGLING; TREATMENT OUTCOME; ACUTE KIDNEY INJURY; ATYPICAL HEMOLYTIC UREMIC SYNDROME; HUMANS; PARAPROTEINEMIAS;

ACUTE KIDNEY INJURY; ANTIBODIES, MONOCLONAL, HUMANIZED; ATYPICAL HEMOLYTIC UREMIC SYNDROME; BORONIC ACIDS; HUMANS; MALE; MIDDLE AGED; PARAPROTEINEMIAS; PYRAZINES;

EID: 84940108964     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CN108363     Document Type: Article

References (30)

1. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009; 361: 1676-1687. CrossRef PubMed
2. Karmali MA, Steele BT, Petric M, Lim C. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet. 1983; 1: 619-620. CrossRef PubMed
3. Tarr PI, Gordon CA, Chandler WL. Shiga-toxinproducing Escherichia coli and haemolytic uraemic syndrome. Lancet. 2005; 365: 1073-1086. PubMed
4. Waters AM, Licht C. aHUS caused by complement dysregulation: new therapies on the horizon. Pediatr Nephrol. 2011; 26: 41-57. CrossRef PubMed
5. Sallée M, Ismail K, Fakhouri F, Vacher-Coponat H, Moussi-Francés J, Frémaux-Bacchi V, Burtey S. Thrombocytopenia is not mandatory to diagnose haemolytic and uremic syndrome. BMC Nephrol. 2013; 14: 3. CrossRef PubMed
6. Gnappi E, Allinovi M, Vaglio A, Bresin E, Sorosina A, Pilato FP, Allegri L, Manenti L. Membranoproliferative glomerulonephritis, atypical hemolytic uremic syndrome, and a new complement factor H mutation: report of a case. Pediatr Nephrol. 2012; 27: 1995-1999. CrossRef PubMed
7. Jha V, Murthy MS, Kohli HS, Sud K, Gupta KL, Joshi K, Sakhuja V. Secondary membranoproliferative glomerulonephritis due to hemolytic uremic syndrome: an unusual presentation. Ren Fail. 1998; 20: 845-850. CrossRef PubMed
8. Vaziri-Sani F, Holmberg L, Sjöholm AG, Kristoffersson AC, Manea M, Frémeaux-Bacchi V, Fehrman-Ekholm I, Raafat R, Karpman D. Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome. Kidney Int. 2006; 69: 981-988. CrossRef PubMed
9. Boyer O, Noël LH, Balzamo E, Guest G, Biebuyck N, Charbit M, Salomon R, Frémeaux-Bacchi V, Niaudet P. Complement factor H deficiency and posttransplantation glomerulonephritis with isolated C3 deposits. Am J Kidney Dis. 2008; 51: 671-677. CrossRef PubMed
10. Lorcy N, Rioux-Leclercq N, Lombard ML, Le Pogamp P, Vigneau C. Three kidneys, two diseases, one antibody? Nephrol Dial Transplant. 2011; 26: 3811-3813. CrossRef PubMed
11. Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D. Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. Nephrol Dial Transplant. 2011; 26: 3399-3403. CrossRef PubMed
12. Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group. Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood. 2012; 120: 4292-4295. CrossRef PubMed
13. Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF, Offord JR, Dispenzieri A, Katzmann JA, Melton LJ III. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006; 354: 1362-1369. CrossRef PubMed
14. Mache CJ, Acham-Roschitz B, Frémeaux-Bacchi V, Kirschfink M, Zipfel PF, Roedl S, Vester U, Ring E. Complement inhibitor eculizumab in atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009; 4: 1312-1316. CrossRef PubMed
15. Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C, Bingham C, Cohen DJ, Delmas Y, Douglas K, Eitner F, Feldkamp T, Fouque D, Furman RR, Gaber O, Herthelius M, Hourmant M, Karpman D, Lebranchu Y, Mariat C, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013; 368: 2169-2181. CrossRef PubMed
16. Bomback AS, Smith RJ, Barile GR, Zhang Y, Heher EC, Herlitz L, Stokes MB, Markowitz GS, D'Agati VD, Canetta PA, Radhakrishnan J, Appel GB. Eculizumab for dense deposit disease and C3 glomerulonephritis. Clin J Am Soc Nephrol. 2012; 7: 748-756. CrossRef PubMed
17. Sethi S, Rajkumar SV. Monoclonal gammopathy-associated proliferative glomerulonephritis. Mayo Clin Proc. 2013; 88: 1284-1293. CrossRef PubMed
18. Nasr SH, Satoskar A, Markowitz GS, Valeri AM, Appel GB, Stokes MB, Nadasdy T, D'Agati VD. Proliferative glomerulonephritis with monoclonal IgG deposits. J Am Soc Nephrol. 2009; 20: 2055-2064. CrossRef PubMed
19. Zand L, Kattah A, Fervenza FC, Smith RJ, Nasr SH, Zhang Y, Vrana JA, Leung N, Cornell LD, Sethi S. C3 glomerulonephritis associated with monoclonal gammopathy: a case series. Am J Kidney Dis. 2013; 62: 506-514. CrossRef PubMed
20. Sethi S, Sukov WR, Zhang Y, Fervenza FC, Lager DJ, Miller DV, Cornell LD, Krishnan SG, Smith RJ. Dense deposit disease associated with monoclonal gammopathy of undetermined significance. Am J Kidney Dis. 2010; 56: 977-982. CrossRef PubMed
21. Sethi S, Zand L, Leung N, Smith RJ, Jevremonic D, Herrmann SS, Fervenza FC. Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy. Clin J Am Soc Nephrol. 2010; 5: 770-782. CrossRef PubMed
22. Kavanagh D, Goodship T. Haemolytic uraemic syndrome. Nephron Clin Pract. 2011; 118: c37-c42. CrossRef PubMed
23. Kavanagh D, Goodship TH, Richards A. Atypical hemolytic uremic syndrome. Semin Nephrol. 2013; 33: 508-530. CrossRef PubMed
24. Suankratay C, Zhang Y, Jones D, Lint TF, Gewurz H. Enhancement of lectin pathway haemolysis by immunoglobulins. Clin Exp Immunol. 1999; 117: 435-441. CrossRef PubMed
25. Hofmeister CC, Jin M, Cataland SR, Benson DM, Wu HM. TTP disease course is independent of myeloma treatment and response. Am J Hematol. 2010; 85: 304-306. CrossRef PubMed
26. Lechner K, Obermeier HL. Cancer-related microangiopathic hemolytic anemia: clinical and laboratory features in 168 reported cases. Medicine (Baltimore). 2012; 91: 195-205. CrossRef PubMed
27. Mehta N, Saxena A, Niesvizky R. Bortezomib-induced thrombotic thrombocytopaenic purpura. BMJ Case Rep. 2012. PubMed
28. Moore H, Romeril K. Multiple myeloma presenting with a fever of unknown origin and development of thrombotic thrombocytopenic purpura post-bortezomib. Intern Med J. 2011; 41: 348-350. Cross-Ref PubMed
29. Yao H, Monge M, Renou M, Lecaque C, Jauréguy M, Presne C, Makdassi R, Choukroun G. Thrombotic thrombocytopenic purpura due to anti-ADAMTS13 antibodies in multiple myeloma. Clin Nephrol. 2014; 81: 210-215. CrossRef PubMed
30. Li CH, Ho CL. Thrombotic thrombocytopenic purpura as the initial presentation of Pneumocystis jiroveci pneumonia in an immunocompetent patient. Ann Hematol. 2007; 86: 223-224. Cross-Ref PubMed