Methicillin-resistant Staphylococcus aureus spa type t002 outbreak in horses and staff at a veterinary teaching hospital after its presumed introduction by a veterinarian

Journal of Clinical Microbiology

Volumn 53, Issue 9, 2015, Pages 2827-2831

  Steinman, Amir ^a   Masarwa, Samira ^b   Tirosh Levy, Sharon ^a   Gleser, Dan ^a   Kelmer, Gal ^a   Adler, Amos ^b   Carmeli, Yehuda ^b   Schwaber, Mitchell J ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MINISTRY OF HEALTH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM CARRIER; BACTERIUM ISOLATE; EPIDEMIC; HORSE; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; STAFF; TEACHING HOSPITAL; VETERINARIAN; ANIMAL; CLASSIFICATION; DISEASE TRANSMISSION; GENETICS; GENOTYPE; HEALTH CARE PERSONNEL; HETEROZYGOTE; HORSE DISEASES; HOSPITAL; ISOLATION AND PURIFICATION; ISRAEL; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; STAPHYLOCOCCAL INFECTIONS; TRANSMISSION; VETERINARY;

ANIMALIA; EQUIDAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS PROTEIN A;

ANIMALS; CARRIER STATE; DISEASE OUTBREAKS; DISEASE TRANSMISSION, INFECTIOUS; GENOTYPE; HEALTH PERSONNEL; HORSE DISEASES; HORSES; HOSPITALS, ANIMAL; HOSPITALS, TEACHING; HUMANS; ISRAEL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCAL PROTEIN A; VETERINARIANS;

EID: 84940093958     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00090-15     Document Type: Article

References (23)

