Crude Vaccine Effectiveness Is a Misleading Term in Test-negative Studies of Influenza Vaccine Effectiveness

Epidemiology

Volumn 26, Issue 5, 2015, Pages e60-

  Sullivan, Sheena G ^a,b   Cowling, Benjamin J ^c  

^a PETER DOHERTY INSTITUTE FOR INFECTION AND IMMUNITY   (Australia)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE;

CASE CONTROL STUDY; DRUG EFFICACY; FLU LIKE SYNDROME; HUMAN; INFECTION RISK; INFLUENZA; INFLUENZA VACCINATION; LETTER; MEASUREMENT ERROR; OBSERVATIONAL STUDY; PRIORITY JOURNAL; INFLUENZA, HUMAN; ODDS RATIO; OUTCOME ASSESSMENT; PROCEDURES; STATISTICAL BIAS;

BIAS (EPIDEMIOLOGY); HUMANS; INFLUENZA VACCINES; INFLUENZA, HUMAN; OBSERVATIONAL STUDIES AS TOPIC; ODDS RATIO; OUTCOME ASSESSMENT (HEALTH CARE);

EID: 84940047289     PISSN: 10443983     EISSN: 15315487     Source Type: Journal    
DOI: 10.1097/EDE.0000000000000343     Document Type: Letter

References (8)

1. Skowronski D, Chambers C, Sabaiduc S, et al. Interim estimates of 2014/15 vaccine effectiveness against influenza A(H3N2) from Canada s Sentinel Physician Surveillance Network, January 2015. Euro Surveill. 2015;20:21022.
2. Pebody RG, Warburton F, Ellis J, et al. Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid-season results. Euro Surveill. 2015;20:21025.
3. Flannery B, Clippard J, Zimmerman RK, et al.; Centers for Disease Control and Prevention. Early estimates of seasonal influenza vaccine effectiveness-United States, January 2015. MMWR Morb Mortal Wkly Rep. 2015;64:10-15.
4. McNeil SA, Andrew MK, Ye L, et al. Interim estimates of 2014/15 influenza vaccine effectiveness in preventing laboratory-confirmed influenza-related hospitalisation from the Serious Outcomes Surveillance Network of the Canadian Immunization Research Network, January 2015. Euro Surveill. 2015;20:21024.
5. Sullivan SG, Feng S, Cowling BJ. Potential of the test-negative design for measuring influenza vaccine effectiveness: a systematic review. Expert Rev Vaccines. 2014;13: 1571-1591.
6. Greenland S, Rothman KJ, Lash TL. Measures of effect and measures of association. In: Rothman KJ, Greenland S, Lash TL, eds. Modern Epidemiology. 3rd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008;51-70.
7. Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology. 1999;10:37-48.
8. Halloran ME, Longini IM, Struchiner CJ. Design and analysis of vaccine studies. Stat Biol Health. New York, NY: Springer; 2010.