1. Seguin JC, Walker RD, Caron JP, Kloos WE, George CG, Hollis RJ, Jones RN, Pfaller MA. 1999. Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human-to-animal transmission. J Clin Microbiol 37:1459-1463.
2. Weese JS, Archambault M, Willey BM, Dick H, Hearn P, Kreiswirth BN, Said-Salim B, McGeer A, Likhoshvay Y, Prescott JF, Low DE. 2005. Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerg Infect Dis 11:430-435. http://dx.doi.org/10.3201/eid1103.040481.
3. O'Mahony R, Abbott Y, Leonard FC, Markey BK, Quinn PJ, Pollock PJ, Fanning S, Rossney AS. 2005. Methicillin-resistant Staphylococcus aureus (MRSA) isolated from animals and veterinary personnel in Ireland. Vet Microbiol 109:285-296. http://dx.doi.org/10.1016/j.vetmic.2005.06/003.
4. Cuny C, Kuemmerle J, Stanek C, Willey B, Strommenger B, Witte W. 2006. Emergence of MRSA infections in horses in a veterinary hospital: strain characterization and comparison with MRSA from humans. Euro Surveill 11:pii=595. http://www.eurosurveillance.org/ViewArticle.aspx ?ArticleId=595.
5. Cuny C, Strommenger B, Witte W, Stanek C. 2008. Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospital. Microb Drug Resist 14:307-310. http://dx.doi.org/10.1089/mdr.2008/0845.
6. van Duijkeren E, Moleman M, Sloet van Oldruitenborgh-Oosterbaan MM, Multem J, Troelstra A, Fluit AC, van Wamel WJB, Houwers DJ, de Neeling AJ, Wagenaar JA. 2010. Methicillin-resistant Staphylococcus aureus in horses and horse personnel: an investigation of several outbreaks. Vet Microbiol 141:96-102. http://dx.doi.org/10.1016/j.vetmic/2009.08.009.
7. Sieber S, Gerber V, Jandova V, Rossano A, Evison JM, Perreten V. 2011. Evolution of multidrug-resistant Staphylococcus aureus infections in horses and colonized personnel in an equine clinic between 2005 and 2010. Microb Drug Resist 17:471-478. http://dx.doi.org/10.1089/mdr/2010.0188.
8. Schwaber MJ, Navon-Venezia S, Masarwa S, Tirosh-Levy S, Adler A, Chmelnitsky I, Carmeli Y, Klement E, Steinman A. 2013. Clonal transmission of a rare methicillin-resistant Staphylococcus aureus genotype between horses and staff at a veterinary teaching hospital. Vet Microbiol 162:907-911. http://dx.doi.org/10.1016/j.vetmic.2012.11.020.
9. Pantosti A. 2012. Methicillin-resistant Staphylococcus aureus associated with animals and its relevance to human health. Front Microbiol 3:127. http://dx.doi.org/10.3389/fmicb.2012.00127.
10. Garcia-Graells C, Antoine J, Larsen J, Catry B, Skov R, Denis O. 2012. Livestock veterinarians at high risk of acquiring methicillin-resistant Staphylococcus aureus ST398. Epidemiol Infect 140:383-389. http://dx.doi/org/10.1017/S0950268811002263.
11. Leonard FC, Markey BK. 2008. Methicillin-resistant Staphylococcus aureus in animals: a review. Vet J 175:27-36. http://dx.doi.org/10.1016/j.tvjl/2006.11.008.
12. Weese JS. 2004. Methicillin-resistant Staphylococcus aureus in horses and horse personnel. Vet Clin North Am Equine Pract 20:601-613. http://dx/doi.org/10.1016/j.cveq.2004.07.009.
13. Clinical and Laboratory Standards Institute. 2011. Performance standards for antimicrobial susceptibility testing; 21st informational supplement. Approved standard MS100-S20. Clinical and Laboratory Standards Institute, Wayne, PA.
14. Strommenger B, Kettlitz C, Weniger T, Harmsen D, Friedrich AW, Witte W. 2006. Assignment of Staphylococcus isolates to groups by spa typing, SmaI macrorestriction analysis, and multilocus sequence typing. J Clin Microbiol 44:2533-2540. http://dx.doi.org/10.1128/JCM.00420-06.
15. Mulvey MR, Chui L, Ismail J, Louie L, Murphy C, Chang N, Alfa M, Canada H, Hospital SB. 2001. Development of a Canadian standardized protocol for subtyping methicillin-resistant Staphylococcus aureus using pulsed-field gel electrophoresis. J Clin Microbiol 39:3481-3485. http://dx/doi.org/10.1128/JCM.39.10.3481-3485.2001.
16. Lina G, Piemont Y, Godail-Gamot F, Bes M, Peter MO, Gauduchon V, Vandenesch F, Etienne J. 1999. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin Infect Dis 29:1128-1132. http://dx.doi.org/10.1086/313461.
17. Zhang K, McClure JA, Elsayed S, Louie T, Conly JM. 2005. Novel multiplex PCR assay for characterization and concomitant subtyping of staphylococcal cassette chromosome mec types I to V in methicillinresistant Staphylococcus aureus. J Clin Microbiol 43:5026. http://dx.doi/org/10.1128/JCM.43.10.5026-5033.2005.
18. van Balen J, Mowery J, Piraino-Sandoval M, Nava-Hoet RC, Kohn C, Hoet AE. 2014. Molecular epidemiology of environmental MRSA at an equine teaching hospital: introduction, circulation, and maintenance. Vet Res 45:31. http://dx.doi.org/10.1186/1297-9716-45-31.
19. Weese JS, van Duijkeren E. 2010. Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine. Vet Microbiol 140:418-429. http://dx.doi.org/10.1016/j.vetmic.2009.01.039.
20. Ridom GmbH.2015. Ridom SpaServer: spa-t002. http://spa.ridom.de/spa/t002.shtml. Accessed 20 March 2015.
21. Adler A, Chmelnitsky I, Shitrit P, Sprecher H, Navon-Venezia S, Embon A, Khabra E, Paitan Y, Keren L, Halperin E, Carmeli Y, Schwaber MJ. 2012. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Israel: dissemination of global clones and unique features. J Clin Microbiol 50:134-137. http://dx.doi.org/10.1128/JCM.05446-11.
22. Van den Eede A, Hermans K, Van den Abeele A, Flore K, Dewulf J, Vanderhaeghen W, Nemeghaire S, Butaye P, Gasthuys F, Haesebrouck F, Martens A. 2013. The nasal vestibulum is the optimal sampling site for MRSA screening in hospitalized horses. Vet J 197:415-419. http://dx.doi/org/10.1016/j.tvjl.2013.01.031.
23. Van den Eede A, Martens A, Lipinska U, Struelens M, Deplano A, Denis O, Haesebrouck F, Gasthuys F, Hermans K. 2009. High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples. Vet Microbiol 133:138-144. http://dx.doi.org/10.1016/j.vetmic.2008.06/021